Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium : medication matters
Bruin, Willem Benjamin (University of Amsterdam. Department of Psychiatry)
Taylor, Luke (Anatomy and Genetics. Department of Physiology)
Thomas, Rajat M. (Amsterdam University Medical Center (UMC). Department of Psychiatry)
Shock, Jonathan P. (University of Cape Town. Department of mathematics and applied mathematics)
Zhutovsky, Paul (Amsterdam University Medical Center (UMC). Department of Psychiatry)
Abe, Yoshinari (Kyoto Prefectural University of Medicine. Department of Psychiatry, Graduate School of Medical Science)
Alonso, Pino (Universitat de Barcelona. Departament de Ciències Clíniques)
Ameis, Stephanie H. (The Hospital for Sick Children. Centre for Brain and Mental Health)
Anticevic, Alan (Yale University School of Medicine. Department of Psychiatry)
Arnold, Paul D. (University of Calgary. Department of Psychiatry, Cumming School of Medicine)
Assogna, Francesca (IRCCS Santa Lucia Foundation. Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology)
Benedetti, Francesco (San Raffaele Scientific Institute (Milà, Itàlia))
Beucke, Jan C. (Centre for Psychiatric Research and Education, Karolinska Institutet. Department of Clinical Neuroscience)
Boedhoe, Premika (Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience)
Bollettini, Irene (San Raffaele Scientific Institute (Milà, Itàlia))
Bose, Anushree (Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences)
Brem, Silvia (University of Zurich and ETH Zurich, Neuroscience Center Zurich)
Brennan, Brian P. (Harvard Medical School)
Buitelaar, Jan (Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands)
Calvo-Escalona, Rosa (Centro de Investigación Biomédica en Red de Salud Mental)
Cheng, Yuqi (First Affiliated Hospital of Kunming Medical University. Department of Psychiatry)
Cho, Kang Ik K. (Institute of Human Behavioral Medicine, SNU-MRC)
Dallaspezia, Sara (San Raffaele Scientific Institute (Milà, Itàlia))
Denys, Damiaan (Royal Netherlands Academy of Arts and Sciences. Netherlands Institute for Neuroscience)
Ely, Benjamin A. (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica). Department of Psychiatry)
Feusner, Jamie D. (University of California. Department of Psychiatry and Biobehavioral Sciences)
Fitzgerald, Kate D. (University of Michigan. Department of Psychiatry)
Fouche, Jean-Paul (University of Cape Town. Department of Psychiatry and Mental Health)
Fridgeirsson, Egill A. (Amsterdam University Medical Center (UMC). Department of Psychiatry)
Gruner, Patricia (Yale University School of Medicine. Department of Psychiatry)
Gürsel, Deniz A. (Technische Universität München)
Hauser, Tobias U. (University College London. Wellcome Centre for Human Neuroimaging)
Hirano, Yoshiyuki (Chiba University. Research Center for Child Mental Development)
Hoexter, Marcelo Q. (Universidade de Sao Paulo. Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina)
Hu, Hao (Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine)
Huyser, Chaim (Amsterdam Universitair Medische Centra (Amsterdam, Països Baixos). Department of Child and Adolescent Psychiatry)
Ivanov, Iliyan (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica). Department of Psychiatry)
James, Anthony (Oxford University. Department of Psychiatry)
Jaspers-Fayer, Fern (University of British Columbia)
Kathmann, Norbert (Humboldt-Universität zu Berlin. Institut für Psychologie)
Kaufmann, Christian (Humboldt-Universität zu Berlin. Institut für Psychologie)
Koch, Kathrin (Technische Universität München)
Kuno, Masaru (Chiba University. Research Center for Child Mental Development)
Kvale, Gerd (University of Bergen. Department of Clinical Psychology)
Kwon, Jun Soo (Seoul National University College of Natural Sciences. Department of Brain and Cognitive Sciences)
Liu, Yanni (University of Michigan. Department of Psychiatry)
Lochner, Christine (Stellenbosch University. SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry)
Lázaro, Luisa (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Marques, Paulo (Clinical Academic Center-Braga, Braga, Portugal)
Marsh, Rachel (Columbia University. The Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute)
Martínez-Zalacaín, Ignacio (Universitat de Barcelona. Departament de Ciències Clíniques)
Mataix-Cols, David (Karolinska Institutet. Department of Clinical Neuroscience, Centre for Psychiatry Research)
Menchón Magriñá, José Manuel (Universitat de Barcelona. Departament de Ciències Clíniques)
