Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
Lawrenson, Kate (University of Southern California Norris Comprehensive Cancer Center)
Kar, Siddhartha (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge)
McCue, Karen (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Kuchenbaeker, Karoline (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Michailidou, Kyriaki (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Tyrer, Jonathan (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Beesley, Jonathan (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Ramus, Susan J. (University of Southern California Norris Comprehensive Cancer Center)
Li, Qiyuan (Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute)
Delgado, Melissa K. (University of Southern California Norris Comprehensive Cancer Center)
Lee, Janet M. (University of Southern California Norris Comprehensive Cancer Center)
Aittomäki, Kristiina (Helsinki University Hospital (Finlàndia))
Andrulis, Irene L. (Department of Molecular Genetics, University of Toronto)
Anton-Culver, Hoda (Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine)
Arndt, Volker (German Cancer Research Center (DKFZ))
Arun, Banu K. (University of Texas MD Anderson Cancer Center)
Arver, Brita (Karolinska University Hospital and Karolinska Institutet (Suècia))
Bandera, Elisa V. (Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey)
Barile, Monica (Istituto Europeo di Oncologia (Milà, Itàlia))
Barkardottir, Rosa B. (Department of Pathology, Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland)
Barrowdale, Daniel (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Beckmann, Matthias W. (University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN)
Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Berchuck, Andrew (Department of Obstetrics and Gynecology, Duke University Medical Center)
Bisogna, Maria (Memorial Sloan Kettering Cancer Center)
Bjorge, Line (Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen)
Blomqvist, Carl (Helsinki University Hospital (Finlàndia))
Blot, William (International Epidemiology Institute)
Bogdanova, Natalia (Hannover Medical School)
Bojesen, Anders (Vejle Hospital (Vejle, Dinamarca))
Bojesen, Stig E. (Copenhagen University Hospital)
Bolla, Manjeet K. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Bonanni, Bernardo (Istituto Europeo di Oncologia (Milà, Itàlia))
Børresen-Dale, Anne-Lise (K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo)
Brauch, Hiltrud (German Cancer Research Center (DKFZ))
Brennan, Paul (International Agency for Research on Cancer)
Brenner, Hermann (German Cancer Research Center (DKFZ))
Bruinsma, Fiona (Cancer Epidemiology Centre (Melbourne, Austràlia))
Brunet, Joan (Institut d'Investigació Biomèdica de Girona)
Buhari, Shaik Ahmad (Department of Surgery, National University Health System)
Burwinkel, Barbara (Department of Obstetrics and Gynecology, University of Heidelberg)
Butzow, Ralf (Department of Pathology, Helsinki University Central Hospital)
Buys, Saundra (Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine)
Cai, Qiuyin (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)
Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Campbell, Ian (Cancer Genetics Laboratory, Peter MacCallum Cancer Centre)
Canniotto, Rikki (Cancer Pathology & Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute)
Chang-Claude, Jenny (University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf)
Chiquette, Jocelyne (Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec)
Choi, Ji-Yeob (Department of Biomedical Sciences, Seoul National University College of Medicine)
Claes, Kathleen (Center for Medical Genetics, Ghent University)
Cook, Linda S. (Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico)
Cox, Angela (Sheffield Cancer Research, Department of Oncology, University of Sheffield)
Cramer, Daniel W. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Cross, Simon S. (Academic Unit of Pathology, Department of Neuroscience, University of Sheffield)
Cybulski, Cezary (Pomeranian Medical University, Department of Genetics and Pathology)
Czene, Kamila (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics)
Daly, Mary B. (Fox Chase Cancer Center (Philadelphia, Estats Units d'Amèrica))
Damiola, Francesca (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon)
Dansonka-Mieszkowska, Agnieszka (Maria Sklodowska Curie Memorial Cancer Center)
Darabi, Hatef (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics)
Dennis, Joe (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Devilee, Peter (Leiden University Medical Center)
Diez, Orland (Vall d'Hebron Institut d'Oncologia)
Doherty, Jennifer A. (Geisel School of Medicine at Dartmouth (Hanover, Estats Units d'Amèrica))
Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania)
Dorfling, Cecilia M. (Department of Genetics, University of Pretoria)
Dörk, Thilo (Hannover Medical School)
Dumont, Martine (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University)
Ehrencrona, Hans (Department of Clinical Genetics, Lund University Hospital)
Ejlertsen, Bent (Copenhagen University Hospital Rigshospitalet)
Ellis, Steve (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig)
Lee, Eunjung (University of Southern California Norris Comprehensive Cancer Center)
Evans, Gareth (Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust)
