Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study
Weiss, Scott L. (The Children's Hospital of Philadelphia)
Fitzgerald, JulieC. (University of Pennsylvania Perelman School of Medicine)
Maffei, Frank (Janet Weis Children's Hospital/Geisinger Health System)
Kane, Jason M. (University of Chicago Medicine)
Rodriguez-Nunez, Antonio (Hospital Clínico Universitario)
Hsing, Deyin D. (Weill Cornell Medical Center)
Franzon, Deborah (Stanford University)
Kee, Sze Ying (University Malaya Medical Centre)
Bush, Jenny L. (The Children's Hospital of Philadelphia)
Roy, Jason A. (University of Pennsylvania Perelman School of Medicine)
Thomas, Neal J. (Penn State Hershey Medical Center)
Nadkarni, Vinay M. (University of Pennsylvania Perelman School of Medicine)
Fontela, Patricia S. (Montreal Children's Hospital-McGill University Health Centre (Canadà))
Tucci, Marisa (Sainte Justine Hospital (Canadà))
Dumistrascu, M. (Sainte Justine Hospital (Canadà))
Skippen, Peter W. (BC Children's Hospital (Canadà))
Krahn, Gordon E. (BC Children's Hospital (Canadà))
Bezares, E. (Centro Cardiovascular de Puerto Rico y el Caribe)
Puig, Gilberto (San Jorge Children's Hospital (Puerto Rico))
Puig-Ramos, Anabel (San Jorge Children's Hospital (Puerto Rico))
Garcia, R. (University Pediatric Hospital (Puerto Rico))
Villar, M. (University Pediatric Hospital (Puerto Rico))
Bigham, Michael Theodore (Akron Children's Hospital (Akron, Estats Units d'Amèrica))
Polanski, T. (Akron Children's Hospital (Akron, Estats Units d'Amèrica))
Latifi, Samir Qamar (Akron Children's Hospital (Akron, Estats Units d'Amèrica))
Giebner, D. (Akron Children's Hospital (Akron, Estats Units d'Amèrica))
Anthony, Heather (Akron Children's Hospital (Akron, Estats Units d'Amèrica))
Hume, Janet (Amplatz Children's Hospital (Estats Units d'Amèrica))
Galster, Amanda (Amplatz Children's Hospital (Estats Units d'Amèrica))
Linnerud, L. (Amplatz Children's Hospital (Estats Units d'Amèrica))
Sanders, Ronald C. (Arkansas Children's Hospital (Estats Units d'Amèrica))
Hefley, Glenda C. (Arkansas Children's Hospital (Estats Units d'Amèrica))
Madden, Kate (Boston Children's Hospital (Boston, Estats Units d'Amèrica))
Thompson, Ann E. (Children's Hospital of Pittsburgh (Estats Units d'Amèrica))
Shein, Steven L. (Children's Hospital of Pittsburgh (Estats Units d'Amèrica))
Gertz, Shira J. (Joseph M. Sanzari Children's Hospital-Hackensack University Medical Center (Estats Units d'Amèrica))
Han, Yongyun (Children's Mercy Hospital (Kansas, Estats Units d'Amèrica))
Williams, Trisha (Children's Mercy Hospital (Kansas, Estats Units d'Amèrica))
Hughes-Schalk, Amber (Children's Mercy Hospital (Kansas, Estats Units d'Amèrica))
Chandler, Heather K. (Children's Healthcare of Atlanta (Atlanta, Estats Units d'Amèrica))
Orioles, Alberto (Children's St. Paul Pediatric Hospital (Minnesota, Estats Units d'Amèrica))
Zielinski, Erin E. (Children's St. Paul Pediatric Hospital (Minnesota, Estats Units d'Amèrica))
Doucette, Angela (Children's St. Paul Pediatric Hospital (Minnesota, Estats Units d'Amèrica))
Zebuhr, Carleen A. (Children's Hospital Colorado (Aurora, Estats Units d'Amèrica))
Wilson, T. (Children's Hospital Colorado (Aurora, Estats Units d'Amèrica))
Dimitriades, Constantine (Children's Hospital (Nova Orleans, Estats Units d'Amèrica))
Ascani, J. (Children's Hospital (Nova Orleans, Estats Units d'Amèrica))
