The PRALINE database : protein and Rna humAn singLe nucleotIde variaNts in condEnsates
Vandelli, Andrea (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Arnal, Magdalena (Università degli Studi di Roma "La Sapienza")
Monti, Michele (Istituto Italiano di Tecnologia)
Fiorentino, Jonathan (Istituto Italiano di Tecnologia)
Broglia, Laura (Istituto Italiano di Tecnologia)
Colantoni, Alessio (Università degli Studi di Roma "La Sapienza")
Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Armaos, Alexandros (Istituto Italiano di Tecnologia)
Tartaglia, Gian Gaetano (Istituto Italiano di Tecnologia)

Date:	2023
Abstract:	Biological condensates are membraneless organelles with different material properties. Proteins and RNAs are the main components, but most of their interactions are still unknown. Here, we introduce PRALINE, a database for the interrogation of proteins and RNAs contained in stress granules, processing bodies and other assemblies including droplets and amyloids. PRALINE provides information about the predicted and experimentally validated protein-protein, protein-RNA and RNA-RNA interactions. For proteins, it reports the liquid-liquid phase separation and liquid-solid phase separation propensities. For RNAs, it provides information on predicted secondary structure content. PRALINE shows detailed information on human single-nucleotide variants, their clinical significance and presence in protein and RNA binding sites, and how they can affect condensates' physical properties. PRALINE is freely accessible on the web at .
Grants:	European Commission 727658 European Commission 855923 European Commission 825080
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Bioinformatics, Vol. 39, Num.1 (January 2023) , art. btac847, ISSN 1367-4811

DOI: 10.1093/bioinformatics/btac847
PMID: 36592044

3 p, 1.6 MB

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