Neuroticism Associated with Cocaine-Induced Psychosis in Cocaine-Dependent Patients : A Cross-Sectional Observational Study
Roncero, Carlos (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Daigre, Constanza (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Barral, Carmen (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Ros-Cucurull, Elena (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Grau-López, Lara (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Rodríguez-Cintas, Laia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Tarifa, Nuria (Hospital Universitari Vall d'Hebron)
Casas Brugué, Miquel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Valero, Sergi (Hospital Universitari Vall d'Hebron)

Data:	2014
Resum:	Cocaine consumption can induce transient psychotic symptoms, which has been correlated with more severe addiction and aggressive behavior. However, little is known about the nature of the relationship between personality traits and psychotic symptoms in cocaine-dependent patients. This study examined the relationship between neuroticism and cocaine-induced psychosis. A total of 231 cocaine-dependent patients seeking treatment were recruited to the study. Personality was evaluated by the Zuckerman-Kuhlman Personality Questionnaire. Cocaine-induced psychosis questionnaire, SCID-I, and SCID-II were used to evaluate comorbidity and clinical characteristics. Data analysis was performed in three steps: descriptive, bivariate, and multivariate analyses. Cocaine-induced psychosis was reported in 65. 4% of the patients and some personality disorder in 46. 8%. Two personality dimensions (Neuroticism-Anxiety and Aggression-Hostility) presented a significant effect on the risk of experiencing psychotic symptoms (t (229) = 2. 69, p = 0. 008; t (229) = 2. 06, p = 0. 004), and patients with psychotic symptoms showed higher scores in both variables. On the multivariate analysis, only Neuroticism remained as a significant personality factor independently associated with psychotic symptoms (Wald = 7. 44, p <0. 05, OR = 1. 08, CI 95% 1. 02-1. 16) after controlling for age, gender and number of consumption substances. An association between high neuroticism scores and presence of psychotic symptoms induced by cocaine has been found, independently of other consumption variables. Personality dimensions should be evaluated in cocaine-dependent patients in order to detect high scores of neuroticism and warn patients about the risk of developing cocaine-induced psychotic symptoms.
Ajuts:	Instituto de Salud Carlos III PI13/1911
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 9 (september 2014) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0106111
PMID: 25254365

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