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Cerca | Lliura | Ajuda | Servei de Biblioteques | Sobre el DDD | Català English Español |
Pàgina inicial > Articles > Articles publicats > Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease |
Data: | 2022 |
Resum: | Background: Adults with Down syndrome are at an ultra-high risk of developing early-onset Alzheimer's disease. Episodic memory deficits are one of the earliest signs of the disease, but their association with regional brain atrophy in the population with Down syndrome has not been explored. We aimed to investigate the neuroanatomical correlates of episodic memory in adults with Down syndrome and symptomatic Alzheimer's disease. Methods: Single-center, cross-sectional study. A total of 139 adults with Down syndrome (85 asymptomatic and 54 with symptomatic Alzheimer's disease) were included in the study (mean age 43. 6 ± 10. 9 years, 46% female). Episodic memory was assessed using the modified Cued Recall Test. Immediate (trial 1 free immediate recall, trial 3 free immediate recall, total free immediate recall score, and total immediate score) and delayed scores (free delayed recall score and total delayed score) were examined. Cortical thickness from magnetic resonance imaging was determined with surface-based morphometry using the FreeSurfer 6. 0 software package. The clusters of reduced cortical thickness were compared between symptomatic and asymptomatic participants to create a cortical atrophy map. Then, the correlation between cortical thickness and the modified Cued Recall Test subscores were separately assessed in symptomatic and asymptomatic subjects, controlling for age, sex, and severity of intellectual disability. Results: Compared with asymptomatic participants, those with symptomatic Alzheimer's disease showed a pattern of cortical atrophy in posterior parieto-temporo-occipital cortices. In symptomatic subjects, trial 1 immediate free recall significantly correlated with cortical atrophy in lateral prefrontal regions. Trial 3 free immediate recall and total free immediate recall were associated with the most widespread cortical atrophy. Total immediate score was related to posterior cortical atrophy, including lateral parietal and temporal cortex, posterior cingulate cortex, precuneus, and medial temporal lobe areas. Delayed memory scores were associated with cortical atrophy in temporoparietal and medial temporal lobe regions. No significant relationships were observed between episodic memory measures and cortical atrophy in asymptomatic subjects. Conclusions: Different episodic memory measures were associated with cortical atrophy in specific brain regions in adults with Down syndrome and Alzheimer's disease. These results overlap with those described in sporadic Alzheimer's disease and further support the similarities between Down syndrome-associated Alzheimer's disease and that in the general population. |
Ajuts: | Instituto de Salud Carlos III PI17/01019 Instituto de Salud Carlos III PI20/01473 Instituto de Salud Carlos III PI13/01532 Instituto de Salud Carlos III PI14/01126 Instituto de Salud Carlos III PI16/01825 Instituto de Salud Carlos III INT19/00016 Instituto de Salud Carlos III PI18/00435 Instituto de Salud Carlos III PI14/1561 Instituto de Salud Carlos III PI17/01896 Instituto de Salud Carlos III PI18/00335 Instituto de Salud Carlos III CP20/00038 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT006/17/00119 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT002/16/00408 Agència de Gestió d'Ajuts Universitaris i de Recerca SLT006/17/00125 |
Nota: | Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); National Institutes of Health (NIA grants 1R01AG056850-01A1, R21AG056974, R01AG061566); Fundació La Marató de TV3 (20141210, 044412); Fundació Catalana Síndrome de Down; Fundació Víctor Grífols i Lucas; Fundació Bancaria La Caixa; Jérôme Lejeune Foundation. |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Down syndrome ; Alzheimer's disease ; Dementia ; Episodic memory ; MRI ; Cortical thickness |
Publicat a: | Alzheimer's research & therapy, Vol. 14 Núm. 1 (december 2022) , p. 123, ISSN 1758-9193 |
10 p, 1.5 MB |