Causes of long-term mortality in patients with head and neck squamous cell carcinomas
Lop Gros, Joan (Institut Hospital del Mar d'Investigacions Mèdiques)
Venegas, María del Prado (Institut d'Investigació Biomèdica Sant Pau)
Pujol-Olmo, Albert (Institut d'Investigació Biomèdica Sant Pau)
Sauter Soler, Blanca (Institut d'Investigació Biomèdica Sant Pau)
Vásquez, Rosselin (Institut d'Investigació Biomèdica Sant Pau)
Casasayas, Maria (Institut d'Investigació Biomèdica Sant Pau)
Quer, Miquel (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
León i Vintró, Xavier (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Purpose: After treatment of a head and neck squamous cell carcinoma (HNSCC), patients with an adequate control of the tumor have a decreased overall survival when compared to age- and gender-matched controls in the general population. The aim of our study was to analyze the causes of long-term mortality in patients with HNSCC. Methods: We carried out a retrospective study of 5122 patients with an index HNSCC treated at our center between 1985 and 2018. We analyzed the survival considering three causes of death: mortality associated with the HNSCC index tumor, mortality associated with a second or successive neoplasm, and mortality associated with a non-cancer cause. Results: After the diagnosis of an HNSCC the most frequent cause of death is the head and neck tumor itself during the first 3. 5 years of follow-up. Thereafter, mortality is more frequently associated with competing causes of death, such as second malignancies and non-cancer causes. Mortality associated with second and successive neoplasms was 2. 3% per year, a percentage that was maintained constant throughout the follow-up. Likewise, mortality attributable to non-cancer causes was 1. 6% per year, which also remained constant. There were differences in the mortality patterns according to the characteristics of the patients. Conclusion: There are differences in the mortality patterns of patients with HNSCC depending on their characteristics. Knowledge of these patterns can help in the design of guidelines to improve the follow-up protocols of this group of patients to optimize the clinical cost-effectiveness.
Ajuts:	Instituto de Salud Carlos III FISPI19/01661
Nota:	Altres ajuts: acords transformatius de la UAB
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Causes of death ; Competing mortality ; Head and neck cancer ; Long-term mortality ; Survival
Publicat a:	European archives of oto-rhino-laryngology, 2021 , ISSN 1434-4726

DOI: 10.1007/s00405-021-07211-8
PMID: 34905065

8 p, 534.6 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats