A saturated map of common genetic variants associated with human height
Yengo, Loic (The University of Queensland (Queensland, Austràlia))
Vedantam, Sailaja (Program in Medical and Population Genetics. Broad Institute of MIT and Harvard (Cambridge, Estats Units d'Amèrica))
Marouli, Eirini (William Harvey Research Institute. Barts and the London School of Medicine and Dentistry. Queen Mary University of London (Londres, Regne unit))
Sidorenko, Julia (Institute for Molecular Bioscience. The University of Queensland (Queensland, Austràlia))
Bartell, Eric (Harvard Medical School)
Sakaue, Saori (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Graff, Marielisa (Gillings School of Global Public Health. University of North Carolina at Chapel Hill (Chapel Hill, Estats Units d'Amèrica))
Eliasen, Anders U. (Section for Bioinformatics. Department of Health Technology. Technical University of Denmark (Copenhaguen, Dinamarca))
Jiang, Yunxuan (23andMe (California, Estats Units d'Amèrica))
Raghavan, Sridharan (Division of Biomedical Informatics and Personalized Medicine. University of Colorado Anschutz Medical Campus (Aurora, Estats Units d'Amèrica))
Miao, Jenkai (Broad Institute of MIT and Harvard (Cambridge, Estats Units d'Amèrica))
Arias, Joshua D. (National Cancer Institute (Rockville, Estats Units d'Amèrica))
Graham, Sarah E. (University of Michigan (Michigan, Estats Units d'Amèrica))
Mukamel, Ronen E. (Harvard Medical School)
Spracklen, Cassandra N. (University of Massachusetts (Massachusetts, Estats Units d'Amèrica))
Yin, Xianyong (University of Michigan School of Public Health (Ann Arbor,Estats Units d'Amèrica))
Chen, Shyh-Huei (Wake Forest School of Medicine (Winston-Salem, Estats Units d'Amèrica))
Ferreira, Teresa (University of Oxford (Oxford, Regne Unit))
Highland, Heather H. (University of North Carolina at Chapel Hill (Chapel Hill, Estats Units d'Amèrica))
Ji, Yingjie (University of Exeter (Exter, Regne Unit))
Karaderi, Tugce (University of Oxford (Oxford, Regne Unit))
Lin, Kuang (Nuffield University of Oxford (Oxford, Regne Unit))
Lüll, Kreete (University of Tartu (Tartu, Estònia))
Malden, Deborah (University of Oxford (Oxford, Regne Unit))
Medina-Gomez, Carolina (University Medical Center Rotterdam (Rotterdam, Països Baixos))
Machado, Moara (National Cancer Institute (Rockville, Estats Units d'Amèrica))
Moore, Amy (RTI International (Durham, Estats Units d'Amèrica))
Rüeger, Sina (Swiss Institute of Bioinformatics (Lausanne, Suïssa))
Sim, Xueling (National University of Singapore (Singapur))
Vrieze, Scott (University of Minnesota (Minnesota, Estats Units d'Amèrica))
Ahluwalia, Tarunveer Singh (University of Copenhagen (Copenhaguen, Dinamarca))
Akiyama, Masato (Kyushu University (Fukuoka, Japó))
Allison, Matthew A. (University of California (San Diego, Estats Units d'Amèrica))
Álvarez, Marcus (David Geffen School of Medicine at UCLA (Los Angeles, Estats Units d'Amèrica))
Andersen, Mette korre (University of Copenhagen (Copenhaguen, Dinamarca))
Ani, Alireza (Isfahan University of Medical Sciences (Isfahan, Iran))
Appadurai, Vivek (Copenhagen University Hospital (Copenhaguen, Dinamarca))
Arbeeva, Liubov (University of North Carolina at Chapel Hill (Chapel Hill, Estats Units d'Amèrica))
Bhaskar, Seema (CSIR-Centre for Cellular and Molecular Biology)
Bielak, Lawrence F. (University of Michigan School of Public Health)
Bollepalli, Sailalitha (University of Helsinki)
Bonnycastle, Lori L. (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Bork-Jensen, Jette (University of Copenhagen (Copenhaguen, Dinamarca))
Bradfield, Jonathan Paul (Quantinuum Research (Wayne, Estats Units d'Amèrica))
Bradford, Yuki (University of Pennsylvania (Filadèlfia, Estats Units d'Amèrica))
Braund, Peter S. (Glenfield Hospital (Leicester, Regne Unit))
Brody, Jennifer A. (University of Washington (Washington, Estats Units d'Amèrica))
Burgdorf, Kristoffer S. (Copenhagen University (Copenhaguen, Dinamarca))
Cade, Brian E. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Cai, H. (Vanderbilt University Medical Center)
Cai, Qiuyin (Vanderbilt University Medical Center)
Campbell, Archie (University of Edinburgh)
Cañadas-Garre, Marisa (Queen's University of Belfast)
Catamo, Eulalia (Burlo Garofolo)
Chai, Jin-Fang (National University of Singapore and National University Health System (Singapore))
Chai, Xiaoran (National University of Singapore and National University Health System)
Chang, Liching (Academia Sinica (Taiwan))
Chang, Yicheng (National Taiwan University Hospital)
Chen, Chien Hsiun (Academia Sinica (Taiwan))
Chesi, Alessandra (Children's Hospital of Philadelphia (Pennsilvània))
Choi, Seunghoan (Broad Institute of MIT and Harvard)
Chung, Renhua (National Health Research Institutes)
Cocca, Massimiliano (Burlo Garofolo)
Concas, Maria Pina (Burlo Garofolo)
Couture, Christian Y. (Université Laval)
Cuellar-Partida, Gabriel (University of Queensland Diamantina Institute)
Danning, Rebecca D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Daw, E. Warwick (Washington University School of Medicine)
Degenhard, Frauke (Christian-Albrechts University of Kiel)
Delgado, Graciela E. (Heidelberg University)
Delitala, Alessandro (Università degli Studi di Sassari)
Demirkan, Ayşe (University of Surrey)
Deng, Xuan (Boston University School of Public Health)
Devineni, Poornima (Veterans Affairs Boston Healthcare System)
Dietl, Alexander (University Hospital Regensburg)
Dimitriou, Maria E. (Harokopio University of Athens)
Dimitrov, Latchezar M. (Medical Center Boulevard)
Dorajoo, Rajkumar (Duke-NUS Medical School)
Ekici, Arif B. (Friedrich-Alexander-Universität Erlangen-Nürnberg)
Engmann, Jorgen (University College London)
Fairhurst-Hunter, Zammy (University of Oxford (Oxford, Regne Unit))
Farmaki, Aliki Eleni (Harokopio University of Athens)
Faul, Jessica D. (University of Michigan)
Fernandez-Lopez, Juan Carlos (National Institute of Genomic Medicine)
Forer, Lukas (Medical University of Innsbruck)
Francescatto, Margherita (University of Trieste)
Freitag-Wolf, Sandra (Kiel University)
Fuchsberger, Christian (Affiliated Institute of the University of Lübeck)
Galesloot, Tessel E. (Radboud University Medical Center)
Gao, Yan (University of Mississippi)
Gao, Zishan (Helmholtz Zentrum München Research Center for Environmental Health)
Geller, Frank (Statens Serum Institut)
Giannakopoulou, Olga (Queen Mary University of London (Londres, Regne Unit))
Giulianini, Franco (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Gjesing, Anette Prior (University of Copenhagen (Copenhaguen, Dinamarca))
Goel, Anuj (University of Oxford (Oxford, Regne Unit))
Gordon, Scott D. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Gorski, Mathias M. (University of Regensburg)
Grove, Jakob (Aarhus University)
Guo, Xiuqing (Harbor-UCLA Medical Center)
Gustafsson, S. (Uppsala University)
Haessler, Jeffrey W. (Fred Hutchinson Cancer Research Center)
Hansen, Thomas Folkmann (Copenhagen University Hospital (Copenhaguen, Dinamarca))
Havulinna, Aki Samuli (Finnish Institute for Health and Welfare)
Haworth, S.J. (University of Bristol)
He, Jing (Vanderbilt University Medical Center)
Heard-Costa, Nancy L. (Framingham Heart Study)
Hebbar, Prashantha (Dasman Diabetes Institute)
Hindy, George (Lund University)
Ho, Yuk Lam Anne (Veterans Affairs Boston Healthcare System)
Hofer, Edith (Medical University of Graz)
Holliday, Elizabeth (University of Newcastle)
Horn, Katrin (University of Leipzig)
Hornsby, Whitney E. (University of Michigan (Michigan, Estats Units d'Amèrica))
Hottenga, Jouke Jan (Vrije Universiteit Amsterdam)
Huang, Hongyan (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica))
Huang, Jie (Peking University)
Huerta-Chagoya, Alicia (Instituto Nacional de Ciencias Médicas y Nutrición)
Huffman, Jennifer E. (Veterans Affairs Boston Healthcare System)
Hung, Yijen (Tri-Service General Hospital Songshan Branch)
Huo, Shaofeng (Chinese Academy of Sciences)
Hwang, Mi-yeong (National Institute of Health)
Iha, Hiroyuki (Otsuka Pharmaceutical Co.)
Ikeda, Daisuke D. (Otsuka Pharmaceutical Co.)
Isono, Masato (National Center for Global Health and Medicine)
Jackson, Anne U. (University of Michigan School of Public Health (Ann Arbor,Estats Units d'Amèrica))
Jäger, Susanne (German Center for Diabetes Research (DZD))
Jansen, Iris E. (Vrije Universiteit Medical Center)
Johansson, Ingegerd (Umeå University)
Jonas, Jost Bruno (Capital Medical University)
Jonsson, Anna Elisabet (University of Copenhagen (Copenhaguen, Dinamarca))
Jørgensen, Torben J. (University of Copenhagen (Copenhaguen, Dinamarca))
Kalafati, IP. (Harokopio University of Athens)
Kanai, Masahiro (Osaka University Graduate School of Medicine (Osaka, Japó))
Kanoni, Stavroula (Queen Mary University of London (Londres, Regne Unit))
Kårhus, Line Lund (Copenhagen University Hospital)
Kasturiratne, Anuradhani (University of Kelaniya)
Katsuya, Tomohiro (Osaka University Graduate School of Medicine)
Kawaguchi, Takahisa (Kyoto University Graduate School of Medicine)
Kember, Rachel L. (University of Pennsylvania)
Kentistou, Katherine A. (University of Edinburgh)
Kim, Hanna (Sungkyunkwan University)
Kim, Young-jin (National Institute of Health)
Kleber, Marcus Edi (SYNLAB MVZ Humangenetik Mannheim)
Knol, Maria J. (University Medical Center Rotterdam)
Kurbasic, Azra (Lund University)
Lauzon, Marie (Harbor-UCLA Medical Center)
Le, Phuong (University of Toronto at Mississauga)
Lea, Rodney A. (Queensland University of Technology)
Lee, Jongyoung (Soonchunhyang Mirai Medical Center)
Leonard, Hampton L. (Data Tecnica International)
Li, Shengchao Alfred (Leidos Biomedical Research)
Li, Xiaoyin (St Cloud State University)
Liang, Jingjing (Case Western Reserve University)
Lin, Honghuang (University of Massachusetts Chan Medical School)
Lin, Shihyi (Taichung Veterans General Hospital)
Liu, Jun (Genome Institute of Singapore)
Liu, Xueping (Statens Serum Institut)
Lo, Ken Sin (Montreal Heart Institute)
Long, Jirong (Vanderbilt University Medical Center)
Lores-Motta, Laura (Radboud University Nijmegen Medical Center)
Luan, Jian'fan N. An (University of Cambridge School of Clinical Medicine)
Lyssenko, Valeriya (Lund University Diabetes Centre)
Lyytikäinen, Leo Pekka (Tampere University Hospital)
Mahajan, Anubha (RIKEN Center for Integrative Medical Sciences)
Mamakou, Vasiliki (National and Kapodistrian University of Athens)
Mangino, Massimo (Guy's and St Thomas' Foundation Trust)
Manichaikul, Ani W. (University of Virginia School of Medicine)
Marten, Jonathan (University of Edinburgh)
Mattheisen, Manuel (University Hospital)
Mavarani, Laven (University Hospital Essen (Alemanya))
McDaid, Aaron F. (Swiss Institute of Bioinformatics (Lausanne, Suïssa))
Meidtner, Karina (German Center for Diabetes Research)
Melendez, Tori L. (University of Michigan (Michigan, Estats Units d'Amèrica))
Mercader, Josep M. (Massachusetts General Hospital (Boston, Estats Units d'Amèrica))
Milaneschi, Yuri (Amsterdam UMC and Vrije Universiteit)
Miller, Jason E. (University of Pennsylvania)
Millwood, Iona Y. (University of Oxford (Oxford, Regne Unit))
Mishra, Pashupati P. (Tampere University)
Mitchell, Ruth E. (University of Bristol)
Møllehave, Line Tang (Copenhagen University Hospital)
Morgan, Anna (Burlo Garofolo)
Mucha, Soeren (University of Lübeck)
Munz, Matthias (University of Lübeck)
Nakatochi, Masahiro (Nagoya University Graduate School of Medicine)
Nelson, Christopher P. (Glenfield Hospital (Leicester, Regne Unit))
Nethander, Maria (University of Gothenburg)
Nho, Chu Won (Gangneung Institute of Natural Products)
Nielsen, Aneta A. (Lillebaelt Hospital)
Nolte, Ilja M. (University Medical Center Groningen (Groningen, Països Baixos))
Nongmaithem, Suraj S. (Wellcome Trust Sanger Institute (Regne Unit))
Noordam, Raymond (Leiden University Medical Center)
Ntalla, Ioanna (Queen Mary University of London (Londres, Regne Unit))
Nutile, Teresa (Institute of Genetics and Biophysics A. Buzzati-Traverso)
Pandit, Anita (University of Michigan School of Public Health (Ann Arbor,Estats Units d'Amèrica))
Christofidou, Paraskevi (King's College London)
Pärna, Katri (University Medical Center Groningen (Groningen, Països Baixos))
Pauper, Marc (Radboud University Nijmegen Medical Center)
Petersen, Eva R.B. (Hospital of Southern Jutland)
Petersen, Liselotte V. (University of Aarhus)
Pitkänen, Niina (University of Turku)
Polašek, Ozren (Algebra University College)
Poveda, Alaitz (Lund University)
Preuss, Michael H. (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Pyarajan, Saiju (Harvard T. H. VA Boston Healthcare System (Boston, Estats Units d'Amèrica))
Raffield, Laura M. (University of North Carolina at Chapel Hill (Chapell Hill, Estats Units d'Amèrica))
Rakugi, Hiromi (Osaka University Graduate School of Medicine)
Ramirez, Julia (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Rasheed, Asif (Center for Non-Communicable Diseases)
Raven, Dennis (University of Groningen)
Rayner, Nigel W. (University of Oxford. Churchill Hospital (Oxford, Regne Unit))
