-Dopa/carbidopa intestinal gel and subthalamic nucleus stimulation : Effects on cognition and behavior
Valldeoriola, Francesc (Hospital Clínic i Provincial de Barcelona)
Santacruz, Pilar (Hospital Clínic i Provincial de Barcelona)
Ríos, José (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Compta, Yaroslau (Universitat de Barcelona)
Rumià, Jordi (Hospital Clínic i Provincial de Barcelona)
Muñoz, José Esteban (Hospital Clínic i Provincial de Barcelona)
Martí, María José (Hospital Clínic i Provincial de Barcelona)
Tolosa, Eduardo (Hospital Clínic i Provincial de Barcelona)

Data:	2017
Resum:	In Parkinson's disease (PD), effects on behavior and cognition of levodopa/carbidopa intestinal gel (LCIG) and subthalamic stimulation (STN-DBS) and their practical consequences remain controversial. This study was designed to analyze the possible effects of these therapies on cognition and behavior after 1 year follow-up. This was an open-label, nonrandomized prospective study for pre- and postintervention analyses. Twenty-four patients were considered eligible to be candidates for complex therapies such as STN-DBS or LCIG; 23 patients treated with standard medication were included as controls. Several cognitive, behavioral, and motor scales were administered before and at 6 and 12 months after the intervention. Patients treated with LCIG experienced significant improvement in specific neuropsychological functions when compared with patients receiving STN-DBS and conventional medical treatment after 1 year from the onset of the intervention. In this study, no significant cognitive or behavioral changes occurred in patients treated with subthalamic stimulation when compared to patients receiving conventional medical treatment at 1 year follow-up. Patients treated with LCIG may significantly improve some specific neuropsychological functions when compared with patients receiving STN-DBS and with patients receiving conventional medical treatment after 1 year from the intervention; there are not significant cognitive or behavioral changes in patients treated with STN-DBS when compared to PD patients receiving conventional medical treatment after 1 year from the intervention. The outcomes showed in the study can help to the selection of the appropriate candidates for STN-DBS and LCIG.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Behavior ; Cognition ; Intestinal -dopa ; Parkinson ; Subthalamic stimulation
Publicat a:	Brain and behavior, Vol. 7 (october 2017) , ISSN 2162-3279

DOI: 10.1002/brb3.848
PMID: 29201549

7 p, 414.8 KB

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