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Pàgina inicial > Articles > Articles publicats > Analysis of Parainflammation in Chronic Glaucoma Using Vitreous-OCT Imaging |
Data: | 2021 |
Resum: | Glaucoma causes blindness due to the progressive death of retinal ganglion cells. The immune response chronically and subclinically mediates a homeostatic role. In current clinical practice, it is impossible to analyse neuroinflammation non-invasively. However, analysis of vitreous images using optical coherence tomography detects the immune response as hyperreflective opacities. This study monitors vitreous parainflammation in two animal models of glaucoma, comparing both healthy controls and sexes over six months. Computational analysis characterizes in vivo the hyperreflective opacities, identified histologically as hyalocyte-like Iba-1+ (microglial marker) cells. Glaucomatous eyes showed greater intensity and number of vitreous opacities as well as dynamic fluctuations in the percentage of activated cells (50-250 microns 2) vs. non-activated cells (10-50 microns 2), isolated cells (10 microns 2) and complexes (>250 microns 2). Smaller opacities (isolated cells) showed the highest mean intensity (intracellular machinery), were the most rounded at earlier stages (recruitment) and showed the greatest change in orientation (motility). Study of vitreous parainflammation could be a biomarker of glaucoma onset and progression. |
Ajuts: | Instituto de Salud Carlos III M17/00213 Instituto de Salud Carlos III PI17/01726 Instituto de Salud Carlos III PI17/01946 Instituto de Salud Carlos III PI20/00437 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Optical coherence tomography ; Biomedical imaging ; Image analysis and processing ; Vitreous body ; Glaucoma ; Animal models ; Inflammation |
Publicat a: | Biomedicines, Vol. 9 (november 2021) , ISSN 2227-9059 |
27 p, 5.4 MB |