Riveros, Carlos (The University of Newcastle)
Rohde, Rebecca (University of North Carolina at Chapel Hill (Chapel Hill, Estats Units d'Amèrica))
Ruggiero, Daniela (IRCCS Neuromed)
Ruotsalainen, Sanni E. (University of Helsinki)
Ryan, Kathleen A. (University of Maryland School of Medicine)
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau)
Saxena, Richa (Massachusetts General Hospital (Boston, Estats Units d'Amèrica))
Scholz, Markus (University of Leipzig)
Sendamarai, Anoop (Veterans Affairs Boston Healthcare System)
Shen, Botong (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Shi, Jingchunzi (23andMe (California, Estats Units d'Amèrica))
Shin, J.H. (Hallym University)
Sidore, Carlo (Consiglio Nazionale delle Ricerche (CNR))
Sitlani, Collen M. (University of Washington (Washington, Estats Units d'Amèrica))
Slieker, Roderick C. (Amsterdam Cardiovascular Sciences)
Smit, Roelof A. J. (Leiden University Medical Center)
Smith, Albert V. (Icelandic Heart Association)
Smith, Jennifer A. (University of Michigan)
Smyth, Laura J. (Queen's University of Belfast)
Southam, Lorraine (Wellcome Trust Sanger Institute (Regne Unit))
Steinthorsdottir, Valgerdur (deCODE Genetics (Reykjavík, Islàndia))
Sun, Liang (University of Chinese Academy of Sciences)
Takeuchi, Fumihiko (National Center for Global Health and Medicine)
Tallapragada, Divya Sri Priyanka (University of Bergen)
Taylor, Kent (Harbor-UCLA Medical Center)
Tayo, Bamidele O. (Loyola University Chicago)
Tcheandjieu, Catherine (Stanford University School of Medicine)
Terzikhan, Natalie (University Medical Center Rotterdam)
Tesolin, Paola (University of Trieste (Itàlia))
Teumer, Alexander (DZHK (German Centre for Cardiovascular Research))
Theusch, Elizabeth (University of California (Estats Units d'Amèrica))
Thompson, Deborah J. (University of Cambridge (Regne Unit))
Thorleifsson, Gudmar (deCODE Genetics/Amgen (Islàndia))
Timmers, Paul R. H. J. (Western General Hospital (Edimburg, Escòcia))
Trompet, Stella (Leiden University Medical Center)
Turman, Constance (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica))
Vaccargiu, Simona (Consiglio Nazionale delle Ricerche (Itàlia))
van der Laan, Sander W. (Utrecht University (Països Baixos))
van der Most, Peter J. (University Medical Center Groningen (Groningen, Països Baixos))
van Klinken, Jan Bert (University of Amsterdam (Països Baixos))
van Setten, Jessica A. (Utrecht University (Països Baixos))
Verma, Shefali Setia (University of Pennsylvania (Estats Units d'Amèrica))
Verweij, Niek (University Medical Center Groningen (Països Baixos))
Veturi, Yogasudha C. (University of Pennsylvania (Filadèlfia, Estats Units d'Amèrica))
Wang, Carol A. (The University of Newcastle (Austràlia))
Wang, Chaolong (Huazhong University of Science and Technology (Xina))
Wang, Lihua (Washington University School of Medicine (Estats Units d'Amèrica))
Wang, Zhe (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Warren, Helen R. (Queen Mary University of London (Londres, Regne Unit))
Bin Wei, Wen (Capital Medical University (Xina))
Wickremasinghe, Ananda (University of Kelaniya (Sri Lanka))
Wielscher, Matthias (Imperial College London)
Wiggins, Kerri L. (University of Washington (Washington, Estats Units d'Amèrica))
Winsvold, Bendik Slagsvold (Oslo University Hospital (Oslo, Noruega))
Wong, Andrew (University College London (Regne Unit))
Wu, Yang (The University of Queensland (Queensland, Austràlia))
Wuttke, Matthias (University of Freiburg (Alemanya))
Xia, Rui (University of Texas Health Science Center at Houston (Estats Units d'Amèrica))
Xie, Tian (University Medical Center Groningen (Groningen, Països Baixos))
Yamamoto, Ken (Kurume University School of Medicine (Japó))
Yang, Jingyun (Westlake Laboratory of Life Sciences and Biomedicine (Estats Units d'Amèrica))
Yao, Jie (Harbor-UCLA Medical Center (Estats Units d'Amèrica))
Young, Hannah (University of Minnesota (Minnesota, Estats Units d'Amèrica))
Yousri, Noha A. (Alexandria University (Egipte))
Yu, Lei (Rush University Medical Center (Estats Units d'Amèrica))
Zeng, Lingyao (Technical University Munich (Alemanya))
Zhang, Weihua (Imperial College London)
Zhang, Xinyuan (University of Pennsylvania (Filadèlfia, Estats Units d'Amèrica))
Zhao, Jinghua (University of Cambridge (Regne Unit))
Zhao, Wei (University of Michigan School of Public Health (Ann Arbor,Estats Units d'Amèrica))
Zhou, Wei (Broad Institute of MIT and Harvard (Cambridge, Estats Units d'Amèrica))
Zimmermann, Martina E. (University of Regensburg (Alemanya))
Zoledziewska, Magdalena (Consiglio Nazionale delle Ricerche (Itàlia))
Adair, Linda S. (University of North Carolina at Chapel Hill (Estats Units d'Amèrica))
Adams, Hieab H. H. (Universidad Adolfo Ibáñez)
Aguilar-Salinas, Carlos Alberto (Escuela de Medicina y Ciencias de la Salud (Mèxic))
Al-Mulla, Fahd (Dasman Diabetes Institute (Kuwait))
Arnett, Donna (University of Kentucky (Estats Units d'Amèrica))
