New insights into the genetic etiology of Alzheimer's disease and related dementias
Bellenguez, Céline (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement)
Küçükali, Fahri (University of Antwerp)
Jansen, Iris E. (Department of Complex Trait Genetics. Center for Neurogenomics and Cognitive Research. Amsterdam Neuroscience. Vrije University)
Kleineidam, Luca (German Center for Neurodegenerative Diseases (DZNE))
Moreno-Grau, Sonia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Amin, Najaf (Nuffield Department of Population Health.Oxford University)
Naj, Adam C. (University of Pennsylvania Perelman School of Medicine)
Campos-Martin, Rafael (Universität zu Köln. Department of Psychiatry and Psychotherapy)
Grenier-Boley, Benjamin (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement)
Andrade, Victor (Universität zu Köln. Department of Psychiatry and Psychotherapy)
Holmans, Peter (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University)
Boland, Anne (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine)
Damotte, Vincent (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement)
van der Lee, Sven J. (Vrije Universiteit Amsterdam)
Costa, Marcos R. (Brain Institute. Universidade Federal do Rio Grande do Norte.)
Kuulasmaa, Teemu (Institute of Biomedicine. University of Eastern Finland)
Yang, Qiong (Framingham Heart Study)
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Bis, Joshua C. (Cardiovascular Health Research Unit. Department of Medicine. University of Washington)
Yaqub, Amber (Erasmus Medical Center. Department of Epidemiology)
Prokic, Ivana (Erasmus Medical Center. Department of Epidemiology)
Chapuis, Julien (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement)
Ahmad, Shahzad (LACDR)
Giedraitis, Vilmantas (Department of Public Health and Carins Sciences/Geriatrics. Uppsala University)
Aarsland, Dag (Institute of Psychiatry. Psychology & Neuroscience)
García-González, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Abdelnour, Carla (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Alarcón-Martín, Emilio (Department of Surgery. Biochemistry and Molecular Biology. School of Medicine. University of Málaga)
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau)
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Alvarez, Ignacio (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Alvarez, Victoria (Hospital Universitario Central de Asturias)
Armstrong, Nicola (Curtin University)
Tsolaki, Anthoula (Alzheimer Hellas)
Antúnez, Carmen (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Appollonio, Ildebrando (Neurology Unit. San Gerardo Hospital)
Arcaro, Marina (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Archetti, Silvana (Department of Laboratory Diagnostics. III Laboratory of Analysis. Brescia Hospital)
Pastor, Alfonso A. (Institut de Recerca Biomèdica de Lleida)
Arosio, Beatrice (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Athanasiu, Lavinia (NORMENT Centre. University of Oslo)
Bailly, Henri (EA 4468. Université de Paris. APHP. Hôpital Broca)
Banaj, Nerisa (IRCCS Santa Lucia Foundation)
Baquero, Miquel (Hospital Universitari i Politècnic La Fe (València))
Barral, Sandra (Gertrude H. Sergievsky Center. Columbia University)
Beiser, Alexa (Boston University and the NHLBI's Framingham Heart Study)
Pastor, Ana Belén (CIEN Foundation/Queen Sofia Foundation Alzheimer Center)
Below, Jennifer E. (Human Genetics Center. Department of Epidemiology. Human Genetics. and Environmental Sciences. School of Public Health. The University of Texas Health Science Center at Houston)
Benchek, Penelope (Department of Population and Quantitative Health Sciences. Case Western Reserve University)
Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli (Brescia, Itàlia))
Berr, Claudine (Université Montpellier, INSERM, Institute for Neurosciences of Montpellier)
Besse, Céline (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine)
