Changes in Biomarkers of Redox Status in Saliva of Pigs after an Experimental Sepsis Induction
López-Martínez, M.J. (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Escribano Tortosa, Damián (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Ortín-Bustillo, A. (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Franco-Martinez, Lorena (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
González-Aróstegui, Luis Guillermo (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Cerón, José Joaquín (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Rubio, Camila Peres (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Data:	2022
Resum:	Saliva from pigs is gaining attention as an easy sample to obtain, being a source of biomarkers that can provide information on animal health and welfare. This study aimed to evaluate the changes that can occur in salivary biomarkers of the redox status of pigs with an experimentally induced sepsis. For that, the cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of saliva (FRAS), Trolox equivalent antioxidant capacity (TEAC), advanced oxidation protein products (AOPP), ferrous oxidation-xylenol orange (FOX), peroxide activity (POX-Act), and reactive oxygen-derived compounds (d-ROMs) were measured in the saliva of pigs with experimentally induced sepsis by endotoxin lipopolysaccharide (LPS), non-septic inflammation induced by turpentine, and in healthy individuals before and after 3 h, 6 h, 24 h, and 48 h. AOPP, POX-Act, and d-ROMs in the sepsis group were higher than in the control from 3 h to 24 h after the inoculation. CUPRAC, FRAS, and TEAC were higher in sepsis than the control group at 24 h. These changes were of higher magnitude than those that occurred in the turpentine group. In conclusion, our findings reveal that sepsis produces changes in salivary biomarkers of redox status, which opens the possibility of using them as potential biomarkers in this species.
Ajuts:	Ministerio de Economía y Competitividad FJC2019-042475-I Agencia Estatal de Investigación PID2019-105950RB-100
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Antioxidants, Vol. 11 Núm. 7 (july 2022) , p. 1380, ISSN 2076-3921

DOI: 10.3390/antiox11071380
PMID: 35883871

8 p, 1.0 MB

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