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Pàgina inicial > Articles > Articles publicats > Synthesis of novel nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold |
Data: | 2015 |
Resum: | A new class of carbocyclic nucleoside analogues built on a bicyclo[4. 1. 0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein-ligand docking studies. The asymmetric synthesis of a series of these compounds incorporating different nucleobases has been efficiently completed starting from 1,4-cyclohexanedione. |
Ajuts: | Ministerio de Economía y Competitividad CTQ2014-54071 Ministerio de Economía y Competitividad CTQ2013-41161-R |
Nota: | Altres ajuts: we acknowledge a grant from the Generalitatde Catalunya (to B.D.-P.) |
Drets: | Tots els drets reservats. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió acceptada per publicar |
Matèria: | Alcohols ; Antimicrobial agents ; Hydrocarbons ; Nucleic acids ; Peptides and proteins |
Publicat a: | Journal of organic chemistry, Vol. 80, issue 19 (Oct. 2015) , p. 9495-9505, ISSN 1520-6904 |
Postprint 33 p, 1004.1 KB |