Minuzzi, Luciano (McMaster University. Department of Psychiatry and Behavioural Neurosciences)
Moreira, Pedro S. (Clinical Academic Center-Braga, Braga, Portugal)
Morer, Astrid (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Morgado, Pedro (Clinical Academic Center-Braga, Braga, Portugal)
Nakagawa, Akiko (Chiba University. Research Center for Child Mental Development)
Nakamae, Takashi (Kyoto Prefectural University of Medicine. Department of Psychiatry, Graduate School of Medical Science)
Nakao, Tomohiro (Kyushu University. Department of Neuropsychiatry, Graduate School of Medical Sciences)
Narayanaswamy, Janardhanan C. (Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences)
Nurmi, Erika L. (University of California. Department of Psychiatry and Biobehavioral Sciences)
O'Neill, Joseph (University of California. Division of Child and Adolescent Psychiatry, Jane and Terry Semel Institute For Neurosciences)
Pariente, Jose C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Perriello, Chris (University of Illinois at Urbana-Champaign)
Piacentini, John (University of California. Department of Psychiatry and Biobehavioral Sciences)
Piras, Fabrizio (IRCCS Santa Lucia Foundation. Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology)
Piras, Federica (IRCCS Santa Lucia Foundation. Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology)
Reddy, Y. C. Janardhan (Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences)
Rus-Oswald, Oana G. (University Department of Geriatric Medicine Felix Platter, Basel, Switzerland)
Sakai, Yuki (ATR Brain Information Communication Research Laboratory Group)
Sato, João R. (Universidade Federal do ABC (Brasil))
Schmaal, Lianne (University of Melbourne. Centre for Youth Mental Health)
Shimizu, Eiji (Graduate School of Medicine, Chiba University. Department of Cognitive Behavioral Physiology)
Simpson, H. Blair (New York State Psychiatric Institute. Center for OCD and Related Disorders)
Soreni, Noam (Offord Child Center, McMaster University)
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Spalletta, Gianfranco (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Department of Psychiatry and Behavioral Sciences)
Stern, Emily R. (Nathan Kline Institute for Psychiatric Research)
Stevens, Michael C. (Yale University School of Medicine. Department of Psychiatry)
Stewart, S. Evelyn (British Columbia Mental Health and Addictions Research Institute)
Szeszko, Philip R. (James J. Peters VA Medical Center (Nova York, Estats Units d'Amèrica))
Tolin, David F. (Yale University School of Medicine)
Venkatasubramanian, Ganesan (Obsessive-Compulsive Disorder (OCD) Clinic Department of Psychiatry National Institute of Mental Health and Neurosciences)
Wang, Zhen (Shanghai Key Laboratory of Psychotic Disorders)
Yun, Je-Yeon (Seoul National University College of Medicine. Yeongeon Student Support Center)
van Rooij, Daan (Radboud University Medical Centre. Department of Cognitive Neuroscience)
Thompson, Paul M. (University of Southern California. Imaging Genetics Center, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine)
van den Heuvel, Odile A. (Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience)
Stein, Dan J. (University of Cape Town. SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute)
van Wingen, Guido (Amsterdam University Medical Center (UMC). Department of Psychiatry)

Data:	2020
Resum:	No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the complete sample with different classifiers and cross-validation strategies was poor. When models were validated on data from other sites, model performance did not exceed chance-level. In contrast, fair classification performance was achieved when patients were grouped according to their medication status. These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1247 Instituto de Salud Carlos III PI040829 Instituto de Salud Carlos III FI17/00294 Ministerio de Economía y Competitividad CPII16/00048 Ministerio de Economía y Competitividad PI13/01958 Ministerio de Economía y Competitividad PI16/00889 Ministerio de Economía y Competitividad PI14/00419 Fundació la Marató de TV3 01/2010 Fundació la Marató de TV3 091710
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Neuroscience ; Diagnostic markers
Publicat a:	Translational psychiatry, Vol. 10 (october 2020) , ISSN 2158-3188

DOI: 10.1038/s41398-020-01013-y
PMID: 33033241

12 p, 1.9 MB

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