Evaluation of the role of sex as a prognostic factor in critically ill adults with sepsis : systematic review protocol
Lopez-Alcalde, Jesus (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Antequera, Alba (Institut d'Investigació Biomèdica Sant Pau)
Stallings, Elena (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid))
Muriel, Alfonso (Universidad de Alcalá)
Fernández-Félix, Borja (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Solà, Ivan (Institut d'Investigació Biomèdica Sant Pau)
del Campo, Rosa (Hospital Universitario Ramón y Cajal (Madrid))
Ponce-Alonso, Manuel (Hospital Universitario Ramón y Cajal (Madrid))
Gordo Vidal, Federico (Hospital Universitario del Henares ( Madrid))
Fidalgo, Pilar (Hospital Universitario del Henares ( Madrid))
Halperin, Ana Verónica (Hospital Universitario Ramón y Cajal (Madrid))
Álvarez-Díaz, Noelia (Hospital Universitario Ramón y Cajal (Madrid))
Madrid-Pascual, Olaya (Arztpraxis Kalkbreite)
Urrútia, Gerard (Institut d'Investigació Biomèdica Sant Pau)
Zamora, Javier (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Sepsis is a leading cause of mortality in critically ill patients. Recently, it has been recognised that sex may contribute to a differential risk for developing sepsis and it remains uncertain if the prognosis of sepsis varies between the sexes. The aim of this systematic review is to summarise the available evidence to assess the role of sex as a prognostic factor in patients with sepsis managed in the intensive care unit (ICU). This is a systematic review protocol of prognostic studies of sex in patients with sepsis managed in the ICU. The primary outcomes include all-cause hospital mortality and all-cause hospital mortality during the first 28 days. The secondary outcomes include all-cause hospital mortality during the first 7 days and all-cause mortality at 1 year. We will conduct a search strategy based on the population (sepsis), the prognostic factor (sex), the outcome of interest (mortality) and prognostic study methods. We will search in the following databases up to December 2019: MEDLINE Ovid (from 1976), Embase Elsevier (from 1974), Web of Science and two trial registries. We will impose no language restrictions. Two authors will independently screen titles, abstracts and full-text articles for eligibility of studies, and subsequently extract data. Two authors will independently assess the risk of bias of each study using the Quality in Prognostic Studies (QUIPS) tool. If possible, we will carry out a meta-analysis to provide a pooled prognostic effect estimate for each outcome. We will use the Grading of Recommendations Assessment, Development and Evaluation system to assess the quality of evidence. Ethical approval will not be required. Findings from this review will be reported in a peer-reviewed scientific journal. Additionally, the results will be disseminated at conferences and in the mass media. CRD42019145054.
Ajuts:	Instituto de Salud Carlos III PIE16/00050 Instituto de Salud Carlos III CM18/00141
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adult intensive & critical care ; Infectious diseases ; Epidemiology
Publicat a:	BMJ open, Vol. 10 (may 2020) , ISSN 2044-6055

DOI: 10.1136/bmjopen-2019-035927
PMID: 32381536

5 p, 522.5 KB

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