Myocardial Injury in COVID-19 and Its Implications in Short- and Long-Term Outcomes
Izquierdo Marquisá, Andrea (Universitat Autònoma de Barcelona. Departament de Medicina)
Cubero-Gallego, Hector (Institut Hospital del Mar d'Investigacions Mèdiques)
Aparisi, Álvaro (Institut Hospital del Mar d'Investigacions Mèdiques)
Vaquerizo, Beatriz (Institut Hospital del Mar d'Investigacions Mèdiques)
Ribas Barquet, Núria (Hospital del Mar (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Data:	2022
Resum:	COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still a pandemic with high mortality and morbidity rates. Clinical manifestation is widely variable, including asymptomatic or mild respiratory tract illness to severe pneumonia and death. Myocardial injury is a significant pathogenic feature of COVID-19 and it is associated with worse in-hospital outcomes, mainly due to a higher number of hospital readmissions, with over 50% mortality. These findings suggest that myocardial injury would identify COVID-19 patients with higher risk during active infection and mid-term follow-up. Potential contributors responsible for myocardial damage are myocarditis, vasculitis, acute inflammation, type 1 and type 2 myocardial infarction. However, there are few data about cardiac sequelae and its long-term consequences. Thus, the optimal screening tool for residual cardiac sequelae, clinical follow-up, and the benefits of a specific cardiovascular therapy during the convalescent phase remains unknown. This mini-review explores the different mechanisms of myocardial injury related to COVID-19 and its short and long-term implications.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Biomarkers ; COVID-19 ; Infection ; Inflammation ; Organ failure ; Prognosis ; SARS CoV-2
Publicat a:	Frontiers in Cardiovascular Medicine, Vol. 9 (may 2022) , ISSN 2297-055X

DOI: 10.3389/fcvm.2022.901245
PMID: 35722133

7 p, 2.1 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats