Diabetes Is the Main Factor Accounting for Hypomagnesemia in Obese Subjects
Lecube, Albert (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Baena-Fustegueras, Juan Antonio (Hospital Universitari Vall d'Hebron)
Fort, José Manuel (Hospital Universitari Vall d'Hebron)
Pelegrí-Sisó, Dolors (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Date:	2012
Abstract:	Type 2 diabetes (T2DM) and obesity are associated with magnesium deficiency. We aimed to determine whether the presence of type 2 diabetes and the degree of metabolic control are related to low serum magnesium levels in obese individuals. A) Case-control study: 200 obese subjects [50 with T2DM (cases) and 150 without diabetes (controls)] prospectively recruited. B) Interventional study: the effect of bariatric surgery on serum magnesium levels was examined in a subset of 120 obese subjects (40 with type 2 diabetes and 80 without diabetes). Type 2 diabetic patients showed lower serum magnesium levels [0. 75±0. 07 vs. 0. 81±0. 06 mmol/L; mean difference −0. 06 (95% CI −0. 09 to −0. 04); p<0. 001] than non-diabetic patients. Forty-eight percent of diabetic subjects, but only 15% of non-diabetic subjects showed a serum magnesium concentration lower than 0. 75 mmol/L. Significant negative correlations between magnesium and fasting plasma glucose, HbA1c, HOMA-IR, and BMI were detected. Multiple linear regression analysis showed that fasting plasma glucose and HbA1c independently predicted serum magnesium. After bariatric surgery serum magnesium increased only in those patients in whom diabetes was resolved, but remain unchanged in those who not, without difference in loss weight between groups. Changes in serum magnesium negatively correlated with changes in fasting plasma glucose and HbA1c. Absolute changes in HbA1c independently predicted magnesium changes in the multiple linear regression analysis. Our results provide evidence that the presence of diabetes and the degree of metabolic control are essential in accounting for the lower levels of magnesium that exist in obese subjects.
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 7 (january 2012) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0030599
PMID: 22291997

7 p, 243.4 KB

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