Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients : what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?
Baeza, Inmaculada (Hospital Clínic i Provincial de Barcelona)
de la Serna, Elena (Hospital Clínic i Provincial de Barcelona)
Mezquida, Gisela (Hospital Clínic i Provincial de Barcelona)
Cuesta, Manuel J. (Complejo Hospitalario de Navarra)
Vieta, Eduard (Hospital Clínic i Provincial de Barcelona)
Amoretti, Silvia (Hospital Universitari Vall d'Hebron)
Lobo, Antonio (Universidad de Zaragoza)
González-Pinto, Ana (Arabako Unibertsitate Ospitalea (Vitoria, País Basc))
Díaz-Caneja, Covadonga M. (Hospital General Universitario Gregorio Marañón)
Corripio, Iluminada (Institut de Recerca Sant Pau)
Valli, Isabel (King's College London)
Puig, Olga (Hospital Clínic i Provincial de Barcelona)
Mané, Anna (Institut Hospital del Mar d'Investigacions Mèdiques)
Bioque, Miquel (Hospital Clínic i Provincial de Barcelona)
Ayora, Miriam (Hospital General Universitario Gregorio Marañón)
Bernardo, Miquel (Hospital Clínic i Provincial de Barcelona)
Castro-Fornieles, Josefina (Hospital Clínic i Provincial de Barcelona)
Garcia Rizo, Clemente (Hospital Clínic i Provincial de Barcelona)
González-Díaz, Jairo (Hospital Clínic i Provincial de Barcelona)
Grasa, Eva (Institut de Recerca Sant Pau)
Roldan-Bejarano, Alexandra (Institut de Recerca Sant Pau)
Casanovas, Francesc (Institut Hospital del Mar d'Investigacions Mèdiques)
Toll, Alba (Institut Hospital del Mar d'Investigacions Mèdiques)
Verdolini, Norma (Hospital Clínic i Provincial de Barcelona)
Sagué-Vilabella, Maria (Hospital Clínic i Provincial de Barcelona)
Sugranyes, Gisela (Hospital Clínic i Provincial de Barcelona)
Ilzarbe, Daniel (Hospital Clínic i Provincial de Barcelona)
Contreras, Fernando (Institut d'Investigació Biomèdica de Bellvitge)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptoms in a sample of patients with a first episode of psychosis. 331 patients with a first episode of psychosis (7-35 years old) were recruited and 174 (52. 6%) diagnosed with SSD or BD at one-year follow-up through a multicenter longitudinal study. The Symptom Onset in Schizophrenia (SOS) inventory, the Positive and Negative Syndrome Scale and the structured clinical interviews for DSM-IV diagnoses were administered. Generalized linear models compared the main effects and group interaction. 273 AOP (25. 2 ± 5. 1 years; 66. 5% male) and 58 EOP patients (15. 5 ± 1. 8 years; 70. 7% male) were included. EOP patients had significantly more prodromal symptoms with a higher frequency of trouble with thinking, avolition and hallucinations than AOP patients, and significantly different median DUP (91 [33-177] vs. 58 [21-140] days; Z = - 2. 006, p = 0. 045). This was also significantly longer in SSD vs. BD patients (90 [31-155] vs. 30 [7-66] days; Z = - 2. 916, p = 0. 004) who, moreover had different profiles of prodromal symptoms. When assessing the interaction between age at onset (EOP/AOP) and type of diagnosis (SSD/BD), avolition was significantly higher (Wald statistic = 3. 945; p = 0. 047), in AOP patients with SSD compared to AOP BD patients (p = 0. 004). Awareness of differences in length of DUP and prodromal symptoms in EOP vs. AOP and SSD vs. BD patients could help improve the early detection of psychosis among minors.
Ajuts:	Ministerio de Ciencia e Innovación PI11/00325 Ministerio de Economía y Competitividad PI14/00612
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adult onset ; Children and adolescents ; Prodrome ; Prodromal symptoms ; Schizophrenia, bipolar disorder, early onset
Publicat a:	European child and adolescent psychiatry, Vol. 33 (april 2024) , p. 799-810, ISSN 1435-165X

DOI: 10.1007/s00787-023-02196-7
PMID: 37027026

12 p, 848.7 KB

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