Risk of COVID-19 death for people with a pre-existing cancer diagnosis prior to COVID-19-vaccination : A systematic review and meta-analysis
Steinberg, Julia (University of Sydney)
Hughes, Suzanne (The University of Sydney)
Hui, Harriet (The University of Sydney)
Allsop, MatthewJ. (University of Leeds)
Egger, Sam (The University of Sydney)
David, Michael (Griffith University)
Caruana, Michael (The University of Sydney)
Coxeter, Peter (The University of Sydney)
Carle, Chelsea (The University of Sydney)
Onyeka, Tonia (IVAN Research Institute)
Rewais, Isabel (The University of Sydney)
Monroy Iglesias, Maria J. (King's College London)
Vives, Nuria (Hospital Universitari de Bellvitge)
Wei, Feixue (International Agency for Research on Cancer)
Abila, Derrick Bary (Makerere University College of Health Sciences)
Carreras, Giulia (Prevention and Research Institute (ISPRO))
Santero, Marilina (Institut d'Investigació Biomèdica Sant Pau)
O'Dowd, Emma L. (Nottingham University Hospitals NHS Trust (Regne Unit))
Lui, Gigi (The University of Sydney)
Tolani, Musliu Adetola (Ahmadu Bello University)
Mullooly, Maeve (RCSI University of Medicine and Health Sciences)
Lee, Shing Fung (Hospital Authority)
Landy, Rebecca (National Cancer Institute)
Hanley, Sharon J. B. (Hokkaido University)
Binefa, Gemma (Hospital Universitari de Bellvitge)
McShane, Charlene M. (Royal Victoria Hospital)
Gizaw, Muluken (Addis Ababa University)
Selvamuthu, Poongulali (Chennai Antiviral Research and Treatment Center and Clinical Research Site (CART CRS))
Boukheris, Houda (University Hospital of Bejaia)
Nakaganda, Annet (Uganda Cancer Institute)
Ergin, Isil (Ege University)
Moraes, Fabio Ynoe (Queen's University)
Timilshina, Nahari (University of Toronto)
Kumar, Ashutosh (All India Institute of Medical Sciences-Patna)
Vale, Diama B. (University of Campinas (UNICAMP))
Molina-Barceló, Ana (Fundación para la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (València))
Force, Lisa M. (University of Washington (Washington, Estats Units d'Amèrica))
Campbell, Denis Joan (The University of Sydney (Sydney, Austràlia))
Wang, Yuqing (University of Sydney (Sydney, Austràlia))
Wan, Fang (University of Sydney (Sydney, Austràlia))
Baker, Anna-Lisa (University of Sydney (Sydney, Austràlia))
Singh, Ramnik (University of Sydney (Sydney, Austràlia))
Salam, Rehana Abdus (The University of Sydney (Sydney, Austràlia))
Yuill, Susan (University of Sydney (Sydney, Austràlia))
Shah, Richa (Cancer Surveillance Branch (Lyon, França))
Lansdorp-Vogelaar, Iris (University Medical Center Rotterdam)
Yusuf, Aasim (Shaukat Khanum Memorial Cancer Hospital & Research Centre (Lahore, Pakistan))
Aggarwal, Ajay (Guy's & St Thomas NHS Trust (Londres, Regne Unit))
Murillo, Raúl H. (Pontificia Universidad Javeriana)
Torode, Julie S. (Guy's and St Thomas' NHS Foundation Trust (Regne Unit))
Kliewer, Erich V. (BC Cancer Research Institute)
Bray, Freddie (Cancer Surveillance Branch (Lyon, França))
Chan, Kelvin K. W. (Canadian Centre for Applied Research in Cancer Control)
Peacock, Stuart (Simon Fraser University (Burnaby, Canadà))
Hanna, Timothy (Queen's University (Kingston, Canadà))
Ginsburg, Ophira (National Cancer Institute (Rockville, Estats Units d'Amèrica))
Van Hemelrijck, Mieke (King's College London)
Sullivan, Richard (King's College London)
Roitberg, Felipe (Rede Brasileira de Serviços Hospitalares)
Ilbawi, André M. (Hospital Sírio Libanês)
Soerjomataram, Isabelle (Cancer Surveillance Branch (Lyon, França))
Canfell, Karen (The University of Sydney (Sydney, Austràlia))
Universitat Autònoma de Barcelona

Data:	2024
Resum:	While previous reviews found a positive association between pre-existing cancer diagnosis and COVID-19-related death, most early studies did not distinguish long-term cancer survivors from those recently diagnosed/treated, nor adjust for important confounders including age. We aimed to consolidate higher-quality evidence on risk of COVID-19-related death for people with recent/active cancer (compared to people without) in the pre-COVID-19-vaccination period. We searched the WHO COVID-19 Global Research Database (20 December 2021), and Medline and Embase (10 May 2023). We included studies adjusting for age and sex, and providing details of cancer status. Risk-of-bias assessment was based on the Newcastle-Ottawa Scale. Pooled adjusted odds or risk ratios (aORs, aRRs) or hazard ratios (aHRs) and 95% confidence intervals (95% CIs) were calculated using generic inverse-variance random-effects models. Random-effects meta-regressions were used to assess associations between effect estimates and time since cancer diagnosis/treatment. Of 23 773 unique title/abstract records, 39 studies were eligible for inclusion (2 low, 17 moderate, 20 high risk of bias). Risk of COVID-19-related death was higher for people with active or recently diagnosed/treated cancer (general population: aOR = 1. 48, 95% CI: 1. 36-1. 61, I = 0; people with COVID-19: aOR = 1. 58, 95% CI: 1. 41-1. 77, I = 0. 58; inpatients with COVID-19: aOR = 1. 66, 95% CI: 1. 34-2. 06, I = 0. 98). Risks were more elevated for lung (general population: aOR = 3. 4, 95% CI: 2. 4-4. 7) and hematological cancers (general population: aOR = 2. 13, 95% CI: 1. 68-2. 68, I = 0. 43), and for metastatic cancers. Meta-regression suggested risk of COVID-19-related death decreased with time since diagnosis/treatment, for example, for any/solid cancers, fitted aOR = 1. 55 (95% CI: 1. 37-1. 75) at 1 year and aOR = 0. 98 (95% CI: 0. 80-1. 20) at 5 years post-cancer diagnosis/treatment. In conclusion, before COVID-19-vaccination, risk of COVID-19-related death was higher for people with recent cancer, with risk depending on cancer type and time since diagnosis/treatment.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	COVID-19 ; Cancer ; Death ; Meta-analysis ; Systematic review
Publicat a:	International Journal of Cancer, Vol. 154 Núm. 8 (15 2024) , p. 1394-1412, ISSN 1097-0215

DOI: 10.1002/ijc.34798
PMID: 38083979

19 p, 3.7 MB

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