Characterization of a proteomic profile associated with organ dysfunction and mortality of sepsis and septic shock
Ruiz-Sanmartín, Adolfo (Hospital Universitari Vall d'Hebron)
Ribas Ripoll, Vicent (Centre Tecnològic de Catalunya)
Suñol, David (Centre Tecnològic de Catalunya)
Chiscano-Camón, Luis (Hospital Universitari Vall d'Hebron)
Palmada, Clara (Hospital Universitari Vall d'Hebron)
Bajaña, Iván (Hospital Universitari Vall d'Hebron)
Larrosa, María Nieves (Hospital Universitari Vall d'Hebron)
González-López, Juanjo 1975- (Hospital Universitari Vall d'Hebron)
Canela, Núria (Centre Tecnològic de Catalunya)
Ferrer, Ricard (Hospital Universitari Vall d'Hebron)
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	The search for new biomarkers that allow an early diagnosis in sepsis and predict its evolution has become a necessity in medicine. The objective of this study is to identify, through omics techniques, potential protein biomarkers that are expressed in patients with sepsis and their relationship with organ dysfunction and mortality. Prospective, observational and single-center study that included adult patients (≥ 18 years) who were admitted to a tertiary hospital and who met the criteria for sepsis. A mass spectrometry-based approach was used to analyze the plasma proteins in the enrolled subjects. Subsequently, using recursive feature elimination classification and cross-validation with a vector classifier, an association of these proteins with mortality and organ dysfunction was established. The protein-protein interaction network was analyzed with String software. 141 patients were enrolled in this study. Mass spectrometry identified 177 proteins. Of all of them, and by recursive feature elimination, nine proteins (GPX3, APOB, ORM1, SERPINF1, LYZ, C8A, CD14, APOC3 and C1QC) were associated with organ dysfunction (SOFA.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 17 (december 2022) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0278708
PMID: 36459524

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