Mechanisms of epigenetic regulation of transcription by lncRNAs in plants
Tremblay, Benjamin Jean-Marie (Centre de Recerca en Agrigenòmica)
Qüesta, Julia I. (Centre de Recerca en Agrigenòmica)

Data:	2023
Resum:	Long noncoding RNAs (lncRNAs) are an ubiquitous feature of eukaryotic genomes and in recent decades have been shown to be highly abundant and varied. Many prominent examples have been described as having essential roles in regulating the expression of genes in different developmental and environmental contexts. As a result, much work has been done on elucidating the mechanisms by which they modulate the expression of protein coding genes. In this review, we focus on those which have been characterized in plants. We specifically examine common epigenetic mechanisms that regulate gene expression at the level of transcription. In this regard, we focus on the lncRNAs in plants that have primarily been associated with controlling the chromatin environment of genes at the level of modifications, RNA POLYMERASE II (RNAPII) processivity and efficiency of transcription, and mediating the formation of transcriptionally activating and repressive chromatin loops. We discuss open questions in plant lncRNA epigenetic regulation and opportunities for future study of functionally significant lncRNAs with yet-unknown epigenetic mechanisms.
Ajuts:	Ministerio de Economía y Competitividad SEV-2015-0533 Ministerio de Ciencia e Innovación PRE-2019-090156
Nota:	Altres ajuts: Junior Leader Fellowship [LCF/BQ/PI19/11690003] from "laCaixa" Foundation [ID100010434]
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Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Chromatin ; Epigenetics ; Gene regulation ; Lncrnas ; Plants ; RNA polymerase
Publicat a:	IUBMB Life, Vol. 75, Issue 5 (May 2023) , p. 427-439, ISSN 1521-6551

DOI: 10.1002/iub.2681

Postprint 25 p, 701.9 KB

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