Restoration of the immune function as a complementary strategy to treat Chronic Lymphocytic Leukemia effectively
Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau)
Muñoz Calleja, Cecilia (Hospital Universitario de la Princesa (Madrid))
Terol, Maria Jose (Hospital Clínic Universitari (València))
Hernández Rivas, José Ángel (Hospital Universitario Infanta Leonor)
Villanueva, Miguel (Janssen-Cilag)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Chronic Lymphocytic Leukemia (CLL) is a hematological malignancy characterized by uncontrolled proliferation of B-cells and severe immune dysfunction. Chemo(immuno)therapies (CIT) have traditionally aimed to reduce tumor burden without fully understanding their effects on the immune system. As a consequence, CIT are usually associated with higher risk of infections, secondary neoplasms and autoimmune disorders. A better understanding of the biology of the disease has led to the development of therapeutic strategies which not only act against malignant B-cells but also reactivate and enhance the patient's own anti-tumor immune response. Here, we review the current understanding of the underlying interplay between the malignant cells and non-malignant immune cells that may promote tumor survival and proliferation. In addition, we review the available evidence on how different treatment options for CLL including CIT regimens, small molecular inhibitors (i. e, BTK inhibitors, PI3K inhibitors, BCL-2 inhibitors) and T-cell therapies, affect the immune system and their clinical consequences. Finally, we propose that a dual therapeutic approach, acting directly against malignant B-cells and restoring the immune function is clinically relevant and should be considered when developing future strategies to treat patients with CLL.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Immune function ; Ibrutinib ; CLL ; Chronic Lymphocytic Leukemia
Publicat a:	Journal of Experimental & Clinical Cancer Research : CR, Vol. 40 Núm. 1 (december 2021) , p. 321, ISSN 1756-9966

DOI: 10.1186/s13046-021-02115-1
PMID: 34654437

16 p, 3.1 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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