Fasching, Peter A. (University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology)
Feliubadalo, Lidia (Institut d'Investigació Biomèdica de Bellvitge)
Figueroa, Jonine (Division of Cancer Epidemiology and Genetics, National Cancer Institute)
Flesch-Janys, Dieter (Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf)
Fletcher, Olivia (Division of Breast Cancer Research, The Institute of Cancer Research)
Flyger, Henrik (Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital)
Foretova, Lenka (Masaryk Memorial Cancer Institute and Medical Faculty MU)
Fostira, Florentia (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis)
Foulkes, William (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal)
Fridley, Brooke L. (Biostatistics and Informatics Shared Resource, University of Kansas Medical Center)
Friedman, Eitan (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center)
Frost, Debra (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Gambino, Gaetana (University Hospital of Pisa (Pisa, Itàlia))
Ganz, Patricia A. (University of California Los Angeles Schools of Medicine and Public Health)
Garber, Judy (Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute)
García-Closas, Montserrat (Division of Genetics and Epidemiology, The Institute of Cancer Research)
Gentry-Maharaj, Aleksandra (Women's Cancer, UCL EGA Institute for Women's Health)
Ghoussaini, Maya (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Giles, Graham G. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)
Glasspool, Rosalind (Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre)
Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, University of Kansas Medical Center)
Goldberg, Mark S. (Department of Medicine, McGill University)
Goldgar, David E. (Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine)
González-Neira, Anna (Centro Nacional de Investigaciones Oncológicas)
Goode, Ellen L. (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Goodman, Marc T. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica))
Greene, Mark H. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health)
Gronwald, Jacek (Department of Genetics and Pathology, Pomeranian Medical University)
Guénel, Pascal (University Paris-Sud)
Haiman, Christopher A. (University of Southern California Norris Comprehensive Cancer Center)
Hall, Per (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics)
Hallberg, Emily (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Hamann, Ute (German Cancer Research Center (DKFZ))
Hansen, Thomas V. O. (Copenhagen University Hospital Rigshospitalet)
Harrington, Patricia A. (Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory)
Hartman, Mikael (Saw Swee Hock School of Public Health, National University of Singapore)
Hassan, Norhashimah (Cancer Research Initiatives Foundation, Subang Jaya)
Healey, Sue (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Heitz, Florian (Helios Dr. Horst Schmidt Hospital Wiesbaden)
Herzog, Josef (City of Hope Clinical Cancer Genetics Community Research Network (Duarte, Estats Units d'Amèrica))
Høgdall, Estrid (Danish Cancer Society Research Center)
Høgdall, Claus K. (Copenhagen University Hospital Rigshospitalet)
Hogervorst, Frans B. L. (The Netherlands Cancer Institute (Amsterdam, Països Baixos))
Hollestelle, Antoinette (Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute)
Hopper, John L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)
Hulick, Peter J. (Center for Medical Genetics, NorthShore University Health System)
Huzarski, Tomasz (Department of Genetics and Pathology, Pomeranian Medical University)
Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology)
Isaacs, Claudine (Lombardi Comprehensive Cancer Center, Georgetown University)
Ito, Hidemi (Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute)
Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University)
Janavicius, Ramunas (State Research Institute Centre for Innovative Medicine)
Jensen, Allan (Copenhagen University Hospital Rigshospitalet)
John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California)
Johnson, Nichola (Division of Breast Cancer Research, The Institute of Cancer Research)
Kabisch, Maria (German Cancer Research Center (DKFZ))
Kang, Daehee (Department of Preventive Medicine, Seoul National University College of Medicine)
Kapuscinski, Miroslav (Centre for Epidemiology and Biostatistics, University of Melbourne)
Karlan, Beth Y. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica))
Khan, Sofia (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital)
Kiemeney, Lambertus A. (Radboud University Medical Centre, Radboud Institute for Health Sciences)
Kjaer, Susanne Kruger (Copenhagen University Hospital Rigshospitalet)
Knight, Julia A. (Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto)
Konstantopoulou, Irene (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis)
Kosma, Veli-Matti (Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland)
Kristensen, Vessela (Oslo University Hospital (Oslo, Noruega))
Kupryjanczyk, Jolanta (Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology)
Kwong, Ava (Department of Surgery, The University of Hong Kong)
De la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Laitman, Yael (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center)
Lambrechts, Diether (Laboratory for Translational Genetics, Department of Oncology, University of Leuven)
Le, Nhu (University of Southern California Norris Comprehensive Cancer Center)
