Addressing the theoretical and experimental aspects of low-dimensional-materials-based fet immunosensors : a review
Martins, Ernane (Institut Català de Nanociència i Nanotecnologia)
Pinotti, Luis Francisco (Universidade Estadual de Campinas. Faculdade de Engenharia Elétrica e de Computação)
De Carvalho Castro Silva, Cecilia (MackGraphe - Graphene and Nanomaterials Research Center)
Reily Rocha, Alexandre (Universidade Estadual Paulista "Júlio de Mesquita Filho". Instituto de Física Teórica)

Data:	2021
Resum:	Electrochemical immunosensors (EI) have been widely investigated in the last several years. Among them, immunosensors based on low-dimensional materials (LDM) stand out, as they could provide a substantial gain in fabricating point-of-care devices, paving the way for fast, precise, and sensitive diagnosis of numerous severe illnesses. The high surface area available in LDMs makes it possible to immobilize a high density of bioreceptors, improving the sensitivity in biorecognition events between antibodies and antigens. If on the one hand, many works present promising results in using LDMs as a sensing material in EIs, on the other hand, very few of them discuss the fundamental interactions involved at the interfaces. Understanding the fundamental Chemistry and Physics of the interactions between the surface of LDMs and the bioreceptors, and how the operating conditions and biorecognition events affect those interactions, is vital when proposing new devices. Here, we present a review of recent works on EIs, focusing on devices that use LDMs (1D and 2D) as the sensing substrate. To do so, we highlight both experimental and theoretical aspects, bringing to light the fundamental aspects of the main interactions occurring at the interfaces and the operating mechanisms in which the detections are based.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Immunosensor ; Electrochemical ; FET ; Low-dimensional materials
Publicat a:	Chemosensors, Vol. 9, issue 7 (July 2021) , art. 162, ISSN 2227-9040

DOI: 10.3390/chemosensors9070162

30 p, 6.1 MB

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