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| Pàgina inicial > Articles > Articles publicats > Opposite Cannabis-Cognition Associations in Psychotic Patients Depending on Family History |
| Data: | 2016 |
| Resum: | The objective of this study is to investigate cognitive performance in a first-episode psychosis sample, when stratifying the interaction by cannabis use and familial or non-familial psychosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family history of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no family history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis. |
| Ajuts: | Instituto de Salud Carlos III PI080208 Instituto de Salud Carlos III PI10/01430 Instituto de Salud Carlos III PI10/01746 Instituto de Salud Carlos III PI11/01977 Instituto de Salud Carlos III PI11/02708 Instituto de Salud Carlos III 2011/1064 Instituto de Salud Carlos III PI12/02077 Instituto de Salud Carlos III PI13/02252 Instituto de Salud Carlos III PI13/00451 Instituto de Salud Carlos III PI14/01900 Instituto de Salud Carlos III PI11/02831 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-441 Agència de Gestió d'Ajuts Universitaris i de Recerca 2015/FI_B2-00100 European Commission 241909 European Commission 242114 European Commission 603196 European Commission 602478 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Publicat a: | PloS one, Vol. 11 (august 2016) , ISSN 1932-6203 |
16 p, 1.0 MB |