Phages in the human body
Navarro Risueño, Ferran (Institut d'Investigació Biomèdica Sant Pau)
Muniesa, Maite (Universitat de Barcelona. Departament de Microbiologia)

Data:	2017
Resum:	Bacteriophages, viruses that infect bacteria, have re-emerged as powerful regulators of bacterial populations in natural ecosystems. Phages invade the human body, just as they do other natural environments, to such an extent that they are the most numerous group in the human virome. This was only revealed in recent metagenomic studies, despite the fact that the presence of phages in the human body was reported decades ago. The influence of the presence of phages in humans has yet to be evaluated; but as in marine environments, a clear role in the regulation of bacterial populations could be envisaged, that might have an impact on human health. Moreover, phages are excellent vehicles of genetic transfer, and they contribute to the evolution of bacterial cells in the human body by spreading and acquiring DNA horizontally. The abundance of phages in the human body does not pass unnoticed and the immune system reacts to them, although it is not clear to what extent. Finally, the presence of phages in human samples, which most of the time is not considered, can influence and bias microbiological and molecular results; and, in view of the evidences, some studies suggest that more attention needs to be paid to their interference.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-1043 Ministerio de Economía y Competitividad PI16/00158 Ministerio de Economía y Competitividad AGL2016-75536-P
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Bacteriophages ; Diagnosis ; Homeostasis ; Human biomes ; Metagenomics ; Virome
Publicat a:	Frontiers in microbiology, Vol. 8 Núm (April 2017) , art. 566, ISSN 1664-302X

DOI: 10.3389/fmicb.2017.00566
PMID: 28421059

7 p, 2.1 MB

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