Bessi, Valentina (Azienda Ospedaliero-Universitaria Careggi)
Binetti, Giuliano (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli (Brescia, Itàlia). MAC - Memory Clinic)
Bizarro, Alessandra (Fondazione Policlinico "A. Gemelli" IRCCS)
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau)
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Boerwinkle, Eric (Baylor College of Medicine (Houston, Estats Units d'Amèrica))
Borroni, Barbara (Centre for Neurodegenerative Disorders. Department of Clinical and Experimental Sciences. University of Brescia)
Boschi, Silvia (Department of Neuroscience "Rita Levi Montalcini". University of Torino)
Bossù, Paola (IRCCS Santa Lucia Foundation (Roma, Itàlia))
Bråthen, Geir (Department of Neuromedicine and Movement Science. Norwegian University of Science and Technology)
Bressler, Jan (School of Public Health. University of Texas Health Science Center at Houston)
Bresner, Catherine (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University)
Brodaty, Henry (Dementia Centre for Research Collaboration. School of Psychiatry. University of New South Wales)
Brookes, Keeley J. (Biosciences. School of Science and Technology. Nottingham Trent University)
Brusco, Luis Ignacio (Hospital Interzonal General de Agudos Eva Perón)
Buiza-Rueda, Dolores (Erasmus Medical Center. Department of Neurology)
Bûrger, Katharina (German Center for Neurodegenerative Diseases (DZNE))
Burholt, Vanessa (Swansea University. Wales Centre for Ageing & Dementia Research)
Bush, William (Department of Population & Quantitative Health Sciences. Case Western Reserve University)
Calero, Miguel (UFIEC. Instituto de Salud Carlos III)
Cantwell, Laura B. (Department of Pathology and Laboratory Medicine. University of Pennsylvania)
Chene, Geneviève (Pole Santé Publique. CHU de Bordeaux)
Chung, Jaeyoon (Department of Medicine (Biomedical Genetics). Boston University School of Medicine)
Frosch, M.P. (C.S. Kubik Laboratory for Neuropathology. Massachusetts General Hospital)
Fulton-Howard, B. (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Galasko, D.R. (Department of Neurosciences. University of California San Diego)
Gamboa, A. (Department of Health Management and Policy. School of Public Health. University of North Texas Health Science Center)
Gearing, M. (Emory Alzheimer's Disease Center. Emory University)
Geschwind, D.H. (NeuroGenomics and Informatics. Washington University in St. Louis)
Ghetti, Bernardino (Department of Pathology and Laboratory Medicine. Indiana University)
Cuccaro, MichaelL. (The John P. Hussman Institute for Human Genomics. University of Miami)
Gilbert, J.R. (The John P. Hussman Institute for Human Genomics. University of Miami)
Grabowski, T.J. (Department of Radiology. University of Washington)
Graff-Radford, N.R. (Mayo Clinic Florida (Jacksonville, Estats Units d'Amèrica). Department of Neurology)
Grant, S.F.A. (Department of Genetics. Perelman School of Medicine. University of Pennsylvania)
Green, R.C. (Division of Genetics. Department of Medicine and Partners Center for Personalized Genetic Medicine. Brigham and Women's Hospital and Harvard Medical School)
Growdon, J.H. (Harvard Medical School)
Haines, J.L. (Department of Population & Quantitative Health Sciences. Case Western Reserve University)
Hakonarson, Hakon (Division of Human Genetics. Department of Pediatrics. Perelman School of Medicine. University of Pennsylvania)
Hall, J. (Department of Pharmacology and Neuroscience. University of North Texas Health Science Center)
Hamilton, R.L. (Department of Pathology (Neuropathology). University of Pittsburgh)
Carracedo, Ángel (Fundación Pública Galega de Medicina Xenómica- CIBERER-IDIS. University of Santiago de Compostela)
Harari, O. (Department of Psychiatry. Washington University in St. Louis)
Harrell, L.E. (Department of Neurology. University of Alabama at Birmingham)
