Post-Genomic Methodologies and Preclinical Animal Models : Chances for the Translation of Cardioprotection to the Clinic
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
Mendieta, Guiomar (Hospital Clínic i Provincial de Barcelona)
Ben-Aicha Gonzalez, Soumaya (Institut d'Investigació Biomèdica Sant Pau)
Vilahur, Gemma (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Universitat Autònoma de Barcelona

Data:	2019
Resum:	Although many cardioprotective strategies have demonstrated benefits in animal models of myocardial infarction, they have failed to demonstrate cardioprotection in the clinical setting highlighting that new therapeutic target and treatment strategies aimed at reducing infarct size are urgently needed. Completion of the Human Genome Project in 2001 fostered the post-genomic research era with the consequent development of high-throughput "omics" platforms including transcriptomics, proteomics, and metabolomics. Implementation of these holistic approaches within the field of cardioprotection has enlarged our understanding of ischemia/reperfusion injury with each approach capturing a different angle of the global picture of the disease. It has also contributed to identify potential prognostic/diagnostic biomarkers and discover novel molecular therapeutic targets. In this latter regard, "omic" data analysis in the setting of ischemic conditioning has allowed depicting potential therapeutic candidates, including non-coding RNAs and molecular chaperones, amenable to pharmacological development. Such discoveries must be tested and validated in a relevant and reliable myocardial infarction animal model before moving towards the clinical setting. Moreover, efforts should also focus on integrating all "omic" datasets rather than working exclusively on a single "omic" approach. In the following manuscript, we will discuss the power of implementing "omic" approaches in preclinical animal models to identify novel molecular targets for cardioprotection of interest for drug development.
Ajuts:	Ministerio de Ciencia e Innovación PNS/2015-71653-R Ministerio de Ciencia e Innovación PNS/SAF2016-76819-R Instituto de Salud Carlos III CN16/11/00411 Instituto de Salud Carlos III RD16/0011/018 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1480
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	Post-genomics ; -omics ; Targets ; Ncrna ; Chaperones ; Cardioprotection
Publicat a:	International journal of molecular sciences, Vol. 20 (january 2019) , ISSN 1422-0067

DOI: 10.3390/ijms20030514
PMID: 30691061

13 p, 1.1 MB

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