Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
Jesson, Julie (Université Paul Sabatier Toulouse 3)
Crichton, Siobhan (University College London. MRC Clinical Trials Unit)
Quartagno, Matteo (University College London. MRC Clinical Trials Unit)
Yotebieng, Marcel (Albert Einstein College of Medicine (Nova York, Estats Units d'Amèrica))
Abrams, Elaine J. (Columbia University. Mailman School of Public Health. ICAP at Columbia University)
Chokephaibulkit, Kulkanya (Mahidol University. Faculty of Medicine Siriraj Hospital. Siriraj Institute of Clinical Research)
Le Coeur, Sophie (Chiang Mai University. Faculty of Associated Medical Sciences. UMI-174/PHPT. Institut de Recherche pour le Developpement (IRD))
Aké-Assi, Marie-Hélène (University Hospital Yopougon)
Patel, Kunjal (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica))
Pinto, Jorge (Federal University of Minas Gerais. School of Medicine)
Paul, Mary (Texas Children's Hospital-USA. Baylor International Pediatric AIDS Initiative)
Vreeman, Rachel (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Davies, Mary-Ann (University of Cape Town. Faculty of Health Sciences. School of Public Health and Family Medicine)
Ben-Farhat, Jihane (Médecins Sans Frontières. Epicentre)
Van Dyke, Russell (Tulane University Health Sciences Center)
Judd, Ali (University College London. MRC Clinical Trials Unit)
Mofenson, Lynne (Elizabeth Glaser Pediatric AIDS Foundation)
Vicari, Marissa (International AIDS Society)
Seage, George (University Hospital Yopougon)
Bekker, Linda-Gail (University of Cape Town. Desmond Tutu HIV Centre)
Essajee, Shaffiq (UNICEF)
Gibb, Diana (University College London. MRC Clinical Trials Unit)
Penazzato, Martina (World Health Organization)
Collins, Intira Jeannie (University College London. MRC Clinical Trials Unit)
Wools-Kaloustian, Kara (Indiana University School of Medicine)
Slogrove, Amy (Stellenbosch University. Faculty of Medicine & Health Sciences)
Powis, Kate (University Hospital Yopougon)
Williams, Paige (University Hospital Yopougon)
Matshaba, Mogomotsi (Baylor College of Medicine Children's Foundation)
Thahane, Lineo (Baylor College of Medicine Children's Foundation)
Nyasulu, Phoebe (Baylor College of Medicine Children's Foundation)
Lukhele, Bhekumusa (Baylor College of Medicine Children's Foundation)
Mwita, Lumumba (Baylor College of Medicine Children's Foundation)
Kekitiinwa-Rukyalekere, Adeodata (Baylor College of Medicine Children's Foundation)
Wanless, Sebastian (Federal University of Minas Gerais. School of Medicine)
Goetghebuer, Tessa (Hospital St Pierre)
Thorne, Claire (University College London. UCL Great Ormond Street Institute of Child Health)
Warszawski, Josiane (Centre de recherche en Epidémiologie et Santé des Populations. Inserm U1018)
Galli, Luisa (Università degli Studi di Firenze)
van Rossum, Annemarie M. C. (Erasmus MC University Medical Center Rotterdam-Sophia Children's Hospital)
Giaquinto, Carlo (Padova University/PENTA Foundation)
Marczynska, Magdalena (Hospital of Infectious Diseases in Warsaw. Medical University of Warsaw)
Marques, Laura (Centro Hospitalar do Porto)
Prata, Filipa (Hospital de Santa Maria)
Ene, Luminita (Victor Babes Hospital)
Okhonskaya, Lyuba (Republican Hospital of Infectious Diseases)
Navarro, Marisa (Hospital General Universitario Gregorio Marañón)
Frick, Antoinette (Hospital Universitari Vall d'Hebron)
Naver, Lars (Hospital Universitari Vall d'Hebron)
Kahlert, Christian (Children's Hospital of Eastern Switzerland)
Volokha, Alla (Shupyk National Medical Academy of Postgraduate Education)
Chappell, Elizabeth (University College London. MRC Clinical Trials Unit)
Pape, Jean William (GHESKIO Center)
Rouzier, Vanessa (GHESKIO Center)
Marcelin, Adias (GHESKIO Center)
Succi, Regina (Universidade Federal de São Paulo)
Sohn, Annette H. (TREAT Asia/amfAR)
Kariminia, Azar (University of New South Wales. Kirby Institute)
Edmonds, Andrew (University of North Carolina at Chapel Hill. Gillings School of Global Public Health)
Lelo, Patricia (Pediatric Hospital Kalembe Lembe)
Lyamuya, Rita (Morogoro Regional Hospital)
Ogalo, Edith Apondi (Moi Teaching and Referral Hospital)
Odhiambo, Francesca Akoth (Kenya Medical Research Institute)
Haas, Andreas D. (University of Bern. Institute of Social and Preventive Medicine)
Bolton, Carolyn (Centre for Infectious Disease Research in Zambia)
Muhairwe, Josephine (SolidarMed)
Tweya, Hannock (Lighthouse Trust Clinic)
Sylla, Mariam (CHU Gabriel Toure)
D'Almeida, Marceline (Centre National Hospitalier Universitaire Hubert K. Maga)
Renner, Lorna (Korle-Bu Teaching Hospital (Ghana))
Abzug, Mark J. (University of Colorado School of Medicine and Children's Hospital Colorado)
Oleske, James (Rutgers - New Jersey Medical School)
Purswani, Murli (Bronx-Lebanon Hospital Center)
Teasdale, Chloe (Columbia University. Mailman School of Public Health. ICAP at Columbia University)
Nuwagaba-Biribonwoha, Harriet (Columbia University. Mailman School of Public Health. ICAP at Columbia University)
Goodall, Ruth (University College London. MRC Clinical Trials Unit)
Leroy, Valériane (Université Paul Sabatier Toulouse 3. Inserm)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Adolescents living with HIV are subject to multiple co-morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project. Data were collected between 1994 and 2015 from 11 CIPHER networks worldwide. Adolescents with perinatally acquired HIV infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, with at least one height or CD4 count measurement while aged 10-17 years, were included. Growth was measured using height-for-age Z-scores (HAZ, stunting if <-2 SD, WHO growth charts). Linear mixed-effects models were used to study the evolution of each outcome between ages 10 and 17. For growth, sex-specific models with fractional polynomials were used to model non-linear relationships for age at ART initiation, HAZ at age 10 and time, defined as current age from 10 to 17 years of age. A total of 20,939 and 19,557 APH were included for the growth and CD4 analyses, respectively. Half were females, two-thirds lived in East and Southern Africa, and median age at ART initiation ranged from <3 years in North America and Europe to.
Ajuts:	Instituto de Salud Carlos III REDRISRD06/0006/0035 Ministerio de Sanidad y Consumo RD06/0006/0021 Ministerio de Economía y Competitividad RD16/0025/0019 Instituto de Salud Carlos III FISPI19/01530
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adolescent ; CD4 ; Cohort studies ; Growth ; HIV ; Perinatally acquired
Publicat a:	Journal of the International AIDS Society, Vol. 25 (march 2022) , ISSN 1758-2652

DOI: 10.1002/jia2.25871
PMID: 35255197

15 p, 1.9 MB

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