Synthesis of isothiocineole and application in multigram-scale sulfur ylide mediated asymmetric epoxidation and aziridination
Fearraigh, Martin P.Ó. (University College Dublin. Centre for Synthesis and Chemical Biology)
Matlock, Johnathan V. (University of Bristol)
Illa, Ona (Universitat Autònoma de Barcelona. Departament de Química)
McGarrigle, Eoghan M. (University College Dublin. Centre for Synthesis and Chemical Biology)
Aggarwal, Varinder K. (University of Bristol)

Data:	2018
Resum:	The synthesis of the chiral sulfide isothiocineole from limonene and elemental sulfur on multi-gram scale and its alkylation to make >50 g of the corresponding benzylsulfonium salt are described. The application of this salt to the sulfur ylide-mediated asymmetric epoxidation of aldehydes and the asymmetric aziridination of imines on a >5 g scale is demonstrated.
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Asymmetric aziridination ; Asymmetric epoxidation ; Chiral sulfide ; Sulfur ylide
Publicat a:	Synthesis, Vol. 50, Issue 17 (September 2018) , p. 3337-3343, ISSN 1437-210X

DOI: 10.1055/s-0037-1609580

Postprint 7 p, 896.4 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències > Synthesis of Bioactive Organic Compounds and Functional Materials (SynOrgFUN)
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