Cariprazine Use in Combination With a Mood Stabilizer in First Episode Mania
Palacios-Garrán, Roberto (GSS-Hospital Santa Maria)
Llorca-Bofí, Vicent (GSS-Hospital Santa Maria)
Arteaga-Henriquez, Gara (Hospital Universitari Vall d'Hebron)
del Agua, Enrique (GSS-Hospital Santa Maria)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Cariprazine's efficacy and safety have been previously tested in adult patients with acute mania associated with bipolar I disorder, but there is no available data in FEM. The objective of this study is to assess the efficacy and safety of cariprazine in combination with a mood stabilizer in treating FEM as well as to evaluate patients' adherence to the treatment. FEM patients were recruited from the acute inpatient unit at Lleida University Hospital Santa Maria, between January and June 2021. Their symptoms were evaluated using the Young Mania Rating Scale (YMRS) and the Clinical Global Impressions-Severity (CGI-S) scale at admission and at discharge. Akathisia was assessed using the Barnes Akathisia Rating Scale. Patient adherence to medication treatment was assessed 30 days after discharge using the Morisky, Green and Levine Medication Adherence Scale. Socio-demographic and clinical information were further collected. Eleven patients with FEM were involved, seven women and four men. Their mean age was 26. 00+/-6. 37 years. Mean hospitalization was 17. 36+/-4. 7 days. Cariprazine was combined with a mood stabilizer: lithium in seven patients and divalproex in four. Mean YMRS change from baseline was -24. 55+/-7. 5 and the mean CGI-S change from baseline was -2. 55+/-0. 82. Regarding adverse events, two (18. 2%) patients presented with akathisia. At the 30-day treatment-adherence assessment, six (54. 5%) patients were adherent and four (36. 4%) had moderate adherence. In this sample, cariprazine in combination with mood stabilizers proved to be safe and effective in the treatment of FEM with more than half the patients being adherent to treatment. Therefore, cariprazine add-on is a good choice for promoting the long-term adherence of patients, thus minimizing the risk of relapse and improving prognosis.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Acute mania ; Bipolar disoder ; Cariprazine ; First episode mania ; Presicion medicine ; Treatment adherence
Publicat a:	Frontiers in psychiatry, Vol. 13 (may 2022) , ISSN 1664-0640

DOI: 10.3389/fpsyt.2022.828088
PMID: 35633804

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