IgG anti-high density lipoprotein antibodies are elevated in abdominal aortic aneurysm and associated with lipid profile and clinical features
Rodríguez-Carrio, Javier (Instituto de Investigación Sanitaria del Principado de Asturias)
Lindholt, Jes S. (Odense University Hospital (Dinamarca))
Canyelles, Marina (Institut d'Investigació Biomèdica Sant Pau)
Martínez-López, Diego (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Tondo, Mireia (Institut d'Investigació Biomèdica Sant Pau)
Blanco-Colio, Luis Miguel (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Michel, Jean-Baptiste (Hospital Bichat Claude Bernard)
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau)
Suárez, Ana (Instituto de Investigación Sanitaria del Principado de Asturias)
Martín-Ventura, José Luis (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	High-density lipoproteins cholesterol (HDLc) levels are decreased in abdominal aortic aneurysm (AAA), which is hallmarked by autoimmunity and lipid aortic deposits. To investigate whether IgG anti-HDL antibodies were present in AAA and their potential association with clinical features, IgG anti-HDL and total IgG along with HDLc plasma levels were measured in 488 AAA patients and 184 controls from the Viborg Vascular (VIVA) study, and in tissue-conditioned media from AAA intraluminal thrombus and media layer samples compared to control aortas. Higher IgG anti-HDL levels were found in AAA compared to controls, even after correcting for total IgG, and after adjusting for potential confounders. IgG anti-HDL levels were correlated with aortic diameter in univariate and adjusted multivariate analyses. IgG anti-HDL antibodies were negatively associated with HDLc levels before and after correcting for potential confounders. Increased anti-HDL antibodies were identified in tissue-conditioned media from AAA samples compared to healthy aortas, with higher levels being observed in the media layer. In conclusion, increased IgG anti-HDL levels (both in plasma and in tissue) are linked to AAA, associated with aortic diameter and HDLc levels. These data suggest a potential immune response against HDL in AAA and support an emerging role of anti-HDL antibodies in AAA.
Ajuts:	Ministerio de Economía y Competitividad PI16/00113 Ministerio de Economía y Competitividad FJCI-2015-23849
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Abdominal aortic aneurysm ; Autoantibodies ; Autoimmunity ; HDLc
Publicat a:	Journal of clinical medicine, Vol. 9 Núm. 1 (january 2020) , p. 67, ISSN 2077-0383

DOI: 10.3390/jcm9010067
PMID: 31888089

12 p, 506.2 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats