Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm : a CIBMTR analysis
Murthy, Hemant S. (Mayo Clinic Florida (Jacksonville, Estats Units d'Amèrica))
Zhang, Mei-Jie (Medical College of Wisconsin)
Chen, Karen (Medical College of Wisconsin)
Ahmed, Sairah (The University of Texas MD Anderson Cancer Center)
Deotare, Uday (London Health Sciences Centre)
Ganguly, Siddhartha (Houston Methodist Hospital)
Kansagra, Ankit (University of Texas Southwestern Medical Center)
Michelis, Fotios V. (Princess Margaret Cancer Centre (Toronto, Canadà))
Nishihori, Taiga (University of South Florida)
Patnaik, M. (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Abid, Muhammad Bilal (Medical College of Wisconsin)
Aljurf, Mahmoud (King Faisal Specialist Hospital and Research Centre (Aràbia Saudita))
Arai, Yasuyuki (Kyoto University)
Bacher, Ulrike (University of Bern)
Badar, Talha (Mayo Clinic Florida (Jacksonville, Estats Units d'Amèrica))
Badawy, Sherif M (Ann & Robert H. Lurie Children's Hospital of Chicago)
Ballen, Karen (University of Virginia Health System)
Battiwalla, Minoo (Sarah Cannon Blood Cancer Network)
Beitinjaneh, Amer (Sylvester Comprehensive Cancer Center)
Bejanyan, Nelli (Moffitt Cancer Center (Tampa, Estats Units d'Amèrica))
Bhatt, Vijaya Raj (University of Nebraska Medical Center)
Brown, Valerie I. (Penn State Hershey Children's Hospital)
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau)
Cahn, Jean-Yves (Université Grenoble Alpes)
Castillo, Paul (UF Health Shands Children's Hospital)
Cerny, Jan (University of Massachusetts Medical Center)
Chhabra, Saurabh (Medical College of Wisconsin)
Copelan, Edward (Atrium Health)
Daly, Andrew (Tom Baker Cancer Center)
Dholaria, Bhagirathbhai (Vanderbilt University Medical Center)
Díaz, Miguel A. (Hospital Infantil Universitario Niño Jesús (Madrid))
Freytes, Cesar (University of Texas Health Science Center at San Antonio)
Grunwald, Michael R. (Levine Cancer Institute)
Hashmi, Shahrukh K (Sheikh Shakhbout Medical City Abu Dhabi)
Hildebrandt, Gerhard (University of Missouri)
Jamy, Omer (University of Alabama at Birmingham)
Joseph, Jacinth (Methodist Healthcare Blood and Marrow Transplant Center)
Kanakry, Christopher G. (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Khera, Nandita (Mayo Clinic Arizona (Phoenix, Estats Units d'Amèrica))
Krem, Maxwell M. (Kansas City Veterans Affairs Medical Center)
Kuwatsuka, Yachiyo (Nagoya University Hospital)
Lazarus, Hillard M. (Case Western Reserve University)
Lekakis, Lazaros J. (Sylvester Comprehensive Cancer Center)
Liu, Hongtao (University of Chicago Medicine)
Modi, Dipenkumar (Wayne State University)
Munshi, Pashna N. (MedStar Georgetown University Hospital)
Mussetti, Alberto (Institut d'Investigació Biomèdica de Bellvitge)
Palmisiano, Neil (Thomas Jefferson University)
Patel, Sagar (The University of Utah)
Rizzieri, David A. (Novant Health Cancer Institute)
Seo, Sachiko (Dokkyo Medical University)
Shah, Mithun Vinod (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Sharma, Akshay (St. Jude Children's Research Hospital (Memphis, Estats Units d'Amèrica))
Sohl, Melhm (Northside Hospital)
Solomon, Scott R. (Northside Hospital Cancer Institute)
Ulrickson, Matthew (Banner MD Anderson Cancer Center)
Ustun, Celalettin (Rush University)
van der Poel, Marjolein (Maastricht University Medical Center)
Verdonck, Leo F. (Isala Clinic)
Wagner, John L. (Thomas Jefferson University)
Wang, Trent (Sylvester Comprehensive Cancer Center)
Wirk, Baldeep (Penn State Cancer Institute)
Zeidan, Amer (Yale University)
Litzow, Mark (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Kebriaei, Partow (The University of Texas MD Anderson Cancer Center)
Hourigan, Christopher (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Weisdorf, Daniel (University of Minnesota)
Saber, Wael (Medical College of Wisconsin)
Kharfan-Dabaja, Mohamed (Mayo Clinic Florida (Jacksonville, Estats Units d'Amèrica))
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with a poor prognosis and considered incurable with conventional chemotherapy. Small observational studies reported allogeneic hematopoietic cell transplantation (allo-HCT) offers durable remissions in patients with BPDCN. We report an analysis of patients with BPDCN who received an allo-HCT, using data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). We identified 164 patients with BPDCN from 78 centers who underwent allo-HCT between 2007 and 2018. The 5-year overall survival (OS), disease-free survival (DFS), relapse, and nonrelapse mortality (NRM) rates were 51. 2% (95% confidence interval [CI], 42. 5-59. 8), 44. 4% (95% CI, 36. 2-52. 8), 32. 2% (95% CI, 24. 7-40. 3), and 23. 3% (95% CI, 16. 9-30. 4), respectively. Disease relapse was the most common cause of death. On multivariate analyses, age of ≥60 years was predictive for inferior OS (hazard ratio [HR], 2. 16; 95% CI, 1. 35-3. 46; P =. 001), and higher NRM (HR, 2. 19; 95% CI, 1. 13-4. 22; P =. 02). Remission status at time of allo-HCT (CR2/primary induction failure/relapse vs CR1) was predictive of inferior OS (HR, 1. 87; 95% CI, 1. 14-3. 06; P =. 01) and DFS (HR, 1. 75; 95% CI, 1. 11-2. 76; P =. 02). Use of myeloablative conditioning with total body irradiation (MAC-TBI) was predictive of improved DFS and reduced relapse risk. Allo-HCT is effective in providing durable remissions and long-term survival in BPDCN. Younger age and allo-HCT in CR1 predicted for improved survival, whereas MAC-TBI predicted for less relapse and improved DFS. Novel strategies incorporating allo-HCT are needed to further improve outcomes.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Blood advances, Vol. 7 Núm. 22 (2023) , p. 7007-7016, ISSN 2473-9537

DOI: 10.1182/bloodadvances.2023011308
PMID: 37792849

10 p, 476.8 KB

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