Layburn, S. (Children's Hospital (Nova Orleans, Estats Units d'Amèrica))
Valley, S. (Children's Hospital (Nova Orleans, Estats Units d'Amèrica))
Markowitz, B. (Children's Hospital Los Angeles (Estats Units d'Amèrica))
Terry, Jeff (Children's Hospital Los Angeles (Estats Units d'Amèrica))
Morzov, Rica Sharon P. (Children's Hospital Los Angeles (Estats Units d'Amèrica))
McInnes, Andrew D. (Unterberg Children's Hospital at Monmouth Medical Center (Estats Units d'Amèrica))
McArthur, Jennifer Ann (Children's Hospital of Wisconsin (Estats Units d'Amèrica))
Woods, Katherine (Children's Hospital of Wisconsin (Estats Units d'Amèrica))
Murkowski, Kathy (Children's Hospital of Wisconsin (Estats Units d'Amèrica))
Spaeder, Michael (Children's National Medical Center (Estats Units d'Amèrica))
Sharron, Matthew P. (Children's National Medical Center (Estats Units d'Amèrica))
Wheeler, Derek S. (Cincinnati Children's Hospital Medical Center)
Beckman, Eileen C. (Cincinnati Children's Hospital Medical Center)
Frank, Erin (Cincinnati Children's Hospital Medical Center)
Howard, Kelli A. (Cincinnati Children's Hospital Medical Center)
Carroll, Christopher L. (Connecticut Children's Medical Center)
Nett, Sholeen T. (Dartmouth-Hitchcock Medical Center)
Jarvis, Dean (Dartmouth-Hitchcock Medical Center)
Patel, Viren D. (Dayton Children's Hospital)
Higgerson, Renee A. (Dell Children's Medical Center of Central Texas)
Christie, Lee Ann Mc Coy (Dell Children's Medical Center of Central Texas)
Typpo, Katri V. (Diamond Children's Medical Center)
Deschenes, Jendar (Diamond Children's Medical Center)
Kirby, Aileen L. (Doernbecher Children's Hospital)
Uhl, Tammy L. (Duke Children's Hospital and Health Center)
Rehder, Kyle J. (Duke Children's Hospital and Health Center)
Cheifetz, Ira (Duke Children's Hospital and Health Center)
Wrenn, S. (Duke Children's Hospital and Health Center)
Kypuros, K. (El Paso Children's Hospital)
Ackerman, Kate G. (Golisano Children's Hospital)
Maffei, F. (Janet Weis Children's Hospital/Geisinger Health System)
Bloomquist, G. (Janet Weis Children's Hospital/Geisinger Health System)
Rizkalla, Nicole A. (Johns Hopkins Hospital (Baltimore, Estats Units d'Amèrica))
Kimura, Dai (Le Bonheur Children's Hospital (Memphis, Estats Units d'Amèrica))
Shah, Samir S. (Le Bonheur Children's Hospital (Memphis, Estats Units d'Amèrica))
Tigges, Cody (Le Bonheur Children's Hospital (Memphis, Estats Units d'Amèrica))
Su, Felice (Lucile Packard Children's Hospital (Estats Units d'Amèrica))
Barlow, Courtenay (Lucile Packard Children's Hospital (Estats Units d'Amèrica))
Michelson, Kelly Nicole (Ann and Robert H. Lurie Children's Hospital of Chicago)
Wolfe, Katie (Ann and Robert H. Lurie Children's Hospital of Chicago)
Goodman, Denise (Ann and Robert H. Lurie Children's Hospital of Chicago)
Campbel, L. (Ann and Robert H. Lurie Children's Hospital of Chicago)
Sorce, Lauren (Ann and Robert H. Lurie Children's Hospital of Chicago)
Bysani, Krisa G. (Medical City Children's Hospital-Dallas (Dallas, Estats Units d'Amèrica))
Monjure, Tracey (Medical City Children's Hospital-Dallas (Dallas, Estats Units d'Amèrica))
Evans, Melissa C. (Medical University of South Carolina)
Totapally, Balagangadhar R. (Miami Children's Hospital)
Chegondi, Madhuradhar (Miami Children's Hospital)
Cabrera Rodriguez, Carlos (Miami Children's Hospital)
Frazier, Jean A. (Nationwide Children's Hospital)
Steele, Lisa M. (Nationwide Children's Hospital)
Viteri, Shirley (Nemours/Alfred I. duPont Hospital for Children (Wilmington, Estats Units d'Amèrica))
Costarino, Andrew Thomas (Nemours/Alfred I. duPont Hospital for Children (Wilmington, Estats Units d'Amèrica))
Spear, Debbie A. (Penn State Hershey Medical Center)
Hirshberg, Ellie L. (Primary Children's Medical Center (Salt Lake City, Estats Units d'Amèrica))
Lilley, Jennifer (Primary Children's Medical Center (Salt Lake City, Estats Units d'Amèrica))
Rowan, Courtney M. (Riley Hospital for Children (Indiana, Estats Units d'Amèrica))
Rider, C. (Riley Hospital for Children (Indiana, Estats Units d'Amèrica))
Kane, J.. (Rush Children's Hospital (Skokie, Estats Units d'Amèrica))
Zimmerman, Jerry J. (Seattle Children's Hospital (Seattle, Estats Units d'Amèrica))
Greeley, Christy (Seattle Children's Hospital (Seattle, Estats Units d'Amèrica))
Lin, John C. (St. Louis Children's Hospital (St. Louis, Estats Units d'Amèrica))
Jacobs, Rachel A. (St. Louis Children's Hospital (St. Louis, Estats Units d'Amèrica))
Parker, Margaret M. (Stony Brook University (Stony Brook, Estats Units d'Amèrica))
Culver, Kathleen (Stony Brook University (Stony Brook, Estats Units d'Amèrica))
Loftis, Laura L. (Texas Children's Hospital (Texas, Estats Units d'Amèrica))
Jaimon, Nancy (Texas Children's Hospital (Texas, Estats Units d'Amèrica))
Goldsworthy, Michelle (Texas Children's Hospital (Texas, Estats Units d'Amèrica))
Fitzgerald, J. E. F. (The Children's Hospital of Philadelphia (Estats Units d'Amèrica))
Nadkarni, Vinay M. (The Children's Hospital of Philadelphia (Estats Units d'Amèrica))
Bush, J. (The Children's Hospital of Philadelphia (Estats Units d'Amèrica))
Diliberto, Mary Ann (The Children's Hospital of Philadelphia (Estats Units d'Amèrica))
Alen, C. (Oklahoma University Medical Center)
Gessouroun, Morris R. (Oklahoma University Medical Center)
Sapru, Anil (University of California San Francisco)
Lang, Trudie A. (University of California San Francisco)
Alkhouli, Mustafa F. (University of California San Francisco)
Kamath, Sameer S. (University of Iowa)
Friel, D. (University of Iowa)
Daufeldt, Jennifer (University of Iowa)
Hsing, D. (Weill Cornell Medical Center)
Carlo, Charlene D. (Weill Cornell Medical Center)
Pon, Steven (Weill Cornell Medical Center)
Scimeme, Jason P. (Wolfson Children's Hospital)
Shaheen, A. (Wolfson Children's Hospital)
Hassinger, Amanda B. (Women and Children's Hospital of Buffalo)
Qiao, Haiping (Women and Children's Hospital of Buffalo)
Giuliano, John S. (Yale-New Haven Children's Hospital)
Tala, Joana A. (Yale-New Haven Children's Hospital)
Vinciguerra, D. (Hospital Carlos G. Durand)
Fernández, Analía (Royal Manchester Children's Hospital)
Carrero, Rosalba Pardo (Clínica Infantil Colsubsidio)
Hoyos, Pablo Vasquez (Hospital de San José)
Jaramillo, Joaquín (Hospital General de Medellín (Colombia))
Posada, A. (Hospital General de Medellín (Colombia))
Izquiierdo, L. (Central Military Hospital (Colombia))
Piñeres Olave, Byron Enrique (Hospital Pablo Tobón Uribe (Colombia))
Donado-Gómez, Jorge H. (Hospital Pablo Tobón Uribe (Colombia))
Dalmazzo, Roberto (Clínica Las Condes (Xile))
Rendich, S. (Clínica Las Condes (Xile))
Palma, L. (Clínica Santa María (Xile))
Lapadula, Michelangelo A. (Clínica Santa María (Xile))
Acuna-Villaorduna, Carlos (Hospital Luis Calvo Mackenna (Xile))
Cruces, Pablo (Hospital Padre Hurtado (Xile))
Clement De Clety, Stephan (St. Luc University Hospital)
Dujardin, Marie France (St. Luc University Hospital (Bèlgica))
Berghe, Caroline (St. Luc University Hospital (Bèlgica))
Renard, Suzanne (St. Luc University Hospital (Bèlgica))
Zurek, Jiri (Masaryk University (Txèquia))
Steinherr, Harry M. (Klinikum Augsburg (Alemanya))
Mougkou, Aikaterini (P. and A. Kyriakou Children's Hospital)
Critselis, Elena (P. and A. Kyriakou Children's Hospital)
Di Nardo, Matteo (Bambino Gesu Area Rossa (Lituània))
Picardo, Sergio Giuseppe (Bambino Gesu Area Rossa (Lituània))
Tortora, Francesca (Bambino Gesu Area Rossa (Lituània))
Rossetti, Emanuele (Bambino Gesù Hospital (Palidoro, Itàlia))
Fragasso, T. (Bambino Gesu Pediatrico (Lituània))
Cogo, Paola (Bambino Gesu Pediatrico (Lituània))
Netto, Roberta (Bambino Gesu Pediatrico (Lituània))
Dagys, Algirdas (Lithuanian University of Health Sciences (Lituània))
Gurskis, Vaidotas (Lithuanian University of Health Sciences (Lituània))
Kevalas, Rimantas (Lithuanian University of Health Sciences (Lituània))
Neeleman, Chris (Radboud University Medical Centre (Països Baixos))
Lemson, Joris (Radboud University Medical Centre (Països Baixos))
Luijten, C. (Radboud University Medical Centre (Països Baixos))
Wojciech, Klonek (Polish Mother Memorial Hospital (Polònia))
Pagowska-Klimek, Izabela (Polish Mother Memorial Hospital (Polònia))
Szczepanska, Maria (Stanislawa Szyszko Slaskiego University (Polònia))
Karpe, Jacek W. (Stanislawa Szyszko Slaskiego University (Polònia))
Nunes, P. (Hospital Prof Doutor Fernando Fonseca (Portugal))
Almeida, Helena Isabel (Hospital Prof Doutor Fernando Fonseca (Portugal))
Rios, J. (Centro Hospitalar Lisboa Norte (Portugal))
Vieira, Marisa (Centro Hospitalar Lisboa Norte (Portugal))
Revilla, Paula Madurga (Hospital Universitario Miguel Servet (Saragossa))
Urbano, Javier (Hospital General Universitario Gregorio Marañón)
Lopez-Herce, Jesus (Hospital General Universitario Gregorio Marañón)
Bustinza, Amaya (Hospital General Universitario Gregorio Marañón)
Cuesta, Alba Palacios (Hospital 12 de Octubre (Madrid))
Hofheinz, Sylvia Belda (Hospital 12 de Octubre (Madrid))
Rodriguez-Nunez, A. (Hospital Clínico Universitario)
Brió Sanagustín, Sonia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Gonzalez, Esther Lanzós (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Riaza Gómez, Mónica (Hospital Universitario de Madrid)
Piaya, R. (Hospital Universitario de Madrid)
Soler, Patricia Garcia (Hospital Regional Universitario Carlos Haya Hospital Materno-Infantil (Màlaga))
Esteban-Torné, Elisabeth (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Laraudogoitia, J. (Hospital de Donostia (Sant Sebastià, País Basc))
Monge, Cristina Calvo (Hospital de Donostia (Sant Sebastià, País Basc))
Herrera, V. Murga (Hospital Universitario de Salamanca)
Granados, J. (Hospital Universitario de Salamanca)
Gonzalez, Cristina Carpizo (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Koroglu, Tolga Fikri (Dokuz Eylül University (Ankara, Turquia))
Ozcelik, Emine Tulay (Dokuz Eylül University (Ankara, Turquia))
Baines, Paul B. (Alder Hey Children's Hospital (Regne Unit))
Plunkett, Adrian C. (Birmingham Children's Hospital)
Davis, Peter J. (Bristol Royal Hospital for Children (Regne Unit))
George, Shane (Bristol Royal Hospital for Children (Regne Unit))
Tibby, Shane M. (Evelina Children's Hospital (Regne Unit))