Asselbergs, Folkert W. (University College London (Regne Unit))
Åsvold, Bjørn Olav (Trondheim University Hospital (Noruega))
Attia, John Richard (University of Newcastle (Austràlia))
Banas, Bernhard (University Hospital Regensburg (Alemanya))
Bandinelli, Stefania (Azienda Toscana Centro (Itàlia))
Bennett, David Alan (Rush University Medical Center (Estats Units d'Amèrica))
Bergler, Tobias (University Hospital Regensburg (Alemanya))
Bharadwaj, Dwaipayan (Jawaharlal Nehru University (Índia))
Biino, Ginevra (National Research Council of Italy (Itàlia))
Bisgaard, Hans (University of Copenhagen (Copenhaguen, Dinamarca))
Boerwinkle, Eric (University of Texas Health Science Center at Houston)
Böger, Carsten A. (KfH Kidney Center Traunstein)
Bønnelykke, Klaus (University of Copenhagen (Copenhaguen, Dinamarca))
Boomsma, Dorret I. (Vrije Universiteit Amsterdam)
Børglum, Anders D. (Aarhus University)
Borja, Judith B. (University of San Carlos)
Bouchard, Claude (Pennington Biomedical Research Center)
Bowden, Donald W. (Medical Center Boulevard)
Brandslund, Ivan (University of Southern Denmark)
Brumpton, Ben (Trondheim University Hospital)
Buring, Julie E. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Caulfield, Mark (Queen Mary University of London (Londres, Regne Unit))
Chambers, John C. (Imperial College London)
Chandak, Giriraj R. (JSS (Deemed to be) University)
Chanock, Stephen (National Cancer Institute (Rockville, Estats Units d'Amèrica))
Chaturvedi, Nish (University College London)
Chen, Yii Der Ida (Harbor-UCLA Medical Center)
Chen, Zhengming (University of Oxford (Oxford, Regne Unit))
Cheng, Ching-Yu (Duke-NUS Medical School)
Christophersen, Ingrid E. (Vestre Viken Hospital Trust)
Ciullo, Marina (IRCCS Neuromed)
Cole, John W. (Baltimore Veterans Affairs Medical Center)
Collins, Francis S. (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Cooper, Richard S. (Loyola University Chicago)
Cruz, Miguel (Instituto Mexicano del Seguro Social)
Cucca, Francesco (Università degli Studi di Sassari)
Cupples, L. Adrienne (Framingham Heart Study)
Cutler, Michael J. (Intermountain Medical Center)
Damrauer, Scott M. (Crescenz VA Medical Center (Filadèlfia, Estats Units d'Amèrica))
Dantoft, Thomas M. (Copenhagen University Hospital - Bispebjerg and Frederiksberg)
de Borst, Gert J. (University of Utrecht)
de Groot, Lisette C.P.G.M. (Department of Human Nutrition. Wageningen University)
De Jager, Philip L. (Columbia University Medical Center)
de Kleijn, D.P.V. (University of Utrecht)
Janaka de Silva, H. (University of Kelaniya)
Dedoussis, George V. (Harokopio University of Athens)
den Hollander, Anneke I. (Radboud University Nijmegen Medical Center)
Du, Shufa (University of North Carolina at Chapel Hill)
Easton, Douglas F. (Department of Oncology. University of Cambridge)
Elders, Petra J. M. (Amsterdam University Medical Center (UMC))
Eliassen, A. Heather Heather (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica))
Ellinor, Patrick T. (Massachusetts General Hospital (Boston, Estats Units d'Amèrica))
Elmståhl, Sölve (Lund University)
Erdmann, Jeanette (University Heart Center Lübeck)
Evans, Michele K. (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Fatkin, Diane (UNSW Sydney)
Feenstra, Bjarke (Statens Serum Institut)
Feitosa, Mary (Washington University School of Medicine)
Ferrucci, Luigi (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Ford, Ian (University of Glasgow)
Fornage, Myriam (University of Texas Health Science Center at Houston)
Franke, Andre (Christian-Albrechts University of Kiel)
Franks, Paul W. (Umeå University)
Freedman, Barry I. (Wake Forest School of Medicine (Winston-Salem, Estats Units d'Amèrica))
Gasparini, Paolo (University of Trieste)
Gieger, Christian (German Center for Diabetes Research)
Girotto, Giorgia (University of Trieste)
Goddard, Michael E. (Precincts and Regions)
Golightly, Yvonne M. (University of North Carolina at Chapel Hill (Chapel Hill, Estats Units d'Amèrica))
Gonzalez-Villalpando, Clicerio (Centro de Estudios en Diabetes)
Gordon-Larsen, P. (University of North Carolina at Chapel Hill)
Grallert, H. (German Center for Diabetes Research)
Grant, Struan F. A. (Children's Hospital of Philadelphia (Pennsilvània))
Grarup, Niels (University of Copenhagen (Copenhaguen, Dinamarca))
Griffiths, L. (Queensland University of Technology)
Gudnason, V. (University of Iceland)
Haiman, C. (Keck School of Medicine of USC)
Hakonarson, Hakon (Children's Hospital of Philadelphia (Pennsilvània))
Hansen, Torben (University of Copenhagen (Copenhaguen, Dinamarca))
Hartman, C.A. (University Medical Center Groningen)
Hattersley, A.T. (University of Exeter Medical School)
Hayward, Caroline (University of Edinburgh)
Heckbert, S.R. (University of Washington)
Heng, C.K. (National University Health System)
Hengstenberg, C. (Medical University of Vienna)
Hewitt, Alex W. (University of Western Australia)
Hishigaki, H. (Otsuka Pharmaceutical Co.)
