Rates and Predictors of Treatment Failure in Staphylococcus aureus Prosthetic Joint Infections According to Different Management Strategies : A Multinational Cohort Study-The ARTHR-IS Study Group
Espíndola, Reinaldo (Hospital Universitario Virgen de Valme (Sevilla, Andalusia))
Vella, Venanzio (GlaxoSmithKline (Itàlia))
Benito, Natividad (Universitat Autònoma de Barcelona. Departament de Medicina)
Mur, Isabel (Universitat Autònoma de Barcelona. Departament de Medicina)
Tedeschi, Sara (IRCCS Azienda Ospedaliero Universitaria di Bologna)
Zamparini, Eleonora (IRCCS Azienda Ospedaliero Universitaria di Bologna)
Hendriks, Johannes G. E. (Máxima MC)
Sorlí, Luisa (Universitat Pompeu Fabra)
Murillo Rubio, Oscar (Institut d'Investigació Biomèdica de Bellvitge)
Soldevila-Boixader, Laura (Institut d'Investigació Biomèdica de Bellvitge)
Scarborough, Mathew (Oxford University Hospitals NHS Foundation Trust (Regne Unit))
Scarborough, Claire (Oxford University Hospitals NHS Foundation Trust)
Kluytmans, Jan (University Medical Center Utrecht. Department of Medical Microbiology)
Ferrari, Mateo Carlo (Humanitas Research Hospital (Itàlia))
Pletz, Mathias (Jena University Hospital (Alemanya))
Mcnamara, Iain (Norfolk and Norwich University Hospital)
Escudero-Sánchez, Rosa (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Arvieux, Cedric (Centre Hospitalier Universitaire de Rennes. Department of Infectious Diseases)
Batailler, Cécile (Croix Rousse Hospital)
Dauchy, Frédéric Antoine (Centre Hospitalier Universitaire de Bordeaux)
Liu, Wai-Yan (Máxima MC)
Lora-Tamayo, Jaime (Hospital Universitario. Department of Internal Medicine)
Praena, Julia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Ustianowski, Andrew (North Manchester General Hospital)
Cinconze, Elisa (GlaxoSmithKline (Itàlia))
Pellegrini, Michele (GlaxoSmithKline (Itàlia))
Rodríguez-Baño, Jesús (Instituto de Biomedicina de Sevilla)
del Toro López, María Dolores (Instituto de Biomedicina de Sevilla)

Data:	2022
Resum:	Guidelines have improved the management of prosthetic joint infections (PJI). However, it is necessary to reassess the incidence and risk factors for treatment failure (TF) of Staphylococcus aureus PJI (SA-PJI) including functional loss, which has so far been neglected as an outcome. A retrospective cohort study of SA-PJI was performed in 19 European hospitals between 2014 and 2016. The outcome variable was TF, including related mortality, clinical failure and functional loss both after the initial surgical procedure and after all procedures at 18 months. Predictors of TF were identified by logistic regression. Landmark analysis was used to avoid immortal time bias with rifampicin when debridement, antibiotics and implant retention (DAIR) was performed. One hundred twenty cases of SA-PJI were included. TF rates after the first and all surgical procedures performed were 32. 8% and 24. 2%, respectively. After all procedures, functional loss was 6. 0% for DAIR and 17. 2% for prosthesis removal. Variables independently associated with TF for the first procedure were Charlson ≥ 2, haemoglobin < 10 g/dL, bacteraemia, polymicrobial infection and additional debridement(s). For DAIR, TF was also associated with a body mass index (BMI).
Ajuts:	Ministerio de Economía y Competitividad RD16/0016/0001 Ministerio de Economía y Competitividad RD16/0016/0002 Ministerio de Economía y Competitividad RD16/0016/0005 Ministerio de Economía y Competitividad RD16/0016/0009 Ministerio de Economía y Competitividad RD16/0016/0011 Ministerio de Economía y Competitividad RD16/0016/0015
Nota:	Altres ajuts: Innovative Medicines Initiative: 115523
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Prosthetic joint infection ; Staphylococcus aureus ; Outcome ; Clinical failure ; Functional failure
Publicat a:	Infectious Diseases and Therapy, Vol. 11 (october 2022) , p. 2177-2203, ISSN 2193-6382

DOI: 10.1007/s40121-022-00701-0
PMID: 36242742

27 p, 1.2 MB

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