Graphene oxide prevents lateral amygdala dysfunctional synaptic plasticity and reverts long lasting anxiety behavior in rats
Franceschi Biagioni, Audrey (International School for Advanced Studies (Trieste, Itàlia))
Cellot, Giada (International School for Advanced Studies (Trieste, Itàlia))
Pati, Elisa (International School for Advanced Studies (Trieste, Itàlia))
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia)
Ballesteros, Belén (Institut Català de Nanociència i Nanotecnologia)
Casani, Raffaele (International School for Advanced Studies (Trieste, Itàlia))
Coimbra, Norberto Cysne (Universidade de São Paulo. Department of Pharmacology)
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Ballerini, Laura (International School for Advanced Studies (Trieste, Itàlia))

Data:	2021
Resum:	Engineered small graphene oxide (s-GO) sheets were previously shown to reversibly down-regulate glutamatergic synapses in the hippocampus of juvenile rats, disclosing an unexpected translational potential of these nanomaterials to target selective synapses in vivo. Synapses are anatomical specializations acting in the Central Nervous System (CNS) as functional interfaces among neurons. Dynamic changes in synaptic function, named synaptic plasticity, are crucial to learning and memory. More recently, pathological mechanisms involving dysfunctional synaptic plasticity were implicated in several brain diseases, from dementia to anxiety disorders. Hyper-excitability of glutamatergic neurons in the lateral nucleus of the amygdala complex (LA) is substantially involved in the storage of aversive memory induced by stressful events enabling post-traumatic stress disorder (PTSD). Here we translated in PTSD animal model the ability of s-GO, when stereotaxically administered to hamper LA glutamatergic transmission and to prevent the behavioral response featured in long-term aversive memory. We propose that s-GO, by interference with glutamatergic plasticity, impair LA-dependent memory retrieval related to PTSD.
Ajuts:	European Commission 881603 European Commission 785219 Agencia Estatal de Investigación SEV-2017-0706
Nota:	Altres ajuts: the ICN2 is funded by the CERCA programme, Generalitat de Catalunya.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Graphene-based nanovectors ; Biotechnology of brain disorders ; Synaptic plasticity ; Patch-clamp ; Amygdala
Publicat a:	Biomaterials, Vol. 271 (April 2021) , art. 120749, ISSN 1878-5905

DOI: 10.1016/j.biomaterials.2021.120749

10 p, 5.9 MB

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