Web of Science: 45 cites, Scopus: 45 cites, Google Scholar: cites,
The Lung in Primary Immunodeficiencies : New Concepts in Infection and Inflammation
Baumann, Ulrich (Hannover Medical School)
Routes, John M. (Medical College of Wisconsin)
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Jolles, Stephen (University Hospital of Wales)
Universitat Autònoma de Barcelona

Data: 2018
Resum: Immunoglobulin replacement therapy (IGRT) has contributed critically to the management of primary antibody deficiencies (PAD) and the decrease in pneumonia rate. However, despite adequate IGRT and improved prognosis, patients with PAD continue to experience recurrent respiratory tract infections, leading to bronchiectasis and continuing decline in lung function with a severe impact on their quality of life. Moreover, non-infectious inflammatory and interstitial lung complications, such as granulomatous-lymphocytic interstitial lung disease, contribute substantially to the overall morbidity of PAD. These conditions develop much more often than appreciated and represent a major therapeutic challenge. Therefore, a regular assessment of the structural and functional condition of the lung and the upper airways with appropriate treatment is required to minimize the deterioration of lung function. This work summarizes the knowledge on lung complications in PAD and discusses the currently available diagnostic tools and treatment options.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Primary immunodeficiency ; Lung complications ; Immunoglobulin ; Comorbidity ; Bronchiectasis ; Granulomatous-lymphocytic interstitial lung disease ; Pulmonary functional tests ; Lung computed tomographic scan
Publicat a: Frontiers in immunology, Vol. 9 (august 2018) , ISSN 1664-3224

DOI: 10.3389/fimmu.2018.01837
PMID: 30147696


16 p, 2.6 MB

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