| Título variante: |
Function of Biomolecules in Health and Illness |
| Título variante: |
Función de Biomoléculas en Salud y Enfermedad |
| Fecha: |
2023-24 |
| Resumen: |
1 En finalitzar el mòdul, l'estudiant serà capaç de: 1) Planificar experiments d'identificació, expressió, purificació i caracterització funcional de biomolècules. 2) Analitzar l'estructura i la funció de proteïnes amb tècniques bioinformàtiques. 3) Relacionar canvis estructurals i funcionals de biomolècules amb patologies. 4) Seleccionar i aplicar les metodologies per al disseny d'inhibidors enzimàtics. 5) Identificar i caracteritzar inhibidors enzimàtics com a fàrmacs. 6) Utilitzar la tecnologia enzimàtica per a les aplicacions biomèdiques i biotecnològiques. 7) Reconèixer biomolècules associades a patologies humanes i utilitzar-les com a dianes terapèutiques. 8) Relacionar determinades malalties amb l'acumulació de proteïnes mal plegades. 9) Conèixer la base molecular de malalties degudes a mutacions dinàmiques i a canvis epigenètics. 10) Valorar el paper funcional dels lípids de membrana i la seva participació en determinades patologies. 11) Conèixer les principals tècniques i instal·lacions d'un laboratori de bioquímica clínica de referència. |
| Resumen: |
Upon completion of the module, the student will be able to: 1 Upon completion of the module, the student will be able to: 1. Plan experiments for the identification, expression, purification, and functional characterization of biomolecules. 2. Analyze the structure and function of proteins using bioinformatics techniques. 3. Relate structural and functional changes in biomolecules to pathologies. 4. Select and apply methodologies for the design of enzyme inhibitors. 5. Identify and characterize enzyme inhibitors as drugs. 6. Utilize enzymatic technology for biomedical and biotechnological applications. 7. Recognize biomolecules associated with human pathologies and use them as therapeutic targets. 8. Associate specific diseases with the accumulation of misfolded proteins. 9. Understand the molecular basis of diseases caused by dynamic mutations and epigenetic changes. 10. Assess the functional role of membrane lipids and their involvement in specific pathologies. 11. Familiarize themselves with the main techniques and facilities in a reference clinical biochemistry laboratory. Competencies Advanced Biotechnology Apply techniques for modifying living organisms or parts thereof to improve pharmaceutical and biotechnological processes and products, or to develop new products. (Specialization in Molecular and Therapeutic Biotechnology) Ability to synthesize, analyze alternatives, and engage in critical debate. Integrate the content of metabolic pathways in living organisms under normal, pathological, or exogenously modified conditions (Specialization in Molecular and Therapeutic Biotechnology). Apply acquired knowledge and problem-solving skills in new or unfamiliar environments within broader (or multidisciplinary) contexts related to their field of study. Effectively communicate their conclusions, as well as the knowledge and ultimate reasons underlying them, to specialized and non-specialized audiences in a clear and unambiguous manner. Possess learning skills that enable them to continue studying, largely through self-directed and autonomous work. Possess knowledge that provides the foundation or opportunity for originality in the development or application of ideas, often in a research context. Utilize and responsibly manage bibliographic information and computer resources related to biotechnology. Biochemistry, Molecular Biology, and Biomedicine Analyze research results to obtain new biotechnological or biomedical products and transfer them to society. Analyze and accurately interpret the molecular mechanisms operating in living organisms and identify their applications. Apply techniques for modifying living organisms or parts thereof to improve pharmaceutical and biotechnological processes and products, or to develop new products. 2 Develop critical reasoning within the field of study and in relation to the scientific or business environment. Identify and utilize bioinformatic tools to solve problems related to biochemistry, molecular biology, and biomedicine. Integrate content in biochemistry, molecular biology, biotechnology, and biomedicine from a molecular perspective. Apply acquired knowledge and problem-solving skills in new or unfamiliar environments within broader (or multidisciplinary) contexts related to their field of study. Effectively communicate their conclusions, as well as the knowledge and ultimate reasons underlying them, to specialized and non-specialized audiences in a clear and unambiguous manner. Possess learning skills that enable them to continue studying, largely through self-directed and autonomous work. Possess knowledge that provides the foundation or opportunity for originality in the development or application of ideas, often in a research context. Utilize and manage bibliographic information and computer resources related to biochemistry, molecular biology, or biomedicine. Utilize scientific terminology to argue research results and effectively communicate them orally and in writing. |
| Resumen: |
Al finalizar el módulo, el estudiante será capaz de: 1 Al finalizar el módulo, el estudiante será capaz de: 1. Planificar experimentos de identificación, expresión, purificación y caracterización funcional de biomoléculas. 2. Analizar la estructura y función de proteínas mediante técnicas bioinformáticas. 3. Relacionar cambios estructurales y funcionales de biomoléculas con patologías. 4. Seleccionar y aplicar metodologías para el diseño de inhibidores enzimáticos. 5. Identificar y caracterizar inhibidores enzimáticos como fármacos. 6. Utilizar la tecnología enzimática para aplicaciones biomédicas y biotecnológicas. 7. Reconocer biomoléculas asociadas a patologías humanas y utilizarlas como blancos terapéuticos. 8. Relacionar ciertas enfermedades con la acumulación de proteínas mal plegadas. 9. Conocer la base molecular de enfermedades causadas por mutaciones dinámicas y cambios epigenéticos. 10. Valorar el papel funcional de los lípidos de membrana y su participación en ciertas patologías. 11. Conocer las principales técnicas e instalaciones de un laboratorio de bioquímica clínica de referencia. |
| Derechos: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Lengua: |
Català, anglès, castellà |
| Titulación: |
Bioquímica, Biologia Molecular i Biomedicina [4313794] ; Biotecnologia Avançada [4313772] |
| Plan de estudios: |
Màster Universitari en Bioquímica, Biologia Molecular i Biomedicina [1153] ; Màster Universitari en Biotecnologia Avançada [1154] ; Màster Universitari en Biotecnologia Avançada [1561] |
| Documento: |
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