Harris, Julia (Evelina Children's Hospital (Regne Unit))
Agbeko, Rachel (Great North Children's Hospital- Newcastle)
Lampitt, R. (Great North Children's Hospital- Newcastle)
Bierley, J. (Great Ormond Street Hospital for Children (Londres, Regne Unit))
Peters, Mark (Great Ormond Street Hospital for Children (Londres))
Jones, Andrew J. (Great Ormond Street Hospital for Children (Londres, Regne Unit))
Dominguez, Troy E. (Great Ormond Street Hospital for Children (Londres, Regne Unit))
Thiruchelvam, Timothy (Great Ormond Street Hospital for Children (Londres, Regne Unit))
Deep, Akash (King's College Hospital NHS Foundation Trust (Londres, Regne Unit))
Ridley, L. (King's College Hospital NHS Foundation Trust (Londres, Regne Unit))
Bowen, W. (King's College Hospital NHS Foundation Trust (Londres, Regne Unit))
Levin, Richard (Royal Hospital for Sick Children (Londres, Regne Unit))
Macleod, Isobel (Royal Hospital for Sick Children (Londres, Regne Unit))
Gray, Martin Peter (St George's Hospital (Londres, Regne Unit))
Hemat, Nargis (St George's Hospital (Londres, Regne Unit))
Alexander, Janet (University Hospital of North Staffordshire NHS Trust (Regne Unit))
Ali, Souad (University Hospital of North Staffordshire NHS Trust (Regne Unit))
Pappachan, John V. P. (University Hospitals of North Midlands NHS Trust (Regne Unit))
McCorkell, Jenni (University Hospitals of North Midlands NHS Trust (Regne Unit))
Schibler, Andreas (Royal Manchester Children's Hospital (Austràlia))
Fernandez, Alicia (Royal Manchester Children's Hospital (Austràlia))
Fortune, Peter Marc (Mater Children's Hospital (Austràlia))
MacDonald, M. (Mater Children's Hospital (Austràlia))
Hudnott, Phil (Mater Children's Hospital (Austràlia))
Erickson, Simon J. (Princess Margaret Hospital for Children (Austràlia))
Millar, Johnny (Royal Children's Melbourne (Austràlia))
Delzoppo, Carmel (Sydney Children's Hospital (Austràlia))
Williams, Gary D. (Sydney Children's Hospital (Austràlia))
Morritt, Mary Lou (Children's Hospital at Westmead (Austràlia))
McEneiry, J. (Royal Children's Hospital Brisbane (Austràlia))
Long, Debbie (Royal Children's Hospital Brisbane (Austràlia))
Dorofaeff, Tavey (Royal Children's Hospital Brisbane (Austràlia))
Coulthard, Mark G. (Royal Children's Hospital Brisbane (Austràlia))
Watts, N. (Children's Hospital at Westmead)
Morritt, M. (Children's Hospital at Westmead)
Suyun, Q. (Beijing Children's Hospital)
Singhi, S. (Advanced Pediatrics Centre)
Nallasamy, K. (Advanced Pediatrics Centre)
Lodha, R. (All India Institute of Medical Sciences (Nova Delhi, Índia))
Shime, N. (Kyoto Prefectural University of Medicine)
Tabata, Y. (Kyoto Prefectural University of Medicine)
Saito, O. (Tokyo Metropolitan Children's Medical Center)
Ikeyama, T. (Tokyo Metropolitan Children's Medical Center)
Kawasaki, T. (Shizuoka Children's Hospital)
Lum, L. (University Malaya Medical Centre)
Abidin, A. (University Malaya Medical Centre)
Kee, S. (University Malaya Medical Centre)
Tang, S. (UKM Medical Centre)
Jalil, R. (UKM Medical Centre)
Beca, J. (Starship Children's Health)
Sherring, C. (Starship Children's Health)
Bushell, T. (Starship Children's Health)
Guan, Y. (KK Women's and Children's Hospital (Singapur))
Yao, L. (KK Women's and Children's Hospital (Singapur))
Lin, K. (National University Hospital (Singapur))
Ong, Jacqueline (National University Hospital (Singapur))
Salloo, A. (Chris Hani Baragwanath Hospital (Sud-àfrica))