De Leeneer, Kim (Center for Medical Genetics, Ghent University)
Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica))
Levine, Douglas A. (Memorial Sloan Kettering Cancer Center)
Li, Jingmei (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics)
Lindblom, Annika (Karolinska Institutet (Estocolm, Suècia). Department of Molecular Medicine and Surgery)
Long, Jirong (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)
Lophatananon, Artitaya (Division of Health Sciences, Warwick Medical School, Warwick University)
Loud, Jennifer T. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health)
Lu, Karen (Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center)
Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University)
Mannermaa, Arto (Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland)
Manoukian, Siranoush (Fondazione IRCCS Istituto Nazionale dei Tumori)
Le Marchand, Loic (University of Hawaii Cancer Center)
Margolin, Sara (Department of Oncology - Pathology, Karolinska Institutet)
Marme, Frederik (National Center for Tumour Diseases, University of Heidelberg)
Massuger, Leon F. A. G. (Radboud University Medical Centre. Department of Gynaecology)
Matsuo, Keitaro (Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences)
Mazoyer, Sylvie (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon)
McGuffog, Lesley (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge)
McLean, Catriona (Anatomical Pathology, The Alfred Hospital)
McNeish, Iain (Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research)
Meindl, Alfons (Technische Universität München)
Menon, Usha (Women's Cancer, UCL EGA Institute for Women's Health)
Mensenkamp, Arjen R. (Department of Human Genetics, Radboud University Medical Centre)
Milne, Roger L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)
Montagna, Marco (Immunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS)
Moysich, Kirsten B. (Department of Cancer Prevention and Control, Roswell Park Cancer Institute)
Muir, Kenneth (Institute of Population Health, University of Manchester)
Mulligan, Anna Marie (Department of Laboratory Medicine and Pathobiology, University of Toronto)
Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania)
Ness, Roberta B. (The University of Texas School of Public Health)
Neuhausen, Susan L. (Department of Population Sciences, Beckman Research Institute of City of Hope)
Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital)
Nord, Silje (K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo)
Nussbaum, Robert L. (Department of Medicine and Genetics, University of California)
Odunsi, Kunle (Department of Gynecological Oncology, Roswell Park Cancer Institute)
Offit, Kenneth (Memorial Sloan Kettering Cancer Center)
Olah, Edith (Department of Molecular Genetics, National Institute of Oncology)
Olopade, Olufunmilayo I. (Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center)
Olson, Janet E. (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Olswold, Curtis (Mayo Clinic (Rochester, Estats Units d'Amèrica))
O'Malley, David (The Ohio State University and the James Cancer Center)
Orlow, Irene (Memorial Sloan Kettering Cancer Center. Department of Epidemiology and Biostatistics)
Orr, Nick (Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research)
Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Park, Sue Kyung (Department of Surgery, Seoul National University College of Medicine)
Pearce, Celeste L. (University of Southern California Norris Comprehensive Cancer Center)
Pejovic, Tanja (Knight Cancer Institute, Oregon Health and Science University)
Peterlongo, Paolo (IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology)
Pfeiler, Georg (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna)
Phelan, Catherine M. (Moffitt Cancer Center (Tampa, Estats Units d'Amèrica))
Poole, Elizabeth M. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica))
Pylkäs, Katri (Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu)
Radice, Paolo (Istituto Nazionale dei Tumori (Milà, Itàlia))
Rantala, Johanna (Karolinska University Hospital and Karolinska Institutet (Suècia))
Rashid, Muhammad Usman (Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC))
Rennert, Gad (Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine)
Rhenius, Valerie (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Rhiem, Kerstin (University Hospital of Cologne (Colònia, Alemanya). Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO))
Risch, Harvey A. (Yale School of Public Health)
Rodriguez, Gus (Division of Gynecologic Oncology, NorthShore University HealthSystem)
Rossing, Mary Anne (Department of Epidemiology, University of Washington)
Rudolph, Anja (German Cancer Research Center (DKFZ))
Salvesen, Helga B. (Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen)
Sangrajrang, Suleeporn (National Cancer Institute)
Sawyer, Elinor J. (King's College London)
Schildkraut, Joellen M. (Cancer Control and Population Sciences, Duke Cancer Institute)
Schmidt, Marjanka K. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital)
Schmutzler, Rita K. (Uniklinik Köln (Colònia, Alemanya))
Sellers, Thomas A. (Moffitt Cancer Center (Tampa, Estats Units d'Amèrica))
Seynaeve, Caroline (Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute)
Shah, Mitul (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Shen, Chen-Yang (School of Public Health, China Medical University)