Haut, J. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine)
Head, Elizabeth (Department of Pathology and Laboratory Medicine. University of California Irvine)
Henderson, V.W. (Department of Neurology and Neurological Sciences. Stanford University)
Hernandez, M. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center)
Hohman, T. (Vanderbilt Memory and Alzheimer's Center. Department of Neurology. Vanderbilt University Medical Center)
Honig, L.S. (Taub Institute on Alzheimer's Disease and the Aging Brain. Department of Neurology. Columbia University)
Huebinger, R.M. (Department of Surgery. University of Texas Southwestern Medical Center)
Huentelman, M.J. (Neurogenomics Division. Translational Genomics Research Institute)
Cecchetti, Roberta (Institute of Gerontology and Geriatrics. Department of Medicine and Surgery. University of Perugia)
Hulette, C.M. (Department of Pathology. Duke University)
Hyman, B.T. (Harvard Medical School)
Hynan, L.S. (Department of Neurological Surgery. University of Texas Southwestern Medical Center)
Ibanez, L. (Hope Center Program on Protein Aggregation and Neurodegeneration. Washington University School of Medicine)
Jarvik, G.P. (Department of Genome Sciences. University of Washington)
Jayadev, S. (Departments of Neurology and Epidemiology. University of Washington)
Jin, L.W. (Department of Pathology and Laboratory Medicine. University of California. Davis)
Johnson, K. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center)
Johnson, Leigh A. (University of North Texas Health Science Center)
Kamboh, M.I. (Alzheimer's Disease Research Center. University of Pittsburgh)
Cervera Carles, Laura (Institut d'Investigació Biomèdica Sant Pau)
Karydas, A.M. (Department of Neurology. University of California San Francisco)
Katz, M.J. (Albert Einstein College of Medicine (Nova York, Estats Units d'Amèrica))
Kaye, J.A. (Portland Veterans Affairs Medical Center)
Keene, C.D. (Department of Laboratory Medicine and Pathology. University of Washington)
Khaleeq, A. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Alzheimer's Disease and Memory Disorders Center)
Kim, R. (Department of Pathology and Laboratory Medicine. University of California Irvine)
Knebl, J. (Department of Health Behavior and Health Systems. University of North Texas Health Science Center)
Kowall, N.W. (Department of Pathology. Boston University)
Kramer, J.H. (Department of Neuropsychology. University of California San Francisco)
Kuksa, P.P. (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine)
Charbonnier, Camille (Department of Genetics and CNR-MAJ. Normandie University. UNIROUEN. INSERM U1245. CHU Rouen)
LaFerla, Frank M. (Department of Neurobiology and Behavior. University of California Irvine)
Lah, J.J. (Emory University. Department of Neurology)
Larson, E.B. (Kaiser Permanente Washington Health Research Institute)
Lee, C.Y. (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine)
Lee, E.B. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine)
Lerner, A. (Department of Population and Quantitative Health Sciences. Case Western Reserve University)
Leung, Y.Y. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine)
Leverenz, J.B. (Cleveland Clinic Lou Ruvo Center for Brain Health)
Levey, A.I. (Emory University. Department of Neurology)
Li, Mengyao (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine)
Chen, Hung-Hsin (Division of Genetic Medicine. Vanderbilt University)
Lieberman, A.P. (Department of Pathology. University of Michigan)
Lipton, R.B. (Albert Einstein College of Medicine (Nova York, Estats Units d'Amèrica))
Logue, M. (National Center for PTSD at Boston VA Healthcare System)
Lyketsos, C.G. (Department of Psychiatry. Johns Hopkins University)
Malamon, J. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine)
Mains, D. (Department of Health Management and Policy. School of Public Health. University of North Texas Health Science Center)
Marson, D.C. (Department of Neurology. University of Alabama at Birmingham)
Martiniuk, F. (Department of Medicine (Pulmonary). New York University)
Mash, D.C. (Department of Neurology. Miller School of Medicine. University of Miami)
Masliah, E. (Department of Pathology. University of California San Diego)
Chillotti, Caterina (Unit of Clinical Pharmacology. University Hospital of Cagliari)
Massman, P. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Alzheimer's Disease and Memory Disorders Center)
Masurkar, A. (Department of Psychiatry. New York University)
McCormick, W.C. (Department of Medicine. University of Washington)
McCurry, S.M. (School of Nursing Northwest Research Group on Aging. University of Washington)
McDavid, A.N. (Fred Hutchinson Cancer Research Center)
McDonough, S. (Pfizer Worldwide Research and Development)
McKee, A.C. (Department of Pathology. Boston University)
Mesulam, M. (Cognitive Neurology and Alzheimer's Disease Center. Northwestern University Feinberg School of Medicine)
Mez, J. (Institute of Biomedicine. University of Eastern Finland)
Miller, B.L. (Weill Institute for Neurosciences. Memory and Aging Center. University of California. San Francisco)
Ciccone, Simona (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Miller, C.A. (Department of Pathology. University of Southern California)
Miller, J.W. (Department of Pathology and Laboratory Medicine. University of California. Davis)
Montine, T.J. (Department of Pathology. Stanford University School of Medicine)
Monuki, E.S. (Department of Pathology and Laboratory Medicine. University of California Irvine)
Morris, J.C. (Department of Neurology. Washington University at St. Louis)
Myers, A.J. (Department of Psychiatry and Behavioral Sciences. Miller School of Medicine. University of Miami)
Nguyen, Thanh N. (Department of Neurology. University of Texas Southwestern Medical Center)
O'Bryant, S. (Institute for Translational Research. University of North Texas Health Science Center)
Olichney, J.M. (Center for Mind and Brain and Department of Neurology. University of California. Davis)
Ory, M. (Center for Population Health and Aging. Texas A&M University Health Science Center)
Claassen, Jurgen A. H. R. (Radboudumc Alzheimer Center. Department of Geriatrics. Radboud University Medical Center)
Palmer, R. (Department of Family and Community Medicine. University of Texas Health Science Center San Antonio)
Parisi, J.E. (Mayo Clinic (Rochester, Estats Units d'Amèrica). Department of Laboratory Medicine and Pathology)
Paulson, H.L. (Michigan Alzheimer's Disease Center. University of Michigan)
Pavlik, V. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Alzheimer's Disease and Memory Disorders Center)
Paydarfar, D. (Department of Neurology. Dell Medical School. University of Texas at Austin)
Pérez Solà, Víctor (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center)
Peskind, E. (Department of Psychiatry and Behavioral Sciences. University of Washington School of Medicine)
Phillips-Cremins, J.E. (Department of Bioengineering. University of Pennsylvania)
Pierce, A. (Department of Neurology. University of California. Irvine)
Polk, M. (Alzheimer's Disease Center. New York University)
Clark, Christopher (Institute for Regenerative Medicine. University of Zürich)
Poon, W.W. (Institute for Memory Impairments and Neurological Disorders. University of California. Irvine)
Potter, H. (Department of Neurology. University of Colorado School of Medicine)
Qu, L. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine)
Quiceno, M. (University of North Texas Health Science Center (Fort Worth, Estats Units d'Amèrica))
Quinn, J.F. (Portland Veterans Affairs Medical Center)
Raj, A. (USF Health Byrd Alzheimer's Institute. University of South Florida)
Raskind, M. (Department of Psychiatry and Behavioral Sciences. University of Washington School of Medicine)
Reiman, E.M. (Department of Psychiatry. University of Arizona)
Reisberg, B. (Alzheimer's Disease Center. New York University)
Reisch, J.S. (Department of Population and Data Sciences. University of Texas Southwestern Medical Center)
Conti, Elisa (School of Medicine and Surgery. University of Milano-Bicocca)
Ringman, J.M. (Department of Neurology. University of Southern California)
Roberson, E.D. (Department of Neurology. University of Alabama at Birmingham)
Rodriguear, M. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Alzheimer's Disease and Memory Disorders Center)
Rogaeva, Ekaterina (Tanz Centre for Research in Neurodegenerative Disease. University of Toronto)
Rosen, H.J. (Department of Neurology. University of California San Francisco)
Rosenberg, R.N. (Department of Neurology. University of Texas Southwestern Medical Center)
Royall, D.R. (Department of Family and Community Medicine. University of Texas Health Science Center San Antonio)
Sager, M.A. (Department of Medicine. University of Wisconsin)
Sano, M. (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica). Department of Psychiatry)
Saykin, A.J. (Department of Radiology and Imaging Sciences. Indiana University)
Corma Gómez, Anaïs (Hospital Universitario Virgen de Valme (Sevilla, Andalusia))
Schneider, J.A. (Department of Pathology (Neuropathology). Rush University Medical Center)
Schneider, L.S. (Department of Psychiatry. University of Southern California)
Seeley, W.W. (Department of Neurology. University of California San Francisco)
Slifer, S.H. (The John P. Hussman Institute for Human Genomics. University of Miami)
Small, S. (Gertrude H. Sergievsky Center. Columbia University)
Smith, A.G. (USF Health Byrd Alzheimer's Institute. University of South Florida)
Smith, J.P. (Department of Population and Data Sciences. University of Texas Southwestern Medical Center)
Song, Y.E. (Department of Population and Quantitative Health Sciences. Case Western Reserve University)
Sonnen, J.A. (Department of Laboratory Medicine and Pathology. University of Washington)
Spina, S. (Department of Pathology and Laboratory Medicine. Indiana University)
Costantini, Emanuele (Department of Neuroscience. Catholic University of Sacred Heart. Fondazione Policlinico Universitario A. Gemelli IRCCS)
St George Hyslop, Peter (University of Toronto)
Stern, R.A. (Institute of Biomedicine. University of Eastern Finland)
Stevens, A.B. (College of Medicine. Texas A&M University Health Science Center)
Strittmatter, S.M. (Program in Cellular Neuroscience. Neurodegeneration and Repair. Yale University School of Medicine)
Sultzer, D. (Department of Psychiatry and Human Behavior. University of California. Irvine)
Swerdlow, R.H. (University of Kansas Alzheimer's Disease Center. University of Kansas Medical Center)
Tanzi, Rudolph E. (Harvard Medical School)
Tilson, J.L. (Renaissance Computing Institute. University of North Carolina at Chapel Hill)
Trojanowski, John Q. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine)
Troncoso, J.C. (Department of Pathology. Johns Hopkins University)
Custodero, Carlo (University of Bari. "A. Moro")
Tsuang, D.W. (Department of Psychiatry and Behavioral Sciences. University of Washington School of Medicine)
Valladares, Otto (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine)
Van Deerlin, V.M. (Department of Biostatistics. Epidemiology. and Informatics. Penn Neurodegeneration Genomics Center. University of Pennsylvania Perelman School of Medicine)
van Eldik, L.J. (Sanders-Brown Center on Aging. Department of Biostatistics. University of Kentucky)
Vassar, R. (Cognitive Neurology and Alzheimer's Disease Center. Northwestern University Feinberg School of Medicine)
Vinters, H.V. (Department of Pathology and Laboratory Medicine. University of California. Los Angeles)
Vonsattel, J.P. (Taub Institute on Alzheimer's Disease and the Aging Brain. Department of Neurology. Columbia University)
Weintraub, S. (Department of Psychiatry and Behavioral Sciences. Northwestern University Feinberg School of Medicine)
Welsh-Bohmer, K.A. (Department of Psychiatry and Behavioral Sciences. Duke University)
Whitehead, P.L. (The John P. Hussman Institute for Human Genomics. University of Miami)
Daian, Delphine (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine)
Wijsman, E.M. (Department of Biostatistics. University of Washington)
Wilhelmsen, K.C. (Department of Genetics. University of North Carolina at Chapel Hill)
Williams, B. (Wake Forest School of Medicine (Winston-Salem, Estats Units d'Amèrica). Section of Gerontology and Geriatric Medicine Research)
Williamson, J. (Taub Institute on Alzheimer's Disease and the Aging Brain. Department of Neurology. Columbia University)
Wilms, H. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center)
Wingo, T.S. (Emory University. Department of Neurology)
Wisniewski, Thomas M. (Center for Cognitive Neurology and Departments of Neurology and Pathology. New York University Grossman School of Medicine)
Woltjer, Randy L. (Department of Pathology. Oregon Health and Science University)
Woon, M. (Department of Psychiatry. University of Texas at Austin/Dell Medical School)
Wright, C.B. (Evelyn F. McKnight Brain Institute. Department of Neurology. Miller School of Medicine. University of Miami)
Dalmasso, Maria Carolina (Universität zu Köln. Department of Psychiatry and Psychotherapy)
Wu, C.K. (Departments of Neurology. Pharmacology and Neuroscience. Texas Tech University Health Science Center)
Younkin, Steven G. (Mayo Clinic Florida (Jacksonville, Estats Units d'Amèrica). Department of Neurology)
Yu, C.E. (Department of Medicine. University of Washington)
Yu, L. (Rush Alzheimer's Disease Center. Rush University Medical Center)
Zhang, Yu (Children's Hospital of Philadelphia (Pennsilvània))
Zhao, Y. (IRCCS Santa Lucia Foundation)
Zhu, X. (Department of Pathology. Case Western Reserve University)
Adams, Hieab H. H. (Université de Lille. INSERM. CHU Lille. Institut Pasteur Lille. U1167-RID-AGE. Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement)
Akinyemi, Rufus (Centre for Genomic and Precision Medicine. College of Medicine. UI)
Ali, M. (Washington University at St. Louis)
Daniele, Antonio (Department of Neuroscience. Catholic University of Sacred Heart. Fondazione Policlinico Universitario A. Gemelli IRCCS)
Aparicio, H.J. (Department of Neurology. Boston University School of Medicine)
Bahadori, M. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center)
Becker, James T. (University of Pittsburgh)
Breteler, M. (German Center for Neurodegenerative Diseases (DZNE))
Chasman, D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Chauhan, G. (INSERM U1219. University of Bordeaux)
Comic, H. (Erasmus Medical Center. Department of Epidemiology)
Cox, S. (University of Edinburgh)
Cupples, A.L. (Department of Biostatistics. Boston University School of Public Health)
Davies, Gail (Centre for Cognitive Ageing and Cognitive Epidemiology. University of Edinburgh)
Dardiotis, Efthimios (School of Medicine. University of Thessaly)
DeCarli, C.S. (Department of Neurology and Center for Neuroscience. University of California. Davis)
Duperron, M.G. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM)
Dupuis, J. (Department of Biostatistics. Boston University School of Public Health)
Evans, T. (Erasmus Medical Center. Department of Epidemiology)
Fan, F. (University of Pittsburgh)
Fitzpatrick, A. (Department of Family Medicine. University of Washington)
Fohner, A.E. (Cardiovascular Health Research Unit. Department of Medicine. University of Washington)
Ganguli, M. (University of Pittsburgh)
Geerlings, M. (University Medical Center Utrecht)
Glatt, Stephen J. (Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab). Department of Psychiatry and Behavioral Sciences. SUNY Upstate Medical University (Syracuse, Estats Units d'Amèrica))
Dartigues, Jean-François (Bordeaux Population Health Research Center. University Bordeaux. INSERM)
Gonzalez, H.M. (University of California. San Diego)
Goss, M. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center)
Grabe, H. (Department of Psychiatry and Psychotherapy. University Medicine Greifswald)
Habes, M. (Department of Radiology. University of Texas Health Science Center at San Antonio)
Heckbert, S.R. (School of Public Health. University of Texas Health Science Center at Houston)
Hofer, E. (Clinical Division of Neurogeriatrics. Department of Neurology. Medical University of Graz)
Hong, E. (University of Maryland)
Hughes, T. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center)
Kautz, T.F. (Department of General Medicine. University of Texas Health Science Center)
Knol, M. (Erasmus Medical Center. Department of Epidemiology)
De Deyn, Peter Paul (Department of Neurology. University Medical Center Groningen)
Kremen, W. (Erasmus Medical Center. Department of Epidemiology)
Lacaze, Paul (Monash University Clayton Campus)
Lahti, J. (University of Helsinki)
Grand, Q.L. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM)
Litkowski, E. (University of Colorado Anschutz Medical Center)
Li, S. (Department of Biostatistics. Boston University School of Public Health)
Liu, Daijun (German Center for Neurodegenerative Diseases (DZNE))
Liu, X. (Department of Biostatistics. Boston University School of Public Health)
Loitfelder, M. (Medical University of Graz)
Manning, A. (Massachusetts General Hospital. Harvard University)
de Paiva Lopes, Katia (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica). Department of Psychiatry)
Maillard, P. (Imaging of Dementia and Aging (IDeA) Laboratory. Department of Neurology. University of California. Davis)
Marioni, R. (University of Staffmail)
Mazoyer, B. (University of Bordeaux. IMN)
van Lent, D.M. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center)
Mei, H. (University of Mississippi Medical Center)
Mishra, Aniket (Université de Bordeaux)
Nyquist, P. (Johns Hopkins University School of Medicine)
O'Connell, J. (University of Maryland)
Patel, Y. (University of Toronto)
Paus, T. (University of Montreal. Centre Hospitalier Universitaire Saint-Justine)
de Witte, Lot D. (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica). Department of Psychiatry)
Pausova, Z. (Hospital for Sick Children. University of Toronto)
Raikkonen-Talvitie, K. (University of Helsinki)
Riaz, M. (Monash University Clayton Campus)
Rich, S. (Monash University Clayton Campus)
Romero, J. (Boston Medical Center)
Roshchupkin, G. (Erasmus MC. Department of Epidemiology)
Saba, Y. (Gottfried Schatz Research Center. Department of Molecular Biology and Biochemistry. Medical University of Graz)
Sargurupremraj, M. (Gottfried Schatz Research Center. Department of Molecular Biology and Biochemistry. Medical University of Graz)
Schmidt, H. (Gottfried Schatz Research Center. Department of Molecular Biology and Biochemistry. Medical University of Graz)
Schmidt, Reinhold (Clinical Division of Neurogeriatrics. Department of Neurology. Medical University of Graz)
Debette, Stéphanie (Bordeaux Population Health Research Center. University Bordeaux. INSERM)
Shulman, J.M. (Baylor College of Medicine (Houston, Estats Units d'Amèrica))
Smith, J. (Department of Epidemiology. School of Public Health. University of Michigan)
Sekhar, H. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM)
Rajula, R. (Bordeaux Population Health Research Center. Team VIN-TAGE. UMR 1219. University of Bordeaux. INSERM)
Shin, J. (Hospital for Sick Children. University of Toronto)
Simino, J. (University of Mississippi Medical Center)
Sliz, E. (University of Mississippi Medical Center)
Teumer, A. (Institute for Community Medicine. University Medicine Greifswald)
Thomas, A. (University of North Carolina)
Tin, A. (University of Mississippi Medical Center)
Deckert, Jürgen (Department of Psychiatry. Psychosomatics and Psychotherapy. Center of Mental Health. University Hospital)
