The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
Urbano Ispizua, Álvaro (Hospital Clínic i Provincial de Barcelona)
Pavletic, Steven Z. (National Cancer Institute (Maryland, Estats Units))
Flowers, Mary E. (Fred Hutchinson Cancer Research Center)
Klein, John P. (Medical College of Wisconsin)
Zhang, Mei-Jie (Medical College of Wisconsin)
Carreras, Jeanette (Medical College of Wisconsin)
Montoto, Silvia (St. Bartholomew's Hospital)
Perales, Miguel-Angel (Memorial Sloan Kettering Cancer Center)
Aljurf, Mahmoud D. (King Faisal Specialist Hospital Center and Research)
Akpek, Görgün (Banner MD Anderson Cancer Center)
Bredeson, Christopher N. (Ottawa Hospital Research Institute)
Costa, Luciano J. (University of Alabama at Birmingham)
Dandoy, Christopher (Cincinnati Children's Hospital Medical Center)
Freytes, Cesar (University of Texas Health Science Center San Antonio)
Fung, Henry C. (Fox Chase Cancer Center (Philadelphia, Estats Units d'Amèrica))
Gale, Robert Peter (Imperial College London)
Gibson, John (Royal Prince Alfred Hospital)
Hamadani, Mehdi (Medical College of Wisconsin)
Hayashi, Robert J. (Washington University School of Medicine in St. Louis)
Inamoto, Yoshihiro (Fred Hutchinson Cancer Research Center)
Inwards, David (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Lazarus, Hillard M (University Hospitals Case Medical Center)
Maloney, David G. (Fred Hutchinson Cancer Research Center)
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau)
Munker, Reinhold (Louisiana State University Health (Louisiana, Estats Units d'Amèrica))
Nishihori, Taiga (H. Lee Moffitt Cancer Center and Research Institute)
Olsson, Richard F. (Uppsala University (Suècia))
Rizzieri, David A. (Duke University)
Reshef, Ran (University of Pennsylvania Medical Center)
Saad, Ayman (University of Alabama at Birmingham)
Savani, Bipin N. (Vanderbilt University Medical Center)
Schouten, Harry C. (Academische Ziekenhuis)
Smith, Sonali M. (University of Chicago)
Socié, Gérard (Hôpital Saint-Louis (París, França))
Wirk, Baldeep (Stony Brook University Medical Center)
Yu, Lolie C. (Children's Hospital/Louisiana State University Medical Center)
Saber, Wael (Medical College of Wisconsin)
Universitat Autònoma de Barcelona

Data:	2015
Resum:	The purpose of this study was to analyze the impact of graft-versus-host disease (GVHD) on the relapse rate of different lymphoma subtypes after allogeneic hematopoietic cell transplantation (allo-HCT). Adult patients with a diagnosis of Hodgkin lymphoma, diffuse large B cell lymphoma, follicular lymphoma (FL), peripheral T cell lymphoma, or mantle cell lymphoma (MCL) undergoing HLA-identical sibling or unrelated donor hematopoietic cell transplantation between 1997 and 2009 were included. Two thousand six hundred eleven cases were included. A reduced-intensity conditioning (RIC) regimen was used in 62. 8% of the transplantations. In a multivariate analysis of myeloablative cases (n = 970), neither acute (aGVHD) nor chronic GVHD (cGVHD) were significantly associated with a lower incidence of relapse/progression in any lymphoma subtype. In contrast, the analysis of RIC cases (n = 1641) showed that cGVHD was associated with a lower incidence of relapse/progression in FL (risk ratio [RR],. 51; P =. 049) and in MCL (RR,. 41; P =. 019). Patients with FL or MCL developing both aGVHD and cGVHD had the lowest risk of relapse (RR,. 14; P =. 007; and RR,. 15; P =. 0019, respectively). Of interest, the effect of GVHD on decreasing relapse was similar in patients with sensitive disease and chemoresistant disease. Unfortunately, both aGVHD and cGVHD had a deleterious effect on treatment-related mortality and overall survival (OS) in FL cases but did not affect treatment-related mortality, OS or PFS in MCL. This study reinforces the use of RIC allo-HCT as a platform for immunotherapy in FL and MCL patients.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Graft-versus-host disease ; Lymphoma
Publicat a:	Biology of blood and marrow transplantation, Vol. 21 Núm. 10 (january 2015) , p. 1746-1753, ISSN 1523-6536

DOI: 10.1016/j.bbmt.2015.05.010
PMID: 25981509

8 p, 929.0 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats