The Behavioral and Psychological Symptoms of Dementia in down Syndrome Scale (BPSD-DS II) : Optimization and Further Validation
Dekker, Alain D. (Alliade Care Group (Heerenveen, Països Baixos))
Ulgiati, Aurora M. (Alliade Care Group (Heerenveen, Països Baixos))
Groen, Henk (Department of Epidemiology. University of Groningen. University Medical Center Groningen)
Boxelaar, Vicent A. (Center for Information Technology. University of Groningen)
Sacco, Silvia (Institut Jérôme Lejeune)
Falquero, Ségolène (Institut Jérôme Lejeune)
Carfi, Angelo (Policlinico Universitario Agostino Gemelli IRCCS (Roma, Itàlia))
Di Paola, Antonella (Department of Geriatrics. Fondazione Policlinico Universitario Gemelli Irccs)
Benejam, Bessy (Fundació Catalana Síndrome de Down)
Valldeneu, Silvia (Institut d'Investigació Biomèdica Sant Pau)
Fopma, Roelie (Alliade Care Group (Heerenveen, Països Baixos))
Oosterik, Marjo (Aveleijn)
Hermelink, Marloes (De Twentse Zorgcentra)
Beugelsdijk, Gonny (Ipse de Bruggen)
Schippers, Mieke (Ipse de Bruggen)
Henstra, Hepie (Nieuw Woelwijck)
Scholten-Kuiper, Martine (Philadelphia Zorg)
Willink-Vos, Judith (Severinus)
De Ruiter, Lisa (Sherpa)
Willems, Liesbeth (Sprank)
Loonstra-De Jong, Anneke (Vanboeijen)
Coppus, Antonia (Dichterbij)
Tollenaere, Marleen (Department of Neurology and Memory Clinic. Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken)
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau)
Onder, Graziano (Istituto Superiore di Sanitá (Roma, Itàlia). Department of Cardiovascular, Endocrine-metabolic Diseases and Aging)
Rebillat, Anne-Sophie (Institut Jérôme Lejeune)
Van Dam, Debby (Laboratory of Neurochemistry and Behavior. Department of Biomedical Sciences and Institute Born-Bunge. University of Antwerp)
De Deyn, Peter Paul (University Hospital Antwerp (Bèlgica))

Data:	2021
Resum:	Background: People with Down syndrome (DS) are at high risk to develop Alzheimer's disease dementia (AD). Behavioral and psychological symptoms of dementia (BPSD) are common and may also serve as early signals for dementia. However, comprehensive evaluation scales for BPSD, adapted to DS, are lacking. Therefore, we previously developed the BPSD-DS scale to identify behavioral changes between the last six months and pre-existing life-long characteristic behavior. Objective: To optimize and further study the scale (discriminative ability and reliability) in a large representative DS study population. Methods: Optimization was based on item irrelevance and clinical experiences obtained in the initial study. Using the shortened and refined BPSD-DS II, informant interviews were conducted to evaluate 524 individuals with DS grouped according to dementia status: no dementia (DS, N = 292), questionable dementia (DS + Q, N = 119), and clinically diagnosed dementia (DS + AD, N = 113). Results: Comparing item change scores between groups revealed prominent changes in frequency and severity for anxious, sleep-related, irritable, restless/stereotypic, apathetic, depressive, and eating/drinking behavior. For most items, the proportion of individuals displaying an increased frequency was highest in DS + AD, intermediate in DS + Q, and lowest in DS. For various items within sections about anxious, sleep-related, irritable, apathetic, and depressive behaviors, the proportion of individuals showing an increased frequency was already substantial in DS + Q, suggesting that these changes may serve as early signals of AD in DS. Reliability data were promising. Conclusion: The optimized scale yields largely similar results as obtained with the initial version. Systematically evaluating BPSD in DS may increase understanding of changes among caregivers and (timely) adaptation of care/treatment.
Ajuts:	Ministerio de Economía y Competitividad PI14/01126 Instituto de Salud Carlos III PI17/01019
Nota:	Altres ajuts: Research School Behavioral and Cognitive Neurosciences (RUG/UMCG); Gratama Stichting/Stichting Groninger Universiteitsfonds (2015-04); Research Foundation Flanders (G053218N); Fondo Europeo de Desarrollo Regional (FEDER); National Institutes of Health (NIA grants 1R01AG056850-01A1, R21AG056974, R01AG061566); Fundació La Marató de TV3 (20141210); Fundació Catalana Síndrome de Down; Fundació Víctor Grífols i Lucas; Generalitat de Catalunya (SLT006/17/00119).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer's disease ; Behavior ; Behavioral and psychological symptoms of dementia ; Dementia ; Down syndrome ; Intellectual disabilities ; Neuropsychiatric symptoms ; Trisomy 21
Publicat a:	Journal of Alzheimer's disease, Vol. 81 Núm. 4 (2021) , p. 1505-1527, ISSN 1875-8908

DOI: 10.3233/JAD-201427
PMID: 33967040

23 p, 1.1 MB

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