Tucker-Drob, E. (University of Texas)
Vojinovic, Dina (Erasmus Medical Center. Department of Epidemiology)
Wang, Yanbing (German Center for Neurodegenerative Diseases (DZNE))
Weinstein, Galit (Clinical Division of Neurogeriatrics. Department of Neurology. Medical University of Graz)
Williams, Dylan (Karolinska Institutet (Estocolm, Suècia))
Wittfeld, Katharina (German Center for Neurodegenerative Diseases (DZNE))
Yanek, Lisa R. (GeneSTAR Research Program. Department of Neurology. Johns Hopkins University School of Medicine)
Yang, Yunju (Institute of Molecular Medicine. University of Texas Health Science Center at Houston McGovern Medical School)
Farrer, L.A. (Department of Neurology. Boston University School of Medicine)
Psaty, B.M. (Department of Health Service. University of Washington)
del Ser, Teodoro (CIEN Foundation/Queen Sofia Foundation Alzheimer Center)
Ghanbari, M. (Erasmus Medical Center. Department of Epidemiology)
Raj, T. (Nash Family Department of Neuroscience & Friedman Brain Institute. Icahn School of Medicine at Mount Sinai)
Sachdev, Perminder S. (University of New South Wales)
Mather, Karen A. (Centre for Healthy Brain Ageing. School of Psychiatry. Faculty of Medicine. University of New South Wales)
Jessen, Frank (German Center for Neurodegenerative Diseases (DZNE))
Ikram, M. Arfan (Erasmus Medical Center. Department of Epidemiology)
de Mendonça, Alexandre (Universidade de Lisboa)
Hort, J. (Memory Clinic. Department of Neurology. Charles University. 2nd Faculty of Medicine and Motol University Hospital)
Tsolaki, Magda (Aristotle University of Thessaloniki (Grècia))
Pericak-Vance, Margaret A. (AI Virtanen Institute for Molecular Sciences. University of Eastern Finland)
Denning, Nicola (UKDRI@ Cardiff. School of Medicine. Cardiff University)
Amouyel, Philippe (Institut Pasteur Lille (França))
Williams, J. (UKDRI@ Cardiff. School of Medicine. Cardiff University)
Frikke-Schmidt, Ruth (University of Copenhagen (Dinamarca))
Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Deleuze, J.F. (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine)
Rossi, Giacomina (Fondazione IRCCS Istituto Neurologico Carlo Besta (Milà, Itàlia))
Seshadri, S. (Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases. University of Texas Health Sciences Center)
Andreassen, Ole A. (NORMENT Centre. University of Oslo)
Ingelsson, Martin (Department of Public Health and Carins Sciences/Geriatrics. Uppsala University)
Hiltunen, M. (Brain Institute. Universidade Federal do Rio Grande do Norte.)
DeStefano, Anita L. (Department of Neurology. Boston University School of Medicine)
Sleegers, Kristel (Department of Biomedical Sciences. University of Antwerp)
Schellenberg, G.D. (Department of Pathology and Laboratory Medicine. University of Pennsylvania Perelman School of Medicine)
van Duijn, C.M. (Nuffield Department of Population Health.Oxford University)
Sims, Rebecca (MRC Centre for Neuropsychiatric Genetics and Genomics. Division of Psychological Medicine and Clinical Neuroscience. School of Medicine. Cardiff University)
van der Flier, Wiesje M. (Amsterdam University Medical Center (UMC). Department of Neurology)
Ruiz Laza, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Ramirez, Alfredo (The University of Texas Health Science Center at San Antonio (Estats Units d'Amèrica))
Lambert, Jean-Charles (Institut Pasteur Lille (França))
Dichgans, Martin (Munich Cluster for Systems Neurology (SyNergy))
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1. 6- to 1. 9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer Disease ; Cognitive Dysfunction ; Genome-Wide Association Study ; Humans ; Tau Proteins
Publicat a:	Nature genetics, Vol. 54 Núm. 4 (April 2022) , p. 412-436, ISSN 1546-1718

DOI: 10.1038/s41588-022-01024-z
PMID: 35379992

33 p, 4.9 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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