Characteristics of 24 SARS-CoV-2-Sequenced Reinfection Cases in a Tertiary Hospital in Spain
Borras Bermejo, Blanca (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Piñana, Maria (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Andrés, Cristina (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Zules-Oña, Ricardo (Hospital Universitari Vall d'Hebron. Institut de Recerca)
González-Sánchez, Alejandra (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Esperalba, Juliana (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Parés-Badell, Oleguer (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Garcia-Cehic, D (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Rando-Segura, Ariadna (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Campos, Carolina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Codina, María Gema (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Martín, Maria Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Castillo, Carla (Hospital Universitari Vall d'Hebron. Institut de Recerca)
García-Comuñas, Karen (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Vásquez-Mercado, Rodrigo (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Martins-Martins, Reginald (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Colomer-Castell, Sergi (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Pumarola Suñé, Tomàs (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Campins Martí, Magda (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Quer, Josep 1963- (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Antón, Andrés 1976- (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the main concern is whether reinfections are possible, and which are the associated risk factors. This study aims to describe the clinical and molecular characteristics of 24 sequence-confirmed reinfection SARS-CoV-2 cases over 1 year in Barcelona (Catalonia, Spain). Patients with > 45 days between two positive PCR tests regardless of symptoms and negative tests between episodes were initially considered as suspected reinfection cases from November 2020 to May 2021. Whole-genome sequencing (WGS) was performed to confirm genetic differences between consensus sequences and for phylogenetic studies based on PANGOLIN nomenclature. Reinfections were confirmed by the number of mutations, change in lineage, or epidemiological criteria. From 39 reported suspected reinfection cases, complete viral genomes could be sequenced from both episodes of 24 patients, all were confirmed as true reinfections. With a median age of 44 years (interquartile range [IQR] 32-65), 66% were women and 58% were healthcare workers (HCWs). The median days between episodes were 122 (IQR 72-199), occurring one-third within 3 months. Reinfection episodes were frequently asymptomatic and less severe than primary infections. The absence of seroconversion was associated with symptomatic reinfections. Only one case was reinfected with a variant of concern (VOC). Severe acute respiratory syndrome coronavirus 2 reinfections can occur in a shorter time than previously reported and are mainly found in immunocompetent patients. Surveillance through WGS is useful to identify viral mutations associated with immune evasion.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	SARS-CoV-2 ; COVID-19 ; Reinfection ; Whole-genome sequencing ; Clinical features
Publicat a:	Frontiers in microbiology, Vol. 13 (may 2022) , ISSN 1664-302X

DOI: 10.3389/fmicb.2022.876409
PMID: 35722299

10 p, 1.4 MB

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