Increased risk of arrhythmias, heart failure, and thrombosis in SARS-CoV-2 positive individuals persists at one year post-infection
Tintore, C. (Universitat de Vic, Universitat Central de Catalunya (UVic-UCC))
Cuartero Archs, Jordi (Institut de Recerca Sant Pau)
Camps-Vilaró, Anna (Institut Hospital del Mar d'Investigacions Mèdiques)
Subirana, None (Institut Hospital del Mar d'Investigacions Mèdiques)
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques)
Marrugat, J. (Institut Hospital del Mar d'Investigacions Mèdiques)
Degano, I.R. (Institut de Recerca i Innovació en Ciències de la Vida i de la Salut a la Catalunya Central)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Risk of cardiovascular events is increased after COVID-19. However, information on cardiovascular risk trends after COVID-19 infection is lacking and estimates by sex are inconsistent. Our aim was to examine cardiovascular outcomes and mortality in a large cohort (164,346 participants) of SARS-CoV-2 positive individuals compared to non-positive individuals, stratified by sex. Data were obtained from the Spanish Health System's electronic medical records. Selected individuals were ≥ 45 years old with/without a positive SARS-CoV-2 test in the period March-May 2020. Follow-up was obtained until January 31, 2021, for cardiovascular events (angina/myocardial infarction, arrhythmias, bypass/revascularization, heart failure, peripheral artery disease, stroke/transient ischemic attack, and thrombosis), and until March 31, 2021, for mortality. Individuals were matched by propensity score. Incidence of cardiovascular events and mortality was compared with accelerated failure time models. The effect of matching and of COVID-19 severity was assessed with sensitivity analyses. In the first 3 months of follow-up, SARS-CoV-2 positive individuals had a higher risk of mortality and of all cardiovascular events. From 4-12 months, there was increased risk of mortality in SARS-CoV-2 positive individuals overall, of heart failure in SARS-CoV-2 positive females (HR= 1. 26 [1. 11-1. 42]), and of arrhythmias and thrombosis in SARS-CoV-2 positive males (HR= 1. 29 [1. 14-1. 47] and HR= 1. 35 [1. 03-1. 77], respectively). When COVID-19 patients admitted to the ICU were excluded, incidence of thrombosis was similar in males regardless of positive/non-positive SARS-CoV-2 status. In the full year of follow-up, increased incidence of heart failure and of arrhythmias and thrombosis was observed in SARS-CoV-2 positive females and males, respectively.
Ajuts:	Instituto de Salud Carlos III PI21/00163 Instituto de Salud Carlos III CB/16/11/00229
Nota:	Altres ajuts: Agència de Qualitat i Avaluació Sanitàries de Catalunya, P635/COVID19
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	COVID-19 ; Cardiovascular disease ; Mortality ; SARS-CoV-2
Publicat a:	Computational and Structural Biotechnology Journal, Vol. 24 (december 2024) , p. 476-483, ISSN 2001-0370

DOI: 10.1016/j.csbj.2024.06.024
PMID: 39050244

8 p, 4.9 MB

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