PEEP titration during prone positioning for acute respiratory distress syndrome

Web of Science: 22 cites, Scopus: 28 cites, Google Scholar: cites,

(Université de Lyon)
Ayzac, Louis (Hôpital Henri Gabrielle)
Mancebo, Jordi

(Institut d'Investigació Biomèdica Sant Pau)
Bates, Dina M. (University of California)
Malhotra, Atul (University of California)
Talmor, Daniel (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))
Universitat Autònoma de Barcelona

Data:	2015
Resum:	No major trial evaluating prone positioning for acute respiratory distress syndrome (ARDS) has incorporated a high-positive end-expiratory pressure (high-PEEP) strategy despite complementary physiological rationales. We evaluated generalizability of three recent proning trials to patients receiving a high-PEEP strategy. All trials employed a relatively low-PEEP strategy. After protocol ventilator settings were initiated and the patient was positioned per treatment assignment, post-intervention PEEP was not more than 5 cm HO in 16. 7 % and not more than 10 cm HO in 66. 0 % of patients. Post-intervention PEEP would have been nearly twice the set PEEP had a high-PEEP strategy been employed. Use of either proning or high-PEEP likely improves survival in moderate-severe ARDS; the role for both concomitantly remains unknown.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Humans ; Positive-Pressure Respiration ; Prone Position ; Respiratory Distress Syndrome, Adult
Publicat a:	Critical care, Vol. 19 Núm. 1 (december 2015) , p. 436, ISSN 1466-609X

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Registre creat el 2024-07-08, darrera modificació el 2025-11-06