Use of acute phase proteins for the clinical assessment and management of canine leishmaniosis : general recommendations
Cerón, José Joaquín (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Pardo-Marín, Luis (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Caldin, Marco (San Marco Veterinary Clinic)
Furlanello, Tommaso (San Marco Veterinary Clinic)
Solano Gallego, Laia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Tecles, Fernando (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Bernal, L. (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Baneth, Gad (Hebrew University. Koret School of Veterinary Medicine)
Martínez-Subiela, Silvia (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)

Data:	2018
Resum:	Dogs with canine leishmaniosis (CanL) due to Leishmania infantum can show a wide spectrum of clinical and clinicopathological findings at the time of diagnosis. The aim of this paper is to describe the possible application of acute phase proteins (APPs) for the characterization and management of this disease, based on previously published information on the utility of APPs in CanL and the experience of the authors in using APPs as analytes in the profiling of canine diseases. Dogs diagnosed with L. infantum infection by serology, polymerase chain reaction, cytological or histopathological identification, can be divided into three groups based on their clinical condition at physical examination and their APPs concentrations: Group 1: dogs with no clinical signs on physical examination and APPs in reference range; Group 2: dogs with changes in APPs but no clinical signs on physical examination; Group 3: dogs with clinical signs and changes in APPs. This report describes the main characteristics of each group as well as its association with the clinical classification schemes of CanL. APPs concentration can be a useful clinical tool to characterize and manage CanL.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Canine leishmaniosis ; Acute phase proteins ; Staging
Publicat a:	BMC veterinary research, Vol. 14 (june 2018) , ISSN 1746-6148

DOI: 10.1186/s12917-018-1524-y
PMID: 29925385

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