![]() |
|||||||||||||||
![]() |
Cerca | Lliura | Ajuda | Servei de Biblioteques | Sobre el DDD | Català English Español |
Pàgina inicial > Articles > Articles publicats > Extracellular vesicles, the emerging mirrors of brain physiopathology |
Data: | 2023 |
Resum: | Extracellular vesicles are secreted by a wide variety of cells, and their primary functions include intercellular communication, immune responses, human reproduction, and synaptic plasticity. Their molecular cargo reflects the physiological processes that their cells of origin are undergoing. Thus, many studies have suggested that extracellular vesicles could be a promising biomarker tool for many diseases, mainly due to their biological relevance and easy accessibility to a broad range of body fluids. Moreover, since their biological composition leads them to cross the blood-brain barrier bidirectionally, growing evidence points to extracellular vesicles as emerging mirrors of brain diseases processes. In this regard, this review explores the biogenesis and biological functions of extracellular vesicles, their role in different physiological and pathological processes, their potential in clinical practice, and the recent outstanding studies about the role of exosomes in major human brain diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or brain tumors. |
Ajuts: | Ministerio de Ciencia e Innovación PID2021-122473OA-I00 Ministerio de Ciencia e Innovación PID2021-123462OB-I00 Agencia Estatal de Investigación PID2019-106625RB-I00 Instituto de Salud Carlos III CD22/00125 Instituto de Salud Carlos III PI17/01474 Instituto de Salud Carlos III PI19/00335 Instituto de Salud Carlos III PI22/01403 Instituto de Salud Carlos III PI22/00258 Instituto de Salud Carlos III CB06/05/2004 Instituto de Salud Carlos III CB18/05/00010 |
Nota: | Altres ajuts: The support of Fundación bancaria "La Caixa" and Grífols SA (GR@ACE project). |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Exosomes ; Extracellular vesicles ; Alzheimer's disease ; Parkinson's disease ; Glioblastoma ; Multiple sclerosis, amyotrophic lateral sclerosis ; Neurodegenerative diseases |
Publicat a: | International journal of biological sciences, Vol. 19, issue 3 (2023) , p. 721-743, ISSN 1449-2288 |
23 p, 2.5 MB |