Hoyng, C.B. (Radboud University Nijmegen Medical Center)
Huang, Paul L. (Massachusetts General Hospital (Boston, Estats Units d'Amèrica))
Huang, W. (Shanghai Industrial Technology Institute)
Hunt, S.C. (University of Utah)
Hveem, K. (Norwegian University of Science and Technology)
Hyppönen, E. (South Australian Health and Medical Research Institute)
Iacono, William (University of Minnesota (Minnesota, Estats Units d'Amèrica))
Ichihara, S. (Jichi Medical University School of Medicine)
Ikram, M.A. (University Medical Center Rotterdam)
Isasi, C.R. (Albert Einstein College of Medicine (Nova York, Estats Units d'Amèrica))
Jackson, R.D. (Ohio State University)
Jarvelin, Marjo-Riitta (Brunel University London)
Jin, Zi-Bing (Wenzhou Medical University)
Jöckel, K.H. (University Hospital Essen (Alemanya))
Joshi, P.K. (University of Edinburgh)
Jousilahti, P. (Finnish Institute for Health and Welfare)
Jukema, J.W. (Netherlands Heart Institute)
Kähönen, M. (Tampere University)
Kamatani, Yoichiro (The University of Tokyo (Tokyo, Japó))
Kang, K.D. (The Catholic University of Korea Incheon St. Mary's Hospital)
Kaprio, Jaakko (University of Helsinki)
Kardia, S.L.R. (University of Michigan School of Public Health)
Karpe, F. (Churchill Hospital)
Kato, N. (National Center for Global Health and Medicine)
Kee, F. (Queen's University of Belfast)
Kessler, T. (German Centre for Cardiovascular Research (DZHK))
Khera, Amit V. (Massachusetts General Hospital (Boston, Estats Units d'Amèrica))
Khor, C.C. (Genome Institute of Singapore)
Kiemeney, Lambertus A. (Radboud University Medical Center)
Kim, B.J. (National Institute of Health)
Kim, E.K. (Saevit Eye Hospital)
Kim, H.L. (Ewha Womans University)
Kirchhof, P. (Atrial Fibrillation NETwork)
Kivimaki, Mika (University College London)
Koh, W.P. (National University of Singapore)
Koistinen, H.A. (Minerva Foundation Institute for Medical Research)
Kolovou, G.D. (Metropolitan Hospital)
Kooner, J.S. (Imperial College London)
Kooperberg, C. (Fred Hutchinson Cancer Research Center)
Köttgen, A. (University of Freiburg)
Kovacs, P. (University of Leipzig Medical Center)
Kraaijeveld, A. (Utrecht University)
Kraft, Peter (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica))
Krauss, R.M. (University of California)
Kumari, M. (University of Essex)
Kutalik, Zoltan (Swiss Institute of Bioinformatics (Lausanne, Suïssa))
Laakso, Markku (Kuopio University Hospital ( Finlàndia))
Lange, Leslie A. (University of Colorado at Denver)
Langenberg, C. (Charité-Universitätsmedizin Berlin)
Launer, L.J. (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Le Marchand, L. (University of Hawaii Cancer Center)
Lee, H. (Ewha Womans University School of Medicine)
Lee, N.R. (University of San Carlos)
Lehtimäki, T. (Tampere University)
Li, H. (University of Chinese Academy of Sciences)
Li, L. (Peking University Center for Public Health)
Lieb, Wolfgang (Kiel University)
Lin, X. (University of Chinese Academy of Sciences)
Lind, Lars (Uppsala University)
Linneberg, Allan (University of Copenhagen)
Liu, Ching-Ti (Boston University School of Public Health)
Liu, Junfeng (Genome Institute of Singapore)
Loeffler, Markus (University of Leipzig)
London, Barry (University of Iowa Hospitals and Clinics)
Lubitz, Steven A. (Massachusetts General Hospital (Boston, Estats Units d'Amèrica))
Lye, Stephen J. (Sinai Health System)
Mackey, David A. (University of Western Australia)
Mägi, Reedik (University of Tartu (Tartu, Estònia))
Magnusson, Patrik K. E. (Karolinska Institutet (Estocolm, Suècia))
Marcus, Gregory M. (University of California)
Vidal, Pedro M. (University of Lausanne)
Martin, Nicholas G. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
März, Winfried (Medical University of Graz)
Matsuda, Fumihiko (Kyoto University Graduate School of Medicine)
McGarrah, Robert W. (Duke University School of Medicine)
McGue, Matt (University of Minnesota (Minnesota, Estats Units d'Amèrica))
McKnight, Amy Jayne (Queen's University of Belfast)
Medland, Sarah Elizabeth (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia))
Mellström, Dan (University of Gothenburg)
Metspalu, Andres (University of Tartu (Tartu, Estònia))
Mitchell, Braxton (Baltimore Veterans Administration Medical Center)
Mitchell, Paul (University of Sydney)
Mook-Kanamori, Dennis O. (Leiden University Medical Center)
Morris, Andrew D. (University of Edinburgh)
Mucci, Lorelei A. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica))
Munroe, Patricia B. (Queen Mary University of London (Londres, Regne Unit))
Nalls, Mike A. (Data Tecnica International)
Nazarian, Saman (University of Pennsylvania)
Nelson, Amanda E. (University of North Carolina at Chapel Hill (Chapel Hill, Estats Units d'Amèrica))
Neville, Matt J. (NIHR Oxford Biomedical Research Centre. Churchill Hospital)
