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| Pàgina inicial > Articles > Articles publicats > A Polymorphism Within the MBP Gene Is Associated With a Higher Relapse Number in Male Patients of Multiple Sclerosis |
(Vall d'Hebron Institut de Recerca (VHIR)) (Hospital Universitari Vall d'Hebron) (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)| Data: | 2020 |
| Resum: | Myelin basic protein (MBP) is thought to be one of the key autoantigens in multiple sclerosis (MS) development. A recent study described the association of the single nucleotide polymorphism (SNP) rs12959006, within the MBP gene, with a higher risk of relapse and worse prognosis. We aim at studying potential associations of this SNP to MS in an independent population. Clinical data of the first 5 years of the disease were collected retrospectively from 291 MS confirmed patients. MBP polymorphism rs12959006 was genotyped in all patients. Associations with EDSS, number of relapses and serology for Herpesvirus 6 (HHV-6) and Epstein Barr (EBV) viruses were studied. Lymphocyte activation measured by CD69 expression was also analyzed according to sex and rs12959006 genotype. The rs12959006 polymorphism contributed significantly to a higher number of relapses at 5 years after onset only in male patients (rs12959006 ∗ TT β = 0. 74 [0. 36-1. 09]; p = 7 × 10 -5). Titers of anti-HHV6 IgG antibodies showed also a mild association with relapses, both in male and female patients (β = 0. 01 [0. 01-0. 02]; p = 3. 7 × 10 -8). Both the genetic variation in MBP and HHV-6 infection aid in predicting a higher number of relapses during the first years of MS. The association described in MBP rs12959006 ∗ T is exclusive to male patients. |
| Ajuts: | Ministerio de Economía y Competitividad PI15/00821 Ministerio de Economía y Competitividad PI16/01259 Ministerio de Economía y Competitividad RD16/0015/0013 Ministerio de Educación, Cultura y Deporte FPU16/00969 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Multiple sclerosis ; SNP ; HHV-6 ; Myelin basic protein ; Relapse ; Sex differences ; Genetic marker |
| Publicat a: | Frontiers in immunology, Vol. 11 (may 2020) , ISSN 1664-3224 |
