Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia : A Study on Behalf of Eurocord and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Ruggeri, Annalisa (San Raffaele Scientific Institute (Milà, Itàlia))
Galimard, Jacques-Emmanuel (Hôpital Saint-Antoine (Paris, França))
Labopin, Myriam (Hôpital Saint-Antoine (Paris, França))
Rafii El Ayoubi, Hanadi (Eurocord. Hôpital Saint Louis and IUH University Paris VII (França))
Blaise, Didier (Institut Paoli Calmettes (França))
Ciceri, Fabio (San Raffaele Scientific Institute (Milà, Itàlia))
Díez-Martín, José Luis (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Cornelissen, Jan (Erasmus MC Cancer Institute. University Medical Centre (Països Baixos))
Chevallier, Patrice (Hematology Service. Hôtel Dieu (França))
Sanchez-Guijo, Fermin (Hospital Universitario de Salamanca)
Nicholson, Emma (Royal Marsden Hospital (Regne Unit))
Castagna, Luca (Humanitas Cancer Center (Itàlia))
Forcade, Edouard (CHU Bordeaux. Hôpital Haut-leveque (França))
Kuball, Jürgen (Department of Hematology. University Medical Centre (Països Baixos))
Rovira Argelagués, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Koc, Yener (Medicana International (Turquia))
Pavlu, Jiri (Hammersmith Hospital. Imperial College (Regne Unit))
Gulbas, Zafar (Anadolu Medical Center Hospital (Turquia))
Vydra, Jan (Institute of Hematology and Blood Transfusion)
Baron, Frederic (Université de Liège)
Sanz, Jaime (Hospital Universitari i Politècnic La Fe (València))
Spyridonidis, Alexandros (University Hospital of Patras (Grècia))
Savani, Bipin (Vanderbilt University Medical Center (Turquia))
Gluckman, Eliane (Monacord. Centre Scientifique de Monaco)
Nagler, Arnon (Tel Aviv University. Chaim Sheba Medical Center)
Mohty, Mohamad (Sorbonne Université)

Data:	2022
Resum:	Unmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with high-risk acute myelogenous leukemia (AML). This study compared outcomes after dUCBT and haplo-HCT using peripheral blood stem cells (PBSCs) in adult patients with AML in complete remission (CR) who underwent transplantation in European Society for Blood and Marrow Transplantation (EBMT)-affiliated centers. In a population of adults with de novo AML in first or second CR, we compared outcomes after dUCBT (n = 165) and after haplo-PTCY PBSC (n = 544) performed between January 2013 and December 2018. Patients receiving in vivo antithymocyte globulin, Campath, or ex vivo T cell depletion were excluded. The median follow-up was 33 months for the haplo-PTCY arm and 52 months for the dUCBT arm. No statistically significant differences were observed between the 2 arms in the rates of grade II-IV acute graft-versus-host disease (GVHD) (hazard ratio [HR], 1. 31; P =. 18), grade III-IV acute GVHD (HR, 1. 17; P =. 56), chronic GVHD (HR,. 86; P =. 48), relapse (HR, 1. 07; P =. 77), nonrelapse mortality (NRM) (HR,. 94; P =. 77), leukemia-free survival (LFS) (HR,. 99; P =. 95), or overall survival (OS) (HR,. 99; P =. 97). Favorable cytogenetic risk was the sole factor predictive of lower relapse incidence (RI). Younger age at transplantation was associated with lower NRM and higher LFS and OS. Both dUCBT and haplo-PTCY with PBSCs can be considered valid approaches for adult AML patients in CR. New strategies should be investigated in both settings to define the most appropriate conditioning regimen and potentially decrease RI and NRM through better immune reconstitution and optimal supportive care.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Acute myelogenous leukemia ; Haploidentical transplant ; Double cord blood transplantation ; Post-transplantation cyclophosphamide
Publicat a:	Transplantation and cellular therapy, Vol. 28 Núm. 10 (october 2022) , p. 710.e1-710.e10, ISSN 2666-6367

DOI: 10.1016/j.jtct.2022.07.006

10 p, 732.1 KB

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