Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children
de Prado-Bert, Paula (Institut de Salut Global de Barcelona)
Warembourg, Charline (Institut de Salut Global de Barcelona)
Dedele, Audrius (Vytautas Magnus University. Department of Environmental Science)
Heude, Barbara (Université de Paris. Centre for Research in Epidemiology and Statistics)
Borràs, Eva (Universitat Pompeu Fabra)
Sabidó, Eduard (Universitat Pompeu Fabra)
Aasvang, Gunn Marit (Norwegian Institute of Public Health. Department of Environmental Health)
Lepeule, Johanna (Centre National de la Recherche scientifique. University Grenoble Alpes)
Wright, John (Bradford Teaching Hospitals NHS Foundation Trust. Bradford Institute for Health Research)
Urquiza, Jose (Institut de Salut Global de Barcelona)
Gützkow, Kristine B. (Norwegian Institute of Public Health. Department of Environmental Health)
Maitre, Léa (Universitat Pompeu Fabra)
Chatzi, Leda (University of Crete. Department of Social Medicine)
Casas, Maribel (Institut de Salut Global de Barcelona)
Vafeiadi, Marina (University of Crete. Department of Social Medicine)
Nieuwenhuijsen, Mark (Institut de Salut Global de Barcelona)
de Castro, Montserrat (Institut de Salut Global de Barcelona)
Grazuleviciene, Regina (Vytautas Magnus University. Department of Environmental Science)
McEachan, Rosemary R.C. (Bradford Teaching Hospitals NHS Foundation Trust. Bradford Institute for Health Research)
Basagaña, X. (Institut de Salut Global de Barcelona)
Vrijheid, Martine (Institut de Salut Global de Barcelona)
Sunyer, Jordi (Institut de Salut Global de Barcelona)
Bustamante, Mariona (Institut de Salut Global de Barcelona)

Data:	2022
Resum:	Exposure to air pollution influences children's health, however, the biological mechanisms underlying these effects are not completely elucidated. We investigated the association between short- and medium-term outdoor air pollution exposure with protein profiles and their link with blood pressure in 1170 HELIX children aged 6-11 years. Different air pollutants (NO2, PM10, PM2. 5, and PM2. 5abs) were estimated based on residential and school addresses at three different windows of exposure (1-day, 1-week, and 1-year before clinical and molecular assessment). Thirty-six proteins, including adipokines, cytokines, or apolipoproteins, were measured in children's plasma using Luminex. Systolic and diastolic blood pressure (SBP and DBP) were measured following a standardized protocol. We performed an association study for each air pollutant at each location and time window and each outcome, adjusting for potential confounders. After correcting for multiple-testing, hepatocyte growth factor (HGF) and interleukin 8 (IL8) levels were positively associated with 1-week home exposure to some of the pollutants (NO2, PM10, or PM2. 5). NO2 1-week home exposure was also related to higher SBP. The mediation study suggested that HGF could explain 19% of the short-term effect of NO2 on blood pressure, but other study designs are needed to prove the causal directionality between HGF and blood pressure.
Ajuts:	European Commission 308333 European Commission 874583 European Commission 733206 European Commission 211250 European Commission 226285 Ministerio de Economía y Competitividad CD12/00563 Instituto de Salud Carlos III MS16/00128 Generalitat de Catalunya SLT017/20/000119 Instituto de Salud Carlos III PT17/0019 Agencia Estatal de Investigación CEX2018-000806-S Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-595
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Air pollution ; Blood pressure ; Childhood ; Environment ; Plasmatic proteins ; Short-term effects
Publicat a:	Environmental research, Vol. 211 (August 2022) , art. 113109, ISSN 1096-0953

DOI: 10.1016/j.envres.2022.113109
PMID: 35292243

10 p, 583.8 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats