Pharmacological modulation of vascular ageing : A review from VascAgeNet
Roth, L. (University of Antwerp)
Dogan, S. (Yeditepe University)
Tuna, B.G. (Yeditepe University)
Aranyi, T. (Semmelweis University)
Benitez, Sonia (Institut d'Investigació Biomèdica Sant Pau)
Borrell-Pages, Maria (Institut d'Investigació Biomèdica Sant Pau)
Bozaykut, P. (Acibadem Mehmet Ali Aydinlar University)
De Meyer, G.R.Y. (University of Antwerp)
Duca, L. (Université de Reims Champagne Ardenne (URCA))
Durmus, N. (Dokuz Eylul University)
Fonseca, D. (University of Coimbra)
Fraenkel, E. (Pavol Jozef Šafárik University of Košice)
Gillery, P. (Centre Hospitalier et Universitaire de Reims)
Giudici, A. (Maastricht University)
Jaisson, S. (Centre Hospitalier et Universitaire de Reims)
Johansson, M. (Lund University)
Julve i Gil, Josep (Institut d'Investigació Biomèdica Sant Pau)
Lucas-Herald, A.K. (University of Glasgow)
Martinet, W. (University of Antwerp)
Maurice, P. (Université de Reims Champagne Ardenne (URCA))
McDonnell, B.J. (Cardiff Metropolitan University)
Ozbek, E.N. (Ege University)
Pucci, G. (University of Perugia)
Pugh, C.J.A. (Cardiff Metropolitan University)
Rochfort, K.D. (Dublin City University)
Roks, A.J.M. (Erasmus University)
Rotllan, Noemi (Institut d'Investigació Biomèdica Sant Pau)
Shadiow, J. (University of Michigan)
Sohrabi, Y. (Charles University)
Spronck, B. (Macquarie University)
Szeri, F. (Institute of Enzymology)
Terentes-Printzios, D. (University of Athens)
Tunc Aydin, E. (Katip Celebi University)
Tura-Ceide, O. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Ucar, E. (Yeditepe University)
Yetik-Anacak, G. (Acıbadem Mehmet Aydinlar University)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. Pharmacological and dietary interventions targeting these pathways have shown potential in ameliorating age-related vascular changes. Nevertheless, the development and application of drugs targeting vascular ageing is complicated by various inherent challenges and limitations, such as certain preclinical methodological considerations, interactions with exercise training and sex/gender-related differences, which should be taken into account. Overall, pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population. Nonetheless, further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation.
Ajuts:	Ministerio de Economía y Competitividad CB15/00071 Ministerio de Economía y Competitividad CB16/11/00411
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	Arterial stiffness ; Dietary supplements ; Drugs ; Endothelial dysfunction ; Pharmacology ; Vascular ageing
Publicat a:	Ageing Research Reviews, Vol. 92 (december 2023) , p. 102122, ISSN 1872-9649

DOI: 10.1016/j.arr.2023.102122
PMID: 37956927

23 p, 4.5 MB

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