Newton-Cheh, Christopher (Massachusetts General Hospital (Boston, Estats Units d'Amèrica))
Nielsen, Christopher S. (Oslo University Hospital (Oslo, Noruega))
Nöthen, Markus M. (University Hospital Bonn (Bonn, Alemanya))
Ohlsson, Claes (Sahlgrenska University Hospital (Suècia))
Oldehinkel, Albertine J. (University of Groningen)
Orozco, Lorena (Instituto Nacional de Medicina Genómica)
Pahkala, Katja (University of Turku)
Pajukanta, Päivi (David Geffen School of Medicine at UCLA (Los Angeles, Estats Units d'Amèrica))
Palmer, Colin N. A. (University of Dundee)
Parra, Esteban J. (University of Toronto at Mississauga)
Pattaro, Cristian (University of Lübeck)
Pedersen, Oluf (University of Copenhagen (Copenhaguen, Dinamarca))
Pennell, Craig E. (University of Newcastle)
Penninx, Brenda W. J. H. (Amsterdam UMC and Vrije Universiteit)
Pérusse, Louis (Université Laval)
Peters, Annette (IBE. LMU Munich)
Peyser, Patricia A. (University of Michigan School of Public Health)
Porteous, David J. (University of Edinburgh)
Posthuma, Danielle (Vrije Universiteit Amsterdam)
Power, Chris (UCL Great Ormond Street Hospital Institute of Child Health)
Pramstaller, Peter P. (University of Lübeck)
Province, Michael A. (Washington University School of Medicine)
Qi, Qibin (Albert Einstein College of Medicine (Nova York, Estats Units d'Amèrica))
Qu, Jia (Wenzhou Medical University)
Rader, Daniel J. (University of Pennsylvania (Filadèlfia, Estats Units d'Amèrica))
Raitakari, Olli T. (Turku University Hospital (Finlàndia))
Ralhan, Sarju (Dyanand Medical College)
Rallidis, Loukianos S. (University General Hospital Attikon (Haidari, Grècia))
Rao, Dabeeru C. (Washington University School of Medicine)
Redline, Susan (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Reilly, Dermot F. (Merck Sharp & Dohme Genetics)
Reiner, Alexander P. (University of Washington)
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Ridker, Paul M. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Rienstra, Michiel (University Medical Center Groningen)
Ripatti, Samuli (University of Helsinki)
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Roden, Dan M. (Vanderbilt University Medical Center)
Rosendaal, Frits (Leiden University Medical Center)
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Samani, Nilesh J. (Glenfield Hospital (Leicester, Regne Unit))
Sanghera, Dharambir K. (University of Oklahoma Health Sciences Center)
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Schmidt, Börge (University Hospital Essen (Alemanya))
Schmidt, Helena (Medical University of Graz)
Schmidt, Reinhold (Medical University of Graz)
Schulze, Matthias B. (University of Potsdam)
Schunkert, Heribert (Technische Universität München)
Scott, Laura J. (University of Michigan School of Public Health (Ann Arbor, Estats Units d'Amèrica))
Scott, Rodney J. (University of Newcastle)
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Shoemaker, M. Benjamin (Vanderbilt University Medical Center)
Shu, Xiao-Ou (Vanderbilt University Medical Center)
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Singleton, Andrew B. (National Institute on Aging (Estats Units d'Amèrica))
Sinner, Moritz F. (Ludwig-Maximilians-University Munich)
Smith, J. Gustav (Lund University)
Snieder, Harold (University Medical Center Groningen (Groningen, Països Baixos))
Spector, Tim (King's College London)
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Tabara, Yasuharu (Kyoto University Graduate School of Medicine)
Tang, Hua (Stanford University School of Medicine)
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Tönjes, A. (University of Leipzig Medical Center)
Tremblay, A. (Université Laval)
Tuomi, T. (Folkhälsan Research Center)
Tuomilehto, J. (King Abdulaziz University)
Tusié-Luna, M.T. (Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán)
Uitterlinden, André G. (University Medical Center Rotterdam (Rotterdam, Països Baixos))
van Dam, Rob M. (The George Washington University)
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Van der Velde, Nathalie (Amsterdam Public Health)
van Duijn, Cornelia M. (University Medical Center Rotterdam)
van Schoor, N.M. (Amsterdam University Medical Center (UMC))
Vitart, Veronique (University of Edinburgh)
Völker, U. (University Medicine Greifswald)
Vollenweider, P. (University of Lausanne)
Völzke, Henry (DZHK (German Centre for Cardiovascular Research))
Wacher-Rodarte, N.H. (Centro Médico Nacional Siglo XXI)
Walker, M. (Newcastle University)
Wang, Y.X. (Capital Medical University)
Wareham, N.J. (University of Cambridge School of Clinical Medicine)
Watanabe, R.M. (Keck School of Medicine of USC)
Watkins, Hugh (University of Oxford (Oxford, Regne Unit))
Weir, D.R. (University of Michigan)
Werge, Thomas M. (University of Copenhagen (Copenhaguen, Dinamarca))
