Epigenetic therapies for neuroblastoma : immunogenicity awakens
Jiménez Jiménez, Carlos (Human Technopole)
Moreno, Lucas (Hospital Universitari Vall d'Hebron)
Segura, Miguel F. (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	The development of immunotherapies for neuroblastoma remains challenging owing to the low immunogenicity of neuroblastoma cells, as reflected by the low expression of one of the main triggers of immune recognition, the major histocompatibility complex class I (MHC-I). Cornel et al. showed that epigenetic modulation of neuroblastoma cells with a histone deacetylase inhibitor can boost the expression of major histocompatibility complex class I, among other immune receptors, priming their recognition by T- and natural killer cells. By leveraging the developmentally related aberrant epigenetic landscapes of neuroblastoma, these discoveries pave the way to overcome a major limitation in the field of neuroblastoma immunotherapy. Immunotherapies against the aggressive childhood tumour neuroblastoma remain challenged due to its low capacity of response to the immune system action. A recent work shows that that its immune responsiveness can be restored with entinostat, a molecule that promotes an epigenetic modulation that boosts the expression of immunogenic receptors, sensitising neuroblastoma cells to immunotherapy.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Histone deacetylase inhibitors ; Immunotherapy ; Major histocompatibility complex class I ; Neuroblastoma
Published in:	Molecular oncology, Vol. 17 (march 2023) , p. 718-721, ISSN 1878-0261

DOI: 10.1002/1878-0261.13404
PMID: 36840349

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