Web of Science: 6 cites, Scopus: 7 cites, Google Scholar: cites,
New Pieces for an Old Puzzle : Approaching Parkinson's Disease from Translatable Animal Models, Gut Microbiota Modulation, and Lipidomics
Ortega Moreno, Lorena (University Rey Juan Carlos)
Bagues, Ana (University Rey Juan Carlos)
Martínez Perea, Vicente (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Abalo, Raquel (University Rey Juan Carlos)
Universitat Autònoma de Barcelona. Institut de Neurociències

Data: 2023
Resum: Parkinson's disease (PD) is a severe neurodegenerative disease characterized by disabling motor alterations that are diagnosed at a relatively late stage in its development, and non-motor symptoms, including those affecting the gastrointestinal tract (mainly constipation), which start much earlier than the motor symptoms. Remarkably, current treatments only reduce motor symptoms, not without important drawbacks (relatively low efficiency and impactful side effects). Thus, new approaches are needed to halt PD progression and, possibly, to prevent its development, including new therapeutic strategies that target PD etiopathogeny and new biomarkers. Our aim was to review some of these new approaches. Although PD is complex and heterogeneous, compelling evidence suggests it might have a gastrointestinal origin, at least in a significant number of patients, and findings in recently developed animal models strongly support this hypothesis. Furthermore, the modulation of the gut microbiome, mainly through probiotics, is being tested to improve motor and non-motor symptoms and even to prevent PD. Finally, lipidomics has emerged as a useful tool to identify lipid biomarkers that may help analyze PD progression and treatment efficacy in a personalized manner, although, as of today, it has only scarcely been applied to monitor gut motility, dysbiosis, and probiotic effects in PD. Altogether, these new pieces should be helpful in solving the old puzzle of PD.
Ajuts: Agencia Estatal de Investigación PID2019-111510RB-I00
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Animal models ; Constipation ; Dopamine ; Gastrointestinal ; Gut-brain axis ; Lipidome ; Microbiota ; Non-motor symptoms ; Parkinson's disease ; Probiotics
Publicat a: Nutrients, Vol. 15, Num. 12 (June 2023) , art. 2775, ISSN 2072-6643

DOI: 10.3390/nu15122775
PMID: 37375679


36 p, 1.1 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Neurociències (INc)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2024-01-17, darrera modificació el 2024-05-05



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