Widen, E. (University of Helsinki)
Wilkens, Lynne R. (University of Hawaii Cancer Center)
Willemsen, Gonneke (Vrije Universiteit Amsterdam)
Willett, Walter C. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica))
Wilson, James F. (Western General Hospital (Edimburg, Escòcia))
Wong, Tien-Yin (Duke-NUS Medical School)
Woo, Jeong-Taek (Kyung Hee University School of Medicine)
Wright, Alan F. (University of Edinburgh)
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Xu, Huichun (University of Maryland School of Medicine)
Yajnik, Chittaranjan S. (King Edward Memorial Hospital and Research Centre)
Yokota, Mitsuhiro (Kurume University School of Medicine (Kurume, Japó))
Yuan, Jian-Min (University of Pittsburgh)
Zeggini, Eleftheria (Technical University of Munich)
Zemel, Babette S. (University of Pennsylvania)
Zheng, Wei (Vanderbilt University Medical Center)
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Zmuda, Joseph M. (University of Pittsburgh)
Zonderman, Alan B. (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Zwart, John-Anker (University of Oslo)
Croteau-Chonka, Damien (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Vonk, Judith M. (University Medical Center Groningen (Groningen, Països Baixos))
Le Marchand, Loic (University of Hawaii Cancer Center)
Chasman, Daniel I. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Cho, Yoon Shin (Hallym University (Chuncheon, Corea del Sud))
Heid, Iris M. (University of Regensburg)
McCarthy, Mark I. (Genentech (South San Francisco, Estats Units))
Ng, Maggie C. Y. (Vanderbilt University Medical Center)
O'Donnell, Christopher J. (Veterans Affairs Boston Healthcare System)
Rivadeneira, Fernando (Erasmus Medical Center Rotterdam (Rotterdam, Països Baixos))
Thorsteinsdottir, Unnur (University of Iceland)
Sun, Yan V. (Atlanta VA Health Care System)
Tai, E. Shyong (National University Health System (Singapur))
Boehnke, Michael (University of Michigan School of Public Health (Ann Arbor, Estats Units d'Amèrica))
Deloukas, Panos (King Abdulaziz University (Jeddah, Aràbia Saudita))
Justice, Anne E. (Geisinger Health System (Danville, Estats Units). Department of Population Health Sciences)
Lindgren, Cecilia M. (University of Oxford (Oxford, Regne Unit))
Loos, Ruth J. F. (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Mohlke, Karen L. (University of North Carolina at Chapel Hill (Chapel Hill, Estats Units d'Amèrica))
North, Kari E. (University of North Carolina at Chapel Hill (Chapel Hill, Estats Units d'Amèrica))
Stefánsson, Kári (University of Iceland)
Walters, Robin G. (University of Oxford (Oxford, Regne Unit)))
Winkler, Thomas W. (University of Regensburg (Regensburg, Alemanya))
Young, Kristin L. (University of North Carolina at Chapel Hill (Chapel Hill, Estats Units d'Amèrica))
Loh, Po-Ru (Harvard Medical School)
Yang, Jian (Westlake Laboratory of Life Sciences and Biomedicine (Hangzhou, Xina))
Esko, Tõnu (University of Tartu (Tartu, Estònia))
Assimes, Themistocles (Stanford University School of Medicine)
Auton, Adam (23andMe (California, Estats Units d'Amèrica))
Abecasis, Goncalo (University of Michigan School of Public Health (Ann Arbor, Estats Units d'Amèrica))
Willer, Cristen J. (University of Michigan (Michigan, Estats Units d'Amèrica))
Locke, Adam E. (Washington University School of Medicine)
Berndt, Sonja (National Cancer Institute (Rocville, Estats Units))
Lettre, Guillaume (Université de Montréal)
Frayling, Timothy M. (University of Exeter (Devon, Anglaterra))
Okada, Yukinori (The University of Tokyo (Tokyo, Japó))
Wood, Andrew R. (University of Exeter (Exter, Regne Unit))
Visscher, PM. (University of Queensland (Queensland, Austràlia))
Hirschhorn, Joel N. (Harvard Medical School)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using data from a genome-wide association study of 5. 4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.
Ajuts:	European Commission 634935 European Commission 633784 European Commission 755320 European Commission 848146 European Commission ERC-2017-STG-757364 European Commission ERC-CoG-2015-681466 European Commission CoG-2015_681742_NASCENT European Commission ERC-2011-StG 280559-SEPI European Commission ERC-STG-2015-679242 European Commission 742927 European Commission ERC-230374 Ministerio de Economía y Competitividad PI15/00069 Ministerio de Ciencia e Innovación RD09/0076/00036 Ministerio de Ciencia e Innovación PI11/01889
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Gene Frequency ; Genome ; Genome-Wide Association Study ; Humans ; Linkage Disequilibrium ; Polymorphism, Single Nucleotide
Publicat a:	Nature, Vol. 610 Núm. 7933 (27 2022) , p. 704-712, ISSN 1476-4687

DOI: 10.1038/s41586-022-05275-y
PMID: 36224396

35 p, 18.8 MB

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