Doedens, Linda G. (Chris Hani Baragwanath Hospital (Sud-àfrica))
Mathivha, Lufuno Rudo (Chris Hani Baragwanath Hospital (Sud-àfrica))
Reubenson, Gary (Rahima Moosa Mother and Child Hospital (Sud-àfrica))
Moaisi, S. (Rahima Moosa Mother and Child Hospital (Sud-àfrica))
Pentz, Adéle (Steve Biko Academic Hospital (Sud-àfrica))
Green, Robert S. (Steve Biko Academic Hospital (Sud-àfrica))
Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública

Data:	2015
Resum:	Introduction: Consensus criteria for pediatric severe sepsis have standardized enrollment for research studies. However, the extent to which critically ill children identified by consensus criteria reflect physician diagnosis of severe sepsis, which underlies external validity for pediatric sepsis research, is not known. We sought to determine the agreement between physician diagnosis and consensus criteria to identify pediatric patients with severe sepsis across a network of international pediatric intensive care units (PICUs). Methods: We conducted a point prevalence study involving 128 PICUs in 26 countries across 6 continents. Over the course of 5 study days, 6925 PICU patients <18 years of age were screened, and 706 with severe sepsis defined either by physician diagnosis or on the basis of 2005 International Pediatric Sepsis Consensus Conference consensus criteria were enrolled. The primary endpoint was agreement of pediatric severe sepsis between physician diagnosis and consensus criteria as measured using Cohen's κ. Secondary endpoints included characteristics and clinical outcomes for patients identified using physician diagnosis versus consensus criteria. Results: Of the 706 patients, 301 (42. 6 %) met both definitions. The inter-rater agreement (κ ± SE) between physician diagnosis and consensus criteria was 0. 57 ± 0. 02. Of the 438 patients with a physician's diagnosis of severe sepsis, only 69 % (301 of 438) would have been eligible to participate in a clinical trial of pediatric severe sepsis that enrolled patients based on consensus criteria. Patients with physician-diagnosed severe sepsis who did not meet consensus criteria were younger and had lower severity of illness and lower PICU mortality than those meeting consensus criteria or both definitions. After controlling for age, severity of illness, number of comorbid conditions, and treatment in developed versus resource-limited regions, patients identified with severe sepsis by physician diagnosis alone or by consensus criteria alone did not have PICU mortality significantly different from that of patients identified by both physician diagnosis and consensus criteria. Conclusions: Physician diagnosis of pediatric severe sepsis achieved only moderate agreement with consensus criteria, with physicians diagnosing severe sepsis more broadly. Consequently, the results of a research study based on consensus criteria may have limited generalizability to nearly one-third of PICU patients diagnosed with severe sepsis.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adolescent ; Biomedical Research ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Observer Variation ; Practice Patterns, Physicians' ; Prevalence ; Sepsis ; Treatment Outcome
Publicat a:	Critical care, Vol. 19 Núm. 1 (16 2015) , p. 325, ISSN 1466-609X

DOI: 10.1186/s13054-015-1055-x
PMID: 26373923

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