Interstitial lung disease and anti-myeloperoxidase antibodies : Not a simple association
Sebastiani, Marco (Azienda Ospedaliera Universitaria di Modena (Itàlia))
Luppi, Fabrizio (Università degli Studi di Milano-Bicocca)
Sambataro, Gianluca (Regional Referral Centre for Rare Lung Diseases. A.O.U. "Policlinico-Vittorio Emanuele". Department of Clinical and Experimental Medicine. University of Catania)
Castillo, Diego (Institut d'Investigació Biomèdica Sant Pau)
Cerri, Stefania (Respiratory Unit. University of Modena and Reggio Emilia)
Tomietto, Paola (Rheumatology Unit. University of Trieste)
Cassone, Giulia (PhD Program in Clinical and Experimental Medicine. University of Modena and Reggio Emilia)
Bocchino, Marialuisa (Department of Clinical Medicine and Surgery. Federico II University Hospital)
Atienza-Mateo, Belén (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria))
Cameli, Paolo (University of Siena. Department of Medicine. Surgery & Neurosciences)
Moya, Patricia (Institut d'Investigació Biomèdica Sant Pau)
Faverio, Paola (Università degli Studi di Milano-Bicocca)
Bargagli, Elena (Respiratory Diseases Unit. Department of Medical Sciences. Surgery and Neurosciences. Siena University)
Vancheri, Carlo (Regional Referral Centre for Rare Lung Diseases. A.O.U. "Policlinico-Vittorio Emanuele". Department of Clinical and Experimental Medicine. University of Catania)
Gonzalez-Gay, MA. (Cardiovascular Pathophysiology and Genomics Research Unit. School of Physiology. Faculty of Health Sciences. University of the Witwatersrand)
Clini, Enrico (Respiratory Unit. University of Modena and Reggio Emilia)
Salvarani, Carlo (Azienda Unità Sanitaria Locale di Reggio Emilia. Instituto in tecnologie avanzate e modelli assistenziali in oncologia)
Manfredi, Andreina (Rheumatology Unit. Azienda Ospedaliera Policlinico di Modena. University of Modena and Reggio Emilia)

Data:	2021
Resum:	Anti-neutrophil cytoplasmic antibodies (ANCA), mainly anti-myeloperoxidase (MPO) antibodies, have been frequently identified in patients with idiopathic pulmonary fibrosis (IPF). However, their role remains unclear, and only 7-23% of these patients develops clinically overt vasculitis. We aimed to investigate the clinical, serological, and radiological features and prognosis of anti-MPO-positive interstitial lung disease (ILD) patients. Fifty-eight consecutive patients firstly referred for idiopathic interstitial pneumonia and showing serological positivity of anti-MPO antibodies were retrospectively enrolled. For each patient, clinical data, lung function testing, chest high-resolution computed tomography (HRCT) pattern, and survival were recorded. Thirteen patients developed a rheumatic disease during a median follow-up of 39 months. Usual interstitial pneumonia (UIP) was the most frequent ILD pattern, significantly influencing the patients' survival. In fact, while the 52-week survival of the overall population was 71. 4 ± 7. 5%, significantly higher than IPF, survivals of anti-MPO patients with UIP pattern and IPF were similar. Forced vital capacity and diffusion lung capacity for CO significantly declined in 37. 7 and 41. 5% of cases, respectively, while disease progression at chest HRCT was observed in 45. 2%. A careful clinical history and evaluation should always be performed in ILD patients with anti-MPO antibodies to quickly identify patients who are developing a systemic rheumatic disease.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Interstitial pneumonia ; Idiopathic pulmonary fibrosis ; Vasculitis ; Rheumatic diseases ; Anti-myeloperoxidase antibodies
Publicat a:	Journal of clinical medicine, Vol. 10 Núm. 12 (february 2021) , p. 2548, ISSN 2077-0383

DOI: 10.3390/jcm10122548
PMID: 34207641

8 p, 937.1 KB

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