Shu, Xiao-Ou (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)
Sieh, Weiva (Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine)
Singer, Christian F. (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna)
Sinilnikova, Olga M. (INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon)
Slager, Susan (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Song, Honglin (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Soucy, Penny (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University)
Southey, Melissa C. (Department of Pathology, University of Melbourne)
Stenmark-Askmalm, Marie (Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University)
Stoppa-Lyonnet, Dominique (Université Paris Descartes)
Sutter, Christian (Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg)
Swerdlow, Anthony (Division of Genetics and Epidemiology, The Institute of Cancer Research)
Tchatchou, Sandrine (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital)
Teixeira, Manuel R. (Biomedical Sciences Institute (ICBAS), Porto University)
Teo, Soo (Cancer Research Initiatives Foundation, Subang Jaya)
Terry, Kathryn L. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Terry, Mary Beth (Department of Epidemiology, Mailman School of Public Health, Columbia University)
Thomassen, Mads (Odense University Hospital (Dinamarca))
Tibiletti, Maria Grazia (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria)
Tihomirova, Laima (Latvian Biomedical Research and Study Centre)
Tognazzo, Silvia (Istituto Oncologico Veneto)
Toland, Amanda Ewart (Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University)
Tomlinson, Ian (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit))
Torres, Diana (Institute of Human Genetics, Pontificia Universidad Javeriana, Cra. 7 #40-62)
Truong, Thérèse (University Paris-Sud)
Tseng, Chiu-chen (University of Southern California Norris Comprehensive Cancer Center)
Tung, Nadine (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Tworoger, Shelley S. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica))
Vachon, Celine (Mayo Clinic (Rochester, Estats Units d'Amèrica))
van den Ouweland, Ans M. W. (Department of Clinical Genetics, Erasmus University Medical Center)
van Doorn, Helena C. (Department of Gynecology, Family Cancer Clinic, Erasmus MC Cancer Institute)
van Rensburg, Elizabeth J. (Department of Genetics, University of Pretoria)
Van't Veer, Laura J. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital)
Vanderstichele, Adriaan (University Hospitals Leuven (Bèlgica))
Vergote, Ignace (University Hospitals Leuven (Bèlgica))
Vijai, Joseph (Memorial Sloan Kettering Cancer Center)
Wang, Qin (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Wang-Gohrke, Shan (University Hospital Ulm, 89069 Ulm)
Weitzel, Jeffrey N. (City of Hope Clinical Cancer Genetics Community Research Network (Duarte, Estats Units d'Amèrica))
Wentzensen, Nicolas (Division of Cancer Epidemiology and Genetics, National Cancer Institute)
Whittemore, Alice S. (Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine)
Wildiers, Hans (University Hospitals Leuven (Bèlgica))
Winqvist, Robert (Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu)
Wu, Anna H. (University of Southern California Norris Comprehensive Cancer Center)
Yannoukakos, Drakoulis (Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos')
Yoon, Sook-Yee (University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya)
Yu, Jyh-Cherng (Department of Surgery, Tri-Service General Hospital, National Defense Medical Center)
Zheng, Wei (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)
Zheng, Ying (Shanghai Center for Disease Control and Prevention)
Khanna, Kum Kum (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Simard, Jacques (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University)
Monteiro, Alvaro N. (Cancer Epidemiology Program, Division of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute)
French, Juliet D. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Couch, Fergus J. (Mayo Clinic (Rochester, Estats Units d'Amèrica). Department of Laboratory Medicine and Pathology)
Freedman, Matthew L. (Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute)
Easton, Douglas F. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Dunning, Alison M. (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Pharoah, Paul D. (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Edwards, Stacey L. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Chenevix-Trench, Georgia (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Antoniou, Antonis C. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge)
Gayther, Simon A. (University of Southern California Norris Comprehensive Cancer Center)
Universitat Autònoma de Barcelona

Data:	2016
Resum:	A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P =9. 2 × 10 -20), ER-negative BC (P =1. 1 × 10 -13), BRCA1 -associated BC (P =7. 7 × 10 -16) and triple negative BC (P -diff=2 × 10 -5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P =2 × 10 -3) and ABHD8 (P <2 × 10 -3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3'-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk. A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Nature communications, Vol. 7 (09 2016) , ISSN 2041-1723

DOI: 10.1038/ncomms12675
PMID: 27601076

22 p, 1.6 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats