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Pàgina inicial > Articles > Articles publicats > Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children |
Data: | 2022 |
Resum: | Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays' (IGRAs) performance and cytokine immune responses. A total of 616 children from contact-tracing studies were included and classified regarding their smoking habits [unexposed, SHS, or smokers]. Risk factors for positive IGRAs, LTBI, and active TB were defined. GM-CSF, IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-22, IL-17, TNF-α, IL-1RA and IP-10 cytokines were detected in a subgroup of patients. Being SHS exposed was associated with a positive IGRA [aOR (95% CI): 8. 7 (5. 9-12. 8)] and was a main factor related with LTBI [aOR (95% CI): 7. 57 (4. 79-11. 94)] and active TB [aOR (95% CI): 3. 40 (1. 45-7. 98)]. Moreover, IGRAs' sensitivity was reduced in active TB patients exposed to tobacco. IL-22, GM-CSF, IL-5, TNF-α, IP-10, and IL-13 were less secreted in LTBI children exposed to SHS. In conclusion, SHS is associated with LTBI and active TB in children. In addition, false-negative IGRAs obtained on active TB patients exposed to SHS, together with the decrease of specific cytokines released, suggest that tobacco may alter the immune response. |
Ajuts: | Ministerio de Economía y Competitividad PI13/01546 Ministerio de Economía y Competitividad PI16/01912 Instituto de Salud Carlos III PI18/00411 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Mycobacterium tuberculosis ; Cigarette smoking ; Passive smoking ; Child ; Immunology |
Publicat a: | Journal of clinical medicine, Vol. 11 (april 2022) , ISSN 2077-0383 |
12 p, 995.8 KB |