MicroRNAs in Several Cutaneous Autoimmune Diseases : Psoriasis, Cutaneous Lupus Erythematosus and Atopic Dermatitis
Domingo Bover, Sandra (Hospital Universitari Vall d'Hebron)
Solé, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Moliné, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Ferrer, Berta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Cortés Hernández, Josefina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that regulate the gene expression at a post-transcriptional level and participate in maintaining the correct cell homeostasis and functioning. Different specific profiles have been identified in lesional skin from autoimmune cutaneous diseases, and their deregulation cause aberrant control of biological pathways, contributing to pathogenic conditions. Detailed knowledge of microRNA-affected pathways is of crucial importance for understating their role in skin autoimmune diseases. They may be promising therapeutic targets with novel clinical implications. They are not only present in skin tissue, but they have also been found in other biological fluids, such as serum, plasma and urine from patients, and therefore, they are potential biomarkers for the diagnosis, prognosis and response to treatment. In this review, we discuss the current understanding of the role of described miRNAs in several cutaneous autoimmune diseases: psoriasis (Ps, 33 miRNAs), cutaneous lupus erythematosus (CLE, 2 miRNAs) and atopic dermatitis (AD, 8 miRNAs). We highlight their role as crucial elements implicated in disease pathogenesis and their applicability as biomarkers and as a novel therapeutic approach in the management of skin inflammatory diseases.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Micrornas ; Skin autoimmunity ; Nanoparticles ; Biomarkers ; Pathogenesis ; Psoriasis ; Atopic dermatitis ; Cutaneous lupus erythematosus
Publicat a:	Cells, Vol. 9 (december 2020) , ISSN 2073-4409

DOI: 10.3390/cells9122656
PMID: 33321931

25